Biomedical subjects
J Jaeger
Publications and source records attributed to J Jaeger.
[Electron microscopic studies on human uterus musculature (for the innervation of smooth muscle cells)].
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[The extended gynecologic examination].
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Variations in the morphological substrate of the smooth muscle cells of the pregnant and non-pregnant human uterus.
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[On the ultrastructure of the myometrial connective tissue].
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[Vaginal cytodiagnosis for general practitioners].
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[Vaginal cytodiagnosis for general practitioners. (Results and evaluation of 11,433 sent specimens)].
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Violence and psychopathology: a longitudinal study.
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The measurement of subjective experience in schizophrenia: the Subjective Deficit Syndrome Scale.
The systematic assessment of subjective experience independently from its impact on schizophrenic's behavior is neglected in most structured interviews and symptoms rating scales. However, subjective complaints may predict outcome functioning, medication compliance, and future psychotic episodes and better reflects patients' well-being than does behavioral assessment. We demonstrate the reliability of the Subjective Deficit Syndrome Scale and the considerable prevalence of subjective complaints in 166 acute and chronic inpatients and outpatients. Complaints were correlated with global measures of psychopathology in acute but not chronic patients. They were not correlated with negative symptoms or neurological side effects. Some overlap was observed with measures of depression, although most patients denied depressed mood. We conclude that subjective deficits are prevalent in schizophrenia, that they can be reliably assessed, and that they constitute an independent, clinically important dimension of the disease.
Facial expression of positive and negative emotions in patients with unipolar depression.
Neuropsychological research in major depression has generally been limited to the realm of cognition. This study focuses instead on the neuropsychology of affect. Emotional facial expression was examined in light of its presumed right cerebral hemisphere mediation and evidence for right hemisphere disorganization in major depression. Posed facial emotional expressions of four emotions were elicited and dynamically photographed in 30 unipolar depressives and 30 normal controls. Accuracy and emotional intensity of the expressions were rated by blind raters. Depressed patients were significantly impaired in the production of emotional facial expressions, particularly for positive ones. Several alternative explanations for the findings are discussed and further studies recommended.
Expression, purification and secondary structure analysis of Saccharomyces cerevisiae vacuolar membrane H+-ATPase subunit F (Vma7p).
The vacuolar H+-ATPase is an acid pump found in virtually all eukaryotic cells. It shares a common macromolecular organization with the F1F0-ATPase, and some V-ATPase subunits are structural and functional homologues of F-ATPase components. However, the vacuolar complex contains several subunits which do not resemble F-ATPase subunits at the sequence level, and which currently have no specific function assigned. One example is subunit F, the Vma7p polypeptide of Saccharomyces cerevisiae. A recombinant form of Vma7p was expressed in Escherichia coli and purified to homogeneity. Mass spectroscopy confirmed a mass of 13460 Da for Vma7p, and dynamic light scattering showed that the polypeptide was globular and monodisperse even at high concentrations. Analysis of secondary structure by circular dichroism and FTIR showed that Vma7p comprises 30% alpha-helix and 32-42% beta-sheet. The protein fold recognition programme 'Threader 2' produced highly significant matches between Vma7p and five alpha-beta sandwich folds. Relative proportions of secondary structure elements within these folds were broadly consistent with the spectroscopic data. Although Vma7p does not share sequence similarity with the F-ATPase epsilon subunit, the analysis suggests that the polypeptides not only have similar masses and assemble into homologous core complexes, but also share similar secondary structures. It is possible that the two polypeptides are homologous and perform similar functions within their respective ATPases. The production of high yields of homogeneous, folded, monodisperse protein will facilitate high resolution crystallography and NMR spectroscopy studies.
Evaluation of methodological and biological influences on the collection and composition of exhaled breath condensate.
The purpose of this inter-species comparison (calves and pigs) was to identify methodological and biological influences on the collection and composition of exhaled breath condensate (EBC). A total of 352 EBC samples were collected, whilst variables of ventilation were registered in parallel. Partial pressure of carbon dioxide (pCO2) and pH were analysed in non-degassed EBC samples. The concentration of total protein in EBC was measured colorimetrically. In both species, lung function was evaluated before and after EBC collection. Statistical analyses were performed to study the effect of EBC collection on lung function and to identify the influence of ventilatory variables on the collection and composition of EBC. Collection of EBC did not affect lung function. Despite the volume of EBC collected per unit time being primarily dependent on ventilation per unit time, species-specific conditions during the EBC collection process resulted in different dependences of EBC collection from other variables of ventilation (i.e. maximal airflow during expiration or expired tidal volume kg-1 body weight). The concentration of protein ml(-1) EBC increased with the expired volume per min and with peak expiratory flow. Although the pCO2 in fresh EBC was significantly negatively dependent on the duration of collection, comparable pHs (5.6 - 6.2) were measured in EBC of both calves and pigs. The obtained data may help one standardize EBC collection in different species.
[Treatment of fractures of the trochanteric region by Ender nailing. Results of a continuous series of 120 cases].
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[Cognitive rehabilitation of psychotic patients].
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[Trends in inpatient geriatric psychiatry care in West Germany].
Studies in the U.S.A., Great Britain and Denmark have shown marked reductions in recent decades in the numbers of psychiatric hospital beds occupied by elderly patients. In order to examine the corresponding trends in psychogeriatric in-patient provision in the Federal Republic of Germany, a survey was undertaken of psychiatric admission and bed-occupancy rates for the elderly population in the different regions of the country since 1970. Because of the often incomplete nature of the available data, and the lack of comparability between the documentation and statistical returns in the various regions, no comprehensive or nation-wide overview of the situation is possible. In the few regions for which relatively complete data could be obtained, basically similar trends in psychiatric admission and bed-occupancy rates could be demonstrated. While the annual rates of admission and the numbers of treatment episodes have continued to increase, the psychiatric bed-occupancy rates appear to have undergone a large reduction. The rate per 1000 persons aged over 65 years fell in Hesse from 3.0 to 1.7 (or 43%) in the period 1971-1982; in Schleswig-Holstein from 2.8 to 2.1 (or 25%) between 1971 and 1979, and in North Rhine-Westphalia from 1.8 to 1.4 (or by 22%) in 1974-1982.(ABSTRACT TRUNCATED AT 250 WORDS)
[The demand for homes in old age].
A study is reported of the utilization of non-clinical institutional care (geriatric and old people's homes) by the elderly inhabitants of Mannheim (pop. 306,000). The aim of the research was to establish the probability of admission to institutional care of an elderly person from this population, and to examine the influence of socio-demographic features. Under the West German health insurance system, most of the long-stay care of the elderly is provided not in hospitals but in nursing and geriatric homes. Data were collected on age at admission, place of residence before admission, duration of stay, age at death and place of death, as well as on the financial basis of care. The data were gathered retrospectively, the sample consisting of all inhabitants of Mannheim over 65 years old who died in the year 1982 (N = 2,585). At any given time only about four per cent of the elderly population will be in institutional care. In this respect, Mannheim is typical for the Federal Republic of Germany. However, the research findings demonstrate that approximately one elderly person in five will spend the last period of his life in this type of care. Seen in this light, the geriatric and old people's homes acquire a much greater social significance than is revealed by the number of institutional places alone.