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Biomedical subjects

J J Thomas

Publications and source records attributed to J J Thomas.

At least 19 recordsLinked to original sources
PubMed1995

Reducing anxiety during phase I cardiac rehabilitation.

Anxiety can produce undesired effects in patients recovering from cardiac conditions including coronary artery bypass grafting surgery. Pharmacological, psychological and educational interventions are used to reduce patient anxiety. This study compared the effects on state anxiety of participation in one of two Phase I (in-patient) educational interventions for patients undergoing their first coronary artery bypass grafting surgery. Subjects (n = 96) were randomly assigned to either a traditional, staff-directed intervention or an intervention based on a collaborative approach. Eighty subjects were included in the data analyses. Results demonstrated that subjects in the collaborative-based intervention had significantly less state anxiety at hospital discharge than those in the traditional intervention. The collaborative approach offered patients opportunities to address individually identified concerns regarding recovery and future functioning and to exert control over facets of their hospitalization experience.

Adult↗
PubMed1994

Using rubber dam.

Explore the source record for details and available documents.

Deglutition↗
PubMed1988

Color graphics representations of large sequences in the GEM environment.

The analytical and descriptive color graphics capabilities (the GEM environment) of the CAGE/GEM(a) software system are described using bacteriophage lambda (48,502 base pairs) and Epstein Barr virus (172,282 base pairs) as examples. Genetics and features, as graphic drawings, and the results of sequence analysis as pseudo-colored representations, are simultaneously displayed at all zooming levels. The present upper limit on sequence size is 5 x 10(5) bases. The overlay editor utility which provides the capability to structure complex sequence associated data and knowledge bases into a manageable color graphics format is also described. Holistic correlations that can be made by the display of bacteriophage lambda and Epstein Barr virus in the GEM environment are also discussed.

Bacteriophage lambda↗
PubMed1986

Cloning simulation in the cage environment.

The CAGE/GEM(TM) software toolkit for genetic engineering is briefly described. The system functionally uses color graphics and is menu driven. It integrates genetics and features information ("Overlays") with information based on sequence analysis ("Representations"). The system is structured around CAD (Computer Aided Design) principles. The CAGE (Computer Aided Genetic Engineering) aspects of the software are emphasized and illustrated by a simulated cloning of the hepatitis B core antigen gene into the BAMHI site of plasmid pBR322.

Base Sequence↗
PubMed1976

Growth and subculture of pathogenic T. pallidum (Nichols strain) in BHK-21 cultured tissue cells.

The growth and nine subcultivations of the experimental Nichols strain of pathogenic Treponema pallidum were successfully accomplished in cultured baby hamster kidney tissue cells (BHK-21) using serum-free media. The number (motile and non-motile cells occurring extracellulary) of cell generations generally increased with each subcultivation, the largest increases (greater than 3-0) occurring in subcultures 4, 5, 7, 8, and 9. Also, the number of motile cells decreased with each subcultivation. Virulent organisms were demonstrated in subcultures 1, 4, 5, 7, and 8, and their numbers estimated with the use of standards established by the animal inoculation titration of counted numbers of organisms freshly harvested from experimental infections; the estimated number of virulent organisms was higher than or equal to the counted cultivated treponemes injected, which may be attributable to uncounted virulent spirochaetes occurring intracellularly.

Animals↗
PubMed1976

The effects of glucosamine derivatives on the growth of cultivable Treponema.

The effects of glucosamine and its derivatives on the growth of Treponema phagedenis biotypes reiter and kazan 5 were studied to determine if these agents could act as growth stimulants for organisms of the genus Treptonema. Growth studies on the cultivable treponemes were conducted in culture tubes containing glucosamine, glucosamine derivatives, and (or) glucose and galactose in serum-based media. Glucosamine and N-phenylacetylglucosamine were definitely inhibitory to growth at the concentrations studied. N-acetylglucosamine (NAG) produced mixed effects.

Acetylglucosamine↗
PubMed1975

Complete Klüver-Bucy syndrome in man.

A 22 year old right-handed man suffered a viral meningoencephalitis, possibly herpetic, resulting in bilateral damage to the temporal lobes as confirmed by appropriate clinical, electrophysiological and neuroradiological studies. Extended clinical neuropsychological evaluation documented all the characteristic features of the syndrome described by Klüver and Bucy following bilateral ablation of the temporal lobes in adult Rhesus monkeys, including "psychic blindness," oral exploration, hypermetamorphic impulse to action," lack of emotional responsiveness, aberrant sexual behavior, and an insatiable appetite. Additionally, a severe Wernicke's aphasia and a profound memory disorder were evident. The significance of these features as regards limbic function in the human is discussed.

Adult↗
PubMed1966

Interactions of oxygen at high pressure and radiation in Drosophila.

Oxygen at high pressure (OHP) and X-irradiation can interact in the fruit fly Drosophila melanogaster to potentiate toxic actions characteristic of one agent alone. 1000 kvp X-irradiation in doses of 30, 60, and 75 kr accelerated the acute immobilization of young male Drosophila by oxygen at 7.8 atm, up to rates twice that observed with such oxygen pressure alone. X-irradiation alone in these dosages did not acutely immobilize the Drosophila. X-irradiation during exposure to 7.8 atm pO(2) was more effective and consistent in producing this potentiation than was X-irradiation that preceded exposure to OHP. Acute OHP toxicity in young female Drosophila was not potentiated by 75 kr of X-irradiation. On the other hand, shortening of the life span of young male Drosophila by the above doses of X-irradiation was augmented significantly by a concurrent 40 min exposure to OHP (which alone did not significantly decrease life span). This shows, for the first time, that oxygen can affect not only the acute effects of radiation, but also the residual irreversible effects indicated by the life span shortening.

Animals↗