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Biomedical subjects

J Jacobi

Publications and source records attributed to J Jacobi.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Fluoride contents of rat molars following the administration of amine-fluoride-containing caries preventives (author's transl)].

Experiments on fifty Wistar rats were conducted with the object of studying the incorporation of fluoride into the enamel of molars subsequent to the administration of amine-fluoride-containing caries preventives. - Use of two toothpastes with low fluoride contents of 0.125% and 0.18% F, respectively, and two higher-fluoride (1% F) solutions resulted in a marked increase in the concentration of fluoride in the superficial layers of dental enamel.

Animals↗
PubMed1978

[Evaluation of the cadmium content in sedimented and floating dust as factors in contamination of the biosphere].

In a territory being 3.500 km2, the cadmium deposits from the atmosphere were determined at 63 sites in 52 towns and communities. These determinations yielded a mean value ranging from 0.13 to 0.15 mg/m2 . 30 d. On the contrary, the mean value (-x) was 0.33 mg/m2. 30 d in the region of heavy-metal-emitting industries. The mean cadmium content in the aerosol was between 0.003 and 0.004 microgram m-3 and, respectively, 0.016 microgram m-3 in case of cadmium emission. It was calculated that the mean proportion of cadmium in the sedimentary dust was between 13 and 16 p.p.m. The cadmium burden, as estimated as cadmium sediment, correlated with the extent of the developmental area. The authors recommend for the present the following maximum permissible values: 0.05 microgram m-3 in the aerosol, and 0.15 mg/m2. 30 d. The cadmium content in the sedimentary dust may be considered to be a permanent burden applied via the food chain, whereas the content in the aerosol is of less importance to the total uptake in man. The calculation of the daily pulmonary uptake yielded a value of 0.075 microgram, from which an absorption of 0.038 microgram is estimated.

Air Pollutants, Occupational↗
PubMed1977

Onset of oestrogen-induced prolactin secretion and DNA synthesis by the rat pituitary gland.

The times of onset of oestrogen-induced prolactin secretion and DNA synthesis were studied in the pituitary gland of the male rat. At intervals from 3 to 96 h after injection of 10 mg diethylstilboestrol dipropionate, serum and pituitary prolactin concentrations were measured by radioimmunoassay and pituitary DNA synthesis by incorporation of [3H]-thymidine in vitro. Serum prolactin was raised significantly from 6 h onwards and DNA synthesis was increased from 30 h onwards. Pituitary prolactin concentration began to increase at 30 h. Significant correlations were obtained between serum prolactin and DNA synthesis from 24 to 72 h but not during the period of prolactin secretion from 6 to 24 h.

Animals↗
PubMed1977

Hyporeninemia and hypoaldosteronism in diabetes mellitus.

The changes in plasma renin activity (PRA) and plasma aldosterone concentration (PA) in response to postural stimuli were evaluated in 12 patients with stable diabetes mellitus and in five volunteers. Seven diabetic patients had hyperkalemia, and several had renal insufficiency and neurological complications. Five diabetics and had normal serum potassium concentration, a mean creatinine clearance within the normal range, and few complications. PRA and PA were measured in these patients and in the control subjects, all of whom were receiving a diet containing 10 mEq of sodium and 50 mEq of potassium while they were in a supine position, after they were tilted to a 90 degrees position, and after upright posture for two hours. The results indicate that impaired responsiveness of PRA and PA may occur in patients with complicated and those with uncomplicated diabetes and may be responsible in part for a relatively high prevalence of hyperkalemia especially in those diabetic patients with reduced renal function.

Adult↗
PubMed1976

[Lead content of vegetable foods in vicinity of lead emitting industry].

By means of atomic absorption spectrophotometry, the authors determined the lead content in vegetable, fruit and soil samples from the environments of a lead-smelting plant. The lead values obtained were some 10- to 100-fold higher than those found normally. The mean lead content in vegetables varied from 2 to 150 p.p.m. in dry matter; that in fruits, from 4 to 35 p.p.m. Lead concentrations ranging from 575 to 2900 p.p.m. were detected in the soil samples. The mean lead content in the atmosphere was between 0.62 and 0.95 mug/m3 (maximum value 12 mug/m3). From these data it was calculated that the total resorption of lead from vegetables, fruits, potatoes and air varied from 0.04 to 0.49 mg/day in the territory under investigation. To protect the population against increased intake of lead, it is recommended to abandon individual and commercial vegetable and fruit growing, especially leaf vegetables. Since the contamination of the soil persists for generations, the authors discuss its replacement by non-contaminated surface soil.

Air Pollution↗