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Biomedical subjects

J Jensen

Publications and source records attributed to J Jensen.

At least 325 records · Page 18Linked to original sources
PubMed1990

Bovine natural cell mediated cytotoxicity (NCMC): activation by cytokines.

Incubation of bovine peripheral blood mononuclear leukocytes (PBML) with the cytokines (CK) IL-2, alpha-IFN, gamma-IFN or IL-4 resulted in significant increases in natural cell mediated cytotoxicity (NCMC) over endogenous levels, as determined in an 18 h 51Cr-release assay using the human K562 or mouse Yac-1 target cell lines. Endogenous cytotoxic activity of bovine natural effector cells (NEC) using K562 or Yac-1 target cells was minimal (killing less than 8%). After 18 h of incubation with the CK hurIL-2, alpha-bovrIFN, gamma-bovrIFN or hurIL-4, NEC had significant increases in cytotoxic activity for both K562 and Yac-1 target cells. Significant increases in cytotoxic activity were not found after incubation of NEC with IL-1 or beta-IFN. Specific killing varied with CK concentration in a dose dependent manner and was proportional to effector:target cell ratio. Activation of the bovine NEC by CK was rapid, occurring within 6-12 h of incubation with alpha-IFN or gamma-IFN and within 12-18 h of incubation with IL-2. Incubation of bovine PBML with IL-2 and alpha- or gamma-IFN or with alpha-IFN and gamma-IFN showed that these CK do not act in a synergistic manner to increase NCMC in the bovine NEC.

Animals↗
PubMed1990

Reconstruction of the severely resorbed maxilla with bone grafting and osseointegrated implants: a preliminary report.

This article describes a surgical procedure for rehabilitation of the severely atrophic maxillary alveolar ridge by bone grafting to the maxillary sinus and nasal floor followed by installation of implants in the grafted regions at a second operation. Five treated cases are presented. Further data are considered necessary to evaluate the procedure before it can be recommended for routine use.

Adult↗
PubMed1990

Influence of menopause on serum lipids and lipoproteins.

The influence of the menopause on serum lipids and lipoproteins was examined longitudinally at 6-week intervals for 2-3 years in pre-menopausal women undergoing the menopause. Serum lipid and lipoprotein profiles were also examined cross-sectionally in 4 groups of pre-menopausal, peri-menopausal and post-menopausal women, who were followed up longitudinally at 3-monthly examinations for 1-2 years. The results covering 1360 examinations and 270 woman-years are reported here. Serum concentrations of total cholesterol (P = 0.001), low-density-lipoprotein (LDL) cholesterol (P = 0.001) and triglycerides (P less than 0.05) increased significantly as a consequence of the menopause and all increases occurred within 6 months of cessation of menstrual periods. High-density-lipoprotein (HDL) cholesterol decreased significantly (P less than 0.05) as a consequence of the menopause, but the decline occurred gradually over the 2 years preceding cessation of menses. In addition to the menopausal changes, serum concentrations of total cholesterol and LDL-cholesterol increased gradually in the pre-menopausal and post-menopausal years, but were significantly related to biological age only in the pre-menopausal groups (P less than 0.05). Serum triglycerides and HDL-cholesterol levels remained virtually unchanged in the pre-menopausal as well as the post-menopausal groups and were only influenced by the actual menopause. Serum lipids and lipoproteins are thus significantly altered as a consequence of the menopause. The result is a more atherogenic lipid profile which may partly explain the increased risk of cardiovascular disease observed in post-menopausal women.

Adult↗
PubMed1990

Smoking induces increased androgen levels in early post-menopausal women.

In order to clarify the effect of smoking on androgen status in the early post-menopause we examined 267 women aged 45-54 years, of whom 146 (55%) were smokers. The cigarette smokers had a significantly higher serum concentration of androstenedione (P less than 0.001) and a raised serum concentration of luteinizing hormone (P = 0.06) in comparison with the non-smokers. The number of cigarettes consumed was apparently immaterial. The concentrations of oestrone, oestradiol and follicle-stimulating hormone were similar in the two groups. This study lends support to the hypothesis that the observed decreased risk of endometrial and breast cancer associated with cigarette smoking may be mediated by androgenic protection.

Androstenedione↗
PubMed1990

Intermaxillary fixation of mandibular fractures with the bracket-bar.

An alternative method for intermaxillary fixation of mandibular fractures using a bracket-bar bonded to the teeth is described. The technique is easy to use, improves gingival health, reduces anaesthesia time and reduces the risk of transmitting blood-borne diseases to the surgeon through perforating injuries from wires.

Dental Bonding↗
PubMed1990

Depressive symptom patterns among older women.

The structure of depressive symptom patterns was investigated in a community sample of 344 women between the ages of 51 and 92 who were administered the SCL-90-R Depression and Additional Symptoms Scales. Confirmatory factor analysis was used to test alternative measurement hypotheses implied by clinical formulations of depressive symptom patterns among elderly persons. The findings show support for the hypothesis that 2 somewhat different depressive syndromes, along with 4 more delimited forms of distress, underlie symptom-reporting patterns. Implications of these findings for future research on the relation between aging and depression are discussed.

