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Biomedical subjects

J J Sziklas

Publications and source records attributed to J J Sziklas.

At least 37 records · Page 2Linked to original sources

Varied appearance of cardiac pseudoaneurysms on blood pool images.

Three cases of cardiac pseudoaneurysms were presented, with findings at the time of gated blood pool imaging. In only one of three was there the finding of a small neck connecting the ventricular cavity with the pseudoaneurysm. In the other two patients, there was a considerably larger communication. The size of the pseudoaneurysm itself was also of little diagnostic assistance. In one case it was small, while in a second patient it was larger in size. The third case revealed a pseudoaneurysm of enormous size (larger than the ventricular cavity). Gated blood pool imaging apparently can be called upon to demonstrate the presence of an abnormality. It may not be able to definitely establish the diagnosis of pseudoaneurysm, but should suggest the use of cardiac angiography to distinguish these life threatening lesions from true aneurysms.

Aged↗

Recovery of femoral head perfusion after drainage of septic joint.

A 64-year-old woman was febrile and had pain near the right hip. Blood cultures grew beta hemolytic streptococci. A bone scan showed reduced activity in the right femoral head and neck compared with the left femoral head and neck. She was treated with intravenous antibiotics and surgical decompression of a tense and bulging right hip joint. Five days later, a repeat bone scan revealed much of the femoral head activity to have returned. By day 20 after the initial bone image, there was intense activity throughout the femoral head and neck. Prompt relief of a distended hip joint can result in reperfusion of the femoral head and neck.

Arthritis, Infectious↗

Rapid response of intrasplenic lesions to steroids in non-Hodgkin's lymphoma.

A 70 year old woman had a [99mTc]sulfur colloid liver/spleen scan that showed splenomegaly and multiple intrasplenic defects. The lesions failed to concentrate radiogallium. Thirteen days later, after being on steroid therapy, the spleen had decreased in size and the lesions were only barely apparent. The intrasplenic process, due to non-Hodgkin's lymphoma, was thus markedly sensitive to steroids. It is uncertain if such rapid regression can be employed as a prognostic indicator in non-Hodgkin's lymphoma and suggests the need for further monitoring. The differential diagnosis of the rapid response of intrasplenic lesions to steroids is a limited one, and likely includes sarcoidosis.