Search PubMed⌕ Search

Biomedical subjects

J Jagger

Publications and source records attributed to J Jagger.

At least 91 records · Page 5Linked to original sources
PubMed1986

Pathogenesis of pupillary capture after posterior chamber intraocular lens implantation.

Pupillary capture is an unusual complication of posterior chamber intraocular lens implantation and may occur in the early or late postoperative period. We describe a series of patients with early or late onset pupillary capture and describe the pathogenesis. Early capture results from mechanical factors and is usually preventable. Late capture may be mechanical but is usually a sequel to the formation and subsequent contraction of iridocapsular synechiae. Synechiae result from lens epithelial or iris stromal hyperplasia and myofibroblastic metaplasia; they may be minimised by an atraumatic technique and adequate control of postoperative inflammation. The effect of pupillary capture is largely cosmetic, and we encountered no specific complications attributable to it.

Aged↗
PubMed1984

Epidemiologic features of head injury in a predominantly rural population.

The characteristics of occurrence of head trauma were studied in north central Virginia. In 1978, 735 cases of head trauma were identified with documented head injuries occurring within the defined service area, and with a minimum overnight hospital stay. Overall occurrence was 208/100,000 population. The highest occurrence was found in the 15-19 age group (407/100,000). Nonwhites showed higher rates than whites. Motor vehicle crashes were the most frequent mechanism of injury (55% of patients) followed by falls (20%), and interpersonal violence (11%). Short-term time trends reveal unique daily, weekly, and seasonal patterns for motor vehicle crashes, falls, and interpersonal violence. Selected prevention strategies are discussed. The use of passive restraints in motor vehicles is recommended as one important means of reducing the occurrence and severity of head injuries.

Adolescent↗
PubMed1984

Effect of alcohol intoxication on the diagnosis and apparent severity of brain injury.

Because alcohol intoxication is common among brain-injured patients, we performed this study to determine the extent to which alcohol alters the initial assessment of brain injury severity in these patients by depressing the level of consciousness. The Glasgow coma scale was used to measure the level of consciousness of 257 brain-injured adults admitted to the University of Virginia Hospital, both on arrival in the emergency room and 6 to 10 hours later. Improvement in the level of consciousness between the first and second measurements was significantly related to the blood alcohol concentration on admission. Patients with the highest blood alcohol concentrations showed the greatest improvement. Most of this effect occurred in patients with a blood alcohol concentration of 0.20% or higher. Alcohol intoxication is a potential source of bias in the clinical classification of brain injuries according to severity.

Adolescent↗
PubMed1984

The contribution of brain injury to the overall injury severity of brain-injured patients.

Several recent population-based studies of the incidence of head injury have identified cases by screening hospitalized patients. This method assumes a close relationship between severity of head injury and overall injury severity, since it is the latter that determines hospital admission. Thus, a patient whose overall injury severity is high will be admitted to the hospital regardless of the degree of his head injury. Similarly, since a patient's outcome status after treatment depends on his response to all his injuries, studies of the prognosis of various types of head injury also assume a close relationship between head injury severity and overall injury severity. The present study examines the relationship between brain injury severity and overall injury severity in a series of hospitalized head-injured patients with evidence of actual or probable brain trauma. Among these patients, brain injury severity was closely related to overall injury severity. Head injury severity and head and neck injury severity were also closely related to overall injury severity. For all other body regions, injury severity was not closely related to overall injury severity in this group of patients.

Adolescent↗
PubMed1983

A new library for emergency medicine.

The publication of textbooks that are relevant to emergency medicine has increased rapidly during the past decade. This increase has created confusion in the selection of appropriate texts for both emergency medicine residency and hospital emergency department libraries. A critical review of 703 pre-selected texts was performed. From this review, a recommended list of 165 books for the resident library and 27 books for the emergency department library is suggested. The cost of these libraries is $6,433.05 and $1,230.05, respectively. The libraries are designed to assist emergency physicians and librarians in attaining maximum value in the expensive process of textbook selection.

Bibliographies as Topic↗
PubMed1982

The epidemiology of Tourette's syndrome: a pilot study.

A new, precoded, self-report questionnaire was used to collect information on 75 patient members of the Tourette Syndrome Association. This diverse group of Tourette's syndrome (TS) patients supplied by mail detailed medical, symptom, developmental, family, and personal history information. Analysis of these data supported the usefulness and validity of the questionnaire, and also indicated that the diagnosis of TS is being made earlier; attentional difficulties may be basic to the disorder; haloperidol is an effective treatment for many patients, but alternative treatments are needed because unpleasant side effects of haloperidol often lead to discontinued use, and TS is disabling for many with most patients reporting serious problems in one or more areas of functioning.

Adolescent↗
PubMed1981

Inducible repair of near-UV radiation lethal damage in E. coli.

We present here the initial characterization of a new repair system which is induced in actively growing cultures of Escherichia coli and which repairs a major fraction of lethal damage produced by near-UV (310-400 nm) light. This system is different from the error-prone 'SOS' repair system for DNA, known to be induced in E. coli by treatments which damage DNA and/or inhibit DNA replication, such as irradiation by far-UV (254 nm) light or X rays, thymine starvation or treatment with naladixic acid or mitomycin C. The SOS response requires induction of an 'X' protein, the product of the recA gene, whereas the inducible repair system described here utilizes proteins distinct from the X protein.

Bacterial Proteins↗
PubMed1981

Roles of the relA(+) gene and of 4-thiouridine in near-ultraviolet (344 nm) radiation inhibition of induced synthesis of tryptophanase in Escherichia coli B/r.

Near-ultraviolet radiation (near UV; 300-380 nm) is known to inhibit the induced synthesis of tryptophanase by tryptophan in Escherichia coli, showing an action spectrum similar to that for near-UV-induced growth delay. The present work shows that a relA mutant of E. coli B/r exhibits 50% as much monochromatic near-UV (334 nm) inhibition of tryptophanase induction as the wild type, and tht a mutant lacking 4-thiouridine, an unusual nucleoside in tRNA, exhibits greater than 10% as much inhibition of tryptophanase induction. These findings indicate that 4-thiouridine is almost the sole chromophore for this effect in E. coli B/r, but that only 50% of the effect operates by a mechanism utilizing the relA(+) gene product; growth delay appears not to be primarily involved.

Enzyme Induction↗