Aged↗
PubMed1990

Epirubicin or epirubicin and vindesine in advanced breast cancer. A phase III study.

One hundred thirty-three evaluable patients with advanced breast cancer entered a randomized trial comparing epirubicin 60 mg/m2 with a combination of epirubicin 45 mg/m2 and vindesine 3 mg/m2 day 1 and 8 every 4 weeks. In all 10 premenopausal women an oophorectomy was performed. Seventy-five patients had previously received cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) for advanced disease and 68 had received adjuvant chemotherapy (cyclophosphamide or CMF). Among evaluable patients (72 in the epirubicin group and 61 in the epirubicin + vindesine group) response rates were as follows: complete response--seven versus six; partial response--31 versus 22; no change--16 versus 17 (p greater than 0.40). Median time to disease progression was 6 months in both groups and median survival times were identical (12 months). Thrombocytopenia was less frequent in the epirubicin + vindesine group (p less than 0.01). In the epirubicin + vindesine group, mild to moderate peripheral neuropathy was observed in 40% of the patients. Congestive heart failure developed in one patient with a cumulative dose of epirubicin less than 1000 mg/m2 and in 7 of 15 patients who had greater than 1000 mg/m2. Four died of this cause. In conclusion, epirubicin is effective as a single agent for advanced breast cancer. The combination with vindesine does not increase its efficacy.

Adult↗
PubMed1990

Cytomegalovirus-induced osteomyelitis in a patient with the acquired immunodeficiency syndrome.

A 43-year-old man with AIDS had a periodontal abscess, no fever, and normal findings on funduscopic examination. Three months later, the abscess area was debrided, and histologic examination of the tissue revealed osteomyelitis of the mandible. Within the area of osteomyelitis were numerous cells with inclusions typical of cytomegalovirus (CMV) infected cells. Funduscopic examination at that time revealed extensive CMV retinitis. Osteomyelitis should be added to the list of infections caused by CMV in patients with AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1990

The effect of the benzodiazepine antagonist flumazenil on regional cerebral blood flow in human volunteers.

The influence of the benzodiazepine antagonist flumazenil on regional cerebral blood flow (rCBF) was investigated in ten healthy, alert volunteers. The design was a randomized, placebo-controlled, double-blind, cross-over study. rCBF was measured by 133-Xe inhalation and single photon emission computerized tomography, SPECT, immediately before, and 5 and 35 min after intravenous injection of flumazenil 1.0 mg or placebo. In addition, mean arterial blood pressures or PaCO2, rCBF were analysed for changes in various regions of interest (RoI). No alterations were found either in the global CBF or in rCBF in RoI after flumazenil injection. The results showed that a clinically active dose of flumazenil did not directly affect the cerebral circulation in the normal brain and indicated absence of significant intrinsic activity of the drug.

Adult↗
PubMed1990

Comparison between Bactec Nr. 660 and a conventional 12-tube blood culture system.

The detection power of the automated blood culture system Bactec NR 660, based on infrared detection of carbon dioxide in an agitated aerobic medium and a non-agitated anaerobic medium, was compared with that of our conventional 12-tube blood culture system. Of 1685 paired blood cultures, 258 (15.3%) were positive in one or both systems. Clinically relevant isolates were found in 11.5%. The dominating species were Escherichia coli(41%), followed by Staphylococcus aureus(14%) and Klebsiella spp.(8%). The Bactec system detected 178 (10.6%) and the 12-tube system 157 (9.3%) clinically relevant microorganisms after seven days' incubation. Significantly more clinically relevant isolates were detected by the Bactec system alone as compared with the conventional system alone (40 versus 19, p less than 0.01). The detection time was significantly shorter in the Bactec system for all isolates and for E. coli and S. aureus separately (p less than 0.01). 1.8% of the isolates in the Bactec system and 2.1% in the 12-tube system were considered clinically non-relevant contaminants.

Autoanalysis↗
PubMed1990

Badminton injuries.

In a one year period, from 1 January 1986 to 31 December 1986, 4303 patients with sports injuries were treated at Aarhus Amtssygehus and Aarhus Kommunehospital. The mean age was 21.6 years (range 7-72 years) and 2830 were men. Two hundred and seventeen badminton injuries occurred in 208 patients (136 men) with a mean age of 29.6 years (range 7-57 years), constituting 4.1 percent of all sport injuries in Aarhus. Joints and ligaments were injured in 58.5 percent of the patients, most frequently located in the lower limb and significantly more often among patients younger than 30 years of age. Muscle injury occurred in 19.8 percent of the patients. This type of injury was significantly more frequent among patients older than 30 years of age. Most injuries were minor. However, 6.8 percent of the patients were hospitalized and 30.9 percent received additional treatment by a physician. As the risk of injury varies with age, attempts to plan training individually and to institute prophylactic measures should be made.

