Search PubMed⌕ Search

Biomedical subjects

J Jensen

Publications and source records attributed to J Jensen.

At least 469 records · Page 26Linked to original sources
PubMed1986

Arthroscopy in acute knee injuries.

The diagnostic value of arthroscopy was evaluated in 148 patients with acute hemarthrosis and/or instability of the knee. The treatment planned after clinical examination was compared with the treatment given after arthroscopy. Seventy-nine per cent of the patients had ligamentous injuries; 59 per cent of tears were combined with other injuries, and 71 per cent were complete ruptures. Stability testing under anesthesia was most inaccurate for the anterior cruciate ligament, with 13 per cent false positive and 30 per cent false negative results. The planned treatment was altered as a consequence of arthroscopy in 31 per cent of cases. Without arthroscopy, the preoperative diagnoses would have been seriously wrong in 15 per cent of the patients. Twenty per cent of total anterior cruciate ligament ruptures would have been overlooked.

Adolescent↗
PubMed1986

Untoward effects of fenfluramine in autistic children.

Several recent studies have described the benefits of fenfluramine for the symptomatic treatment of infantile autism. No large surveys of side effects of this drug have been reported in autistic children. To evaluate the untoward effects of fenfluramine in children with autism, 12 subjects were systematically studied. Medication was administered in a double-blind, placebo-controlled cross-over study. Parents were trained in monitoring untoward effects. These observations were compiled in detailed daily notes. In addition, four cases describing unusual effects found in a sample of 170 patients treated with fenfluramine are also reported. In the initial 2 weeks of active drug listlessness, food refusal, and stomach upset were frequently seen. A different pattern of untoward effects was seen in the final 14 weeks of treatment. Irritability, agitation, and crying along with continued food refusal were noted. The subjects lost 2.1% of body weight during active drug phase, but there was a rebound weight gain during the subsequent placebo phase. A thorough understanding of fenfluramine's side effects and adverse reactions is necessary so as to differentiate them from the multiple symptoms inherent in the syndrome of autism.

Adolescent↗
PubMed1985

Cigarette smoking, serum estrogens, and bone loss during hormone-replacement therapy early after menopause.

To elucidate the effect of smoking on estrogen metabolism, we examined 136 postmenopausal women treated for one year with one of three different doses of combined estrogen-progestogen or placebo. The women were grouped according to smoking status, and serum levels of estrone and estradiol were measured before and after treatment. The results showed reduced levels of both estrogens in smokers as compared with nonsmokers in all three dosage groups. This reduction was most pronounced in the high-dose group (4 mg of estradiol), in which the serum levels of estrone and estradiol in smokers were only 50 per cent of those in nonsmokers (P less than 0.001 and less than 0.05, respectively). In contrast, no significant changes could be demonstrated in the corresponding placebo groups. Moreover, it was possible to demonstrate significant inverse correlations between the number of cigarettes smoked daily and the changes in the levels of serum estrone and estradiol, respectively, (P less than 0.001). This study suggests that an increased hepatic metabolism of estrogens results in lower estrogen levels among postmenopausal smokers. This may contribute to the reported risk of osteoporosis among smokers.

Adult↗