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Biomedical subjects

J Jentzen

Publications and source records attributed to J Jentzen.

6 recordsLinked to original sources
PubMed1994

Death after discharge from the emergency department.

STUDY OBJECTIVE: To determine the rate and cause of death of patients who were evaluated in the emergency department and discharged and how the cause of death related to the ED visit. DESIGN: Retrospective chart review of medical examiner cases from July 1, 1990, to June 30, 1991. SETTING: Urban county served by 13 hospital EDs with 383,416 visits in 1991. Eighty-five percent of these patients were discharged. PARTICIPANTS: Medical examiner cases of patients who had been evaluated and released from an ED within 8 days prior to death. RESULTS: Forty-two of the 2,665 medical examiner cases met inclusion criteria. Death was classified as expected or unexpected based on the patient's clinical status at the time of discharge, and directly related or not directly related to the ED visit, based on review of all records and the cause of death as listed on the death certificate. Six deaths (14%) were considered expected and directly related. Three deaths (7%) were considered expected and not directly related. Twenty-four deaths (57%) were considered unexpected and not directly related. Nine deaths (21%) were considered unexpected and directly related; the most common cause was ruptured aortic aneurysm, occurring in three of these nine cases. The death rate was 13 per 100,000 discharged patients. CONCLUSION: Death after discharge from the ED is uncommon. The most common cause of unexpected, directly related death is ruptured aortic aneurysm.

Adolescent↗
PubMed1994

Destructive hostility: the Jeffrey Dahmer case. A psychiatric and forensic study of a serial killer.

We were involved as forensic experts in the case of the serial killer Jeffrey Dahmer. We discuss the scene and victim autopsy findings, with a brief consideration of the basic emotion of hostility. These findings support the thesis that at the basis of this serial killer's behavior were primary unconscious feelings of hate that he had channeled into a sadistic programmed destruction of 17 young men. The interview of the serial killer, the photographic scene documentation, and the autopsy findings stress the ambivalent homosexuality of the killer, his sexual sadism, his obsessive fetishism, and his possible cannibalism and necrophilia.

Adolescent↗
PubMed1987

Myocardial necrosis due to intraperitoneal administration of phenylpropanolamine in rats.

Overdose with the sympathomimetic agent phenylpropanolamine (PPA) may cause arrhythmias and myocardial injury in humans. To study the mechanism of these toxic effects, unanesthetized rats (6 animals per group) were given single intraperitoneal doses of 1, 2, 4, 8, 16, or 32 mg/kg PPA. Increases in blood pressure, measured by tail cuff, were dose related and comparable to increases reported in patients with PPA toxicity. Animals were killed at 24 hr and light microscopic examination showed diffuse, dose-related myocardial necrosis. Histology scores (a measure of severity of necrosis) in groups receiving 8, 16, and 32 mg/kg PPA were 1.4 +/- 0.5, 1.8 +/- 1.0, and 2.3 +/- 0.4, respectively, and were all significantly greater than the histology score of control animals (0.2 +/- 0.3, p less than 0.01). The observed lesion was similar in appearance to the myocardial necrosis produced by large doses of catecholamines or sympathomimetic agents in rats. In summary, single doses of PPA caused myocardial necrosis in rats at doses comparable to those causing toxicity in humans. Myocardial necrosis may contribute to the cardiac toxicity of PPA overdose.

Animals↗
PubMed1985

Fatal acute selenium toxicity.

Selenium is used widely in industry and as a dietary supplement. Reports of acute selenium toxicity are infrequent, however, and the relationship of toxicity to selenium concentrations in blood and tissues has not been established. We describe a patient who died eight days after ingesting selenious acid in the form of gun blueing. The patient's clinical course demonstrated many of the features of inorganic selenium toxicity described in animals; hypotension as a result of both vasodilation and decreased cardiac output, adult respiratory distress syndrome, severe myopathy which contributed to respiratory failure, and a garlicky odor to the breath. Four days after ingestion the serum selenium concentration was twenty times normal and urinary excretion seventy times normal. Postmortem tissue selenium concentrations were up to 40 times normal.

Female↗
PubMed1984

Pulmonary oxygen toxic effect. Occurrence in a newborn infant despite low PaO2 due to an intracranial arteriovenous malformation.

A newborn infant with a massive left to right shunt secondary to a cerebral arteriovenous malformation required continuous oxygen therapy in high concentrations. Despite high PO2, the infant maintained low to normal PaO2 concentrations. Light and ultrastructural studies of the lungs demonstrated typical changes of acute pulmonary oxygen toxicity, including degeneration of capillary endothelium and type I pneumonocytes, interstitial edema, and alveolar exudation. These observations confirm earlier experimental animal studies that demonstrated that the alveolar Po2 concentration and not the Pao2 is the major factor contributing to pulmonary oxygen toxic effect.

Humans↗