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Biomedical subjects

J Jerábek

Publications and source records attributed to J Jerábek.

At least 19 recordsLinked to original sources
PubMed2005

[Retromuscular mesh repair of a hernia in a scar according to Rives--our first experience].

The authors present a group of 24 patients with hernias in scars operated from February 2004 to January 2005 (12 months) using a retromuscular reconstruction procedure according to Rives. 20 procedure following central laparotomies and 4 procedures following lateral laparotomies were conducted. The defect sizes ranged from 5 to 16 cm. A polypropylene mesh was used which was placed between the rectus abdominis muscle and the posterior leaf of the rectus abdominis sheath. The mesh was covered by the fascia with a minimum overlap of 5 cm in all directions. The mean follow- up period was six months (1-12 months) and no early relapses were recorderd. The complications rate was acceptable--1x secondary wound healing, 2x seroma, 1x non-transmural MI in a patient with a cardiac ischemic disorder. The retromuscular reconstruction procedure according to Rives appears to be an appropriate method for management of large ventral hernias with excellent results and minimum complications.

Abdominal Muscles↗
PubMed2004

Paraneoplastic opsoclonus-myoclonus syndrome associated with malignant fibrous histiocytoma: neuropathological findings.

Paraneoplastic syndromes related to soft tissue tumors are very uncommon and an association of paraneoplastic diseases with a malignant fibrous histiocytoma (MFH) has not been reported so far. Opsoclonus-myoclonus is a rare paraneoplastic nervous system syndrome, that was well documented in adult patients with neoplasms particularly of the lung and breast. A 77-year-old woman developed typical opsoclonus-myoclonus syndrome and rapidly progressed to coma. The opsoclonus and generalized myoclonus continued until the patient's death seven months later. An autopsy examination identified a pleomorphic MFH in the retroperitoneum without a metastatic spread. Microscopic examination of the cerebellum revealed an atrophy of the granular layer along with a marked patchy loss of Purkinje cells, and a loss of neurons in the cerebellar nuclei accompanied by distinct peridental demyelination and astrogliosis. A moderate loss of neurons and neuronal chromatolysis were observed also in the inferior olivary nuclei. However, the omnipause neurons of the nucleus raphe interpositus, that are supposed to be responsible for opsoclonus generation under pathological conditions, as well as ocular brain stem nuclei were all intact. We failed to prove the presence of known antineuronal anti-Yo, anti-Hu or anti-Ri autoantibodies in both serum and cerebrospinal fluid (CSF) of the patient. However, the confirmation of the intrathecal IgG synthesis by oligoclonal bands in CSF and the immunohistochemical detection of IgG deposits on membranes of Purkinje cells, neurons of cerebellar granular layer and in cerebellar nuclei in our case support the presumed autoimmune nature of the disease.

Aged↗
PubMed1996

Developmental effects of magnetic field (50 Hz) in combination with ionizing radiation and chemical teratogens.

The influence of a 50 Hz magnetic field (MF) on avian and mammalian embryogenesis, the MF level and vector, as well as the effect of exposure to MF (50 Hz, 10 mT) in combination with X-rays has been recently reported [2,3]. No significant alterations of chick or rat embryogenesis were found after repeated exposures to 50 Hz MF at 10 mT or 6 microT or with different vectors. However, X-ray chick embryotoxicity was significantly affected by repeated exposures of developing organisms to MF. A strong dependence of effect on the type of interaction was revealed. A decrease of X-ray induced teratogenicity was observed when MF preceded X-ray exposure (indirect interaction), while MF exposure applied immediately after X-ray radiation (direct interaction) non-significantly potentiated adverse developmental effects of ionizing radiation. This study deals with the effects of MF in combination with insulin or tetracycline. Exposure of chick embryos to MF influenced the sensitivity of embryonic morphogenetic systems to the subsequently administered chemical teratogens, insulin and/or tetracycline. A protective effect of MF was detected similarly as in the case of indirect interaction with ionizing radiation.

Abnormalities, Drug-Induced↗
PubMed1990

[Agreement between auditory threshold calculated from cortical evoked response audiometry and tone audiometry in occupational hearing loss].

In a group of 126 men the authors evaluated the auditory threshold from cortical ERA findings and comparison with their threshold sound audiometry. The mean age of the patients means = 52.5 years (min. = 25 years, max. = 69 years, s = 8.95). Noise exposure means = 16.5 years (min. = 4 years, max. = 30 years, s = 4.5). In 79.3% the men worked as miners in uranium mines, other mining occupations were represented only by small numbers. The arithmetic mean of the total percentage hearing loss (calculated according to Fowler) means = 49.7% (min. = 17%, max. = 100%, s = 15). The cumulative frequency of differences between the auditory threshold of the sound audiogram and cortical ERA: (table; see text) The cumulative frequency of differences in the total percentage hearing loss between sound audiograms and cortical ERA: differences up to +/- 5% hearing loss were recorded in 24.3% of the group, differences up to +/- 10% in 43.9%, differences up to +/- 15% in 58.9%, differences up to +/- 20% in 70.1%. In the group of 126 examined subjects we detected 12 aggravating subjects (9.5%), their mean age being by 6.7 years lower than the mean of the whole group, the mean exposure to noise is by 3.2 years shorter. The differences between the auditory threshold reported by the aggravating men and the cortical ERA are highest in verbal frequencies, on average they are per fr of 2 kHz 27.3 dB, 1 kHz 24.3 dB, 0.5 kHz 20.1 dB, 4 kHz, 10.0 dB. The differences between the total percentage auditory loss calculated from sound audiograms and cortical ERA reaches on average 41.5%.

Aged↗
PubMed1990

[The effect of muscle relaxants on the function of the vestibulo-ocular reflex arc].

Baclofen affects in experiments the reactivity of the vestibuloocular reflex by influencing the time constant of the vestibular nystagmus. The authors compare in three healthy volunteers the reactivity of the vestibular apparatus after administration of Baclofen and a new muscle-relaxant drug tizanidine. The authors evaluate basic parameters of the vestibular and optokinetic nystagmus (gain and time constant), discuss the problem of GABAergic (Baclofen) and monoaminergic (tizanide) receptors kin the area of the vestibular apparatus. As regards the effect on the reactivity of the vestibular system, tizanidine does not affect immediately the response of the vestibuloocular reflex but interferes with processes ensured by the central neuronal integrator.

Adult↗
PubMed1989

Specific antibody against the Aujeszky's disease virus in the complex cumulus oophorus-oocyte of sows.

Oocytes collected from sows vaccinated and revaccinated with an inactivated vaccine against Aujeszky's disease (AD) were examined for the presence of specific antibodies of the IgG class against AD virus in the complex cumulus oophorus-oocyte by means of immunocytochemical methods. No specific antibody of the IgG class was detected in the cumulus-oocyte complexes collected from sows before vaccination. On the other hand, the specific IgG antibody was found in all immunocytochemically examined complexes cumulus-oocyte collected from revaccinated sows. The specific antibody of the IgG class against AD virus and the porcine IgG were immunocytochemically visualized under both light and electron microscopes as a fine granular product disseminated in oocytes and follicular cells.

Animals↗
PubMed1989

[The relation between the auditory threshold and the threshold of middle ear reflexes induced by ipsilateral stimulation in occupational deafness].

The author examined and evaluated middle ear reflexes obtained by ipsilateral stimulation in a group of 115 men, mean age 52.5 years (s = 9 years) who worked exposed to noise in uranium mines on average for 16.5 years (s = 4.6 years). Their total percentage auditory loss calculated according to Fowler is 49.7% (s = 15.1%). The arithmetic mean of differences of the auditory threshold and the threshold of middle ear reflexes in 214 ears examined at a frequency of 1000 Hz is 45.5 dB (s = 16.3 dB, min. 0 dB, max. 80 dB), in 208 ears at a frequency of 2000 Hz 30.4 dB (s = 13.5 dB, min. 0 dB, max. 75 dB), in 196 ears at frequency 3000 Hz 23.2 dB (s = 12.6 dB, min. 0 dB, max. 85 dB). The relation--ship between the auditory threshold and middle ear reflexes obtained by ipsilateral stimulation corresponds to the following equations Y1000Hz = 105.86--9.73 square root chi i Y2000Hz = 119.21--11.61 square root chi i Y3000Hz = 108.62--10.59 square root chi i Individual forecasts of the auditory threshold for pure tones only from values of the threshold of middle ear reflexes in occupational deafness are of restricted value due to the great scatter of values.

Auditory Threshold↗
PubMed1989

Positive effect of direct current on cytotoxicity of human lymphocytes.

Normal or leukemic human lymphocytes treated with direct current (DC) showed enhanced antileukemic cytotoxicity. The enhancing effect of DC-treated lymphocytes was dependent on current density and time exposure. A desirable effect was achieved with current densities ranging from 5 to 10 mA/cm2 at a short exposition time (5--10s). Enhanced lymphocyte cytotoxicity occurred after a 48 h cultivation at 37 degrees C in a humidified atmosphere containing 5% CO2 and was proved by the increased number of trypan blue stained target cells, tumor-binding cells, and lymphocytes with activated nucleoli. Lymphocyte cytotoxicity measured immediately after DC-treatment was not enhanced. Furthermore, the cytotoxic effect was potentiated using media conditioned with interleukin-2 (IL-2) or cytosol fraction (F3) isolated from human leukemic cells. Such in vitro stimulated cytotoxic cells displayed reactivity against K 562 cells as well as fresh leukemic cells of allogeneic origin. Of considerable clinical interest is the observation that lymphocytes treated with DC in IL-2 or F3 conditioned media may enhance antileukemic cytotoxicity in peripheral lymphocytes of patients with hematological malignancies.

Cytosol↗