Adolescent↗
PubMed1990

A dimensional approach to severe delusional psychoses.

By use of latent trait models a 7-item rating scale of severe delusional psychoses was established based on the PSE interview. Data from 88 first-admitted patients with delusional psychoses were analysed. These data assigned good internal validity of the scale and revealed a dimensional rather than a categorical distribution of severe delusional psychoses. Using schizophrenia as a reference, the scale with a cut-off point greater than or equal to 1 established the diagnosis with a sensitivity of 0.84 and a specificity of 0.95. In a study to come a latent class analysis among deluded patients will be performed.

Delusions↗
PubMed1990

Latent class analysis of deluded patients.

The internal and external construct validity of 4 severe prognostic psychopathological items is studied in deluded patients. A two-class model of latent structure analysis fits fairly well. One latent class seems to reflect a schizophrenic spectrum while the other class does not include characteristics which are known from one single nosologic entity. Thought disorder is most predictive for schizophrenic class membership, while blunted affect has the least predictive value. This 'schizophrenic' latent class has a fairly high and similar sensitivity to various definitions of schizophrenic disorder. The frequency of the types of delusions differs between the classes.

Affective Symptoms↗
PubMed1990

Stochastic modeling of multiple ovulation and embryo transfer breeding schemes in small closed dairy cattle populations.

Genetic changes and genetic drift in three small closed dairy cattle populations were examined with a stochastic simulation model. Multiple ovulation and embryo transfer and AI techniques were simulated in three populations, two with 88 breeding females each and one with 352 breeding females. The selection goal was to maximize genetic improvement in milk yield. The reduction in genetic variation due to inbreeding and linkage disequilibrium was accounted for in the simulation. Strict restriction against inbred mating slowed genetic progress significantly in the small population but would not be consequential in the larger population. However, allowing inbred mating in the smaller population caused a rapid accumulation of inbreeding. Linkage disequilibrium was as important as inbreeding in reducing genetic variation. Genetic drift variance was much smaller in the larger population.

Animals↗
PubMed1990

Heterotopic bone formation after total hip arthroplasty in patients with primary or secondary coxarthrosis.

Heterotopic bone formation was investigated in 392 Charnley low-friction total hip arthroplasties. A multivariate linear regression analysis was used to account for the influence of co-variables: sex, age at surgery, postoperative treatment with antiinflammatory drugs during at least the first 2 weeks, and previous ipsilateral hip surgery. A total of 232 hips had been treated for primary coxarthrosis, and 114 and 46 hips for secondary coxarthrosis due to congenital dislocation and fracture-dislocation of the hip, respectively. None of the hips with primary coxarthrosis previously had ipsilateral hip surgery, whereas 41 hips (36%) in patients with congenital dislocation of the hip and 28 hips (61%) in patients with fracture-dislocation of the hip had one or more ipsilateral surgical procedures prior to the arthroplasty. The sex ratio varied between the groups, with a male:female hip ratio of 1:1, 1:10, and 3:1 for the three groups, respectively. The risk of developing grades 2 or 3 heterotopic ossification after total hip arthroplasty were significantly higher in men, patients without postoperative treatment with antiinflammatory drugs, and patients above age 60. In contrast, the analysis documented that previous ipsilateral hip surgery and type of coxarthrosis did not influence lesion development, supporting the theory that a systemic, rather than local factor, is responsible for the development of heterotopic bone formation after total hip arthroplasty.

Adolescent↗
PubMed1990

[Comparative study of treatment of keratocysts by enucleation, enucleation combined with cryotherapy or fixation of the cyst membrane with Carnoy's solution followed by enucleation: a preliminary report].

Comparative study of treatment of keratocysts by enucleation, enucleation combined with cryotherapy or treatment with Carnoy's solution followed by enucleation: a preliminary report. The aim of this preliminary report was to compare the effect on the recurrence rate of keratocysts treated by enucleation (group E, 14 cysts), enucleation combined with cryotherapy (group EK, 14 cysts) or a fixing agent (Carnoy's solution) followed by enucleation (group CE, 10 cysts). A total of 32 patients with 38 keratocysts are included in the study. In group E 5 recurrences (36%) was developed after 17, 34, 36, 37 and 39 months postoperatively, whereas 5 recurrences (36%) after 22, 24, 24, 25 and 59 months was registered in group EK. Due to a rather high incidence of side effects to cryotherapy this treatment technique can not be recommended. No recurrences has been found in group CE, and usually complete bone healing has occurred after 6 to 12 months postoperatively. Due to the use of the strong fixing agent we recommend treatment by this method performed under general anaesthesia to secure an immobile surgical field. In accordance with recent studies, the results indicate that fixation before enucleation has revolutionized the art of treating keratocysts with respect to recurrence rate.

Adolescent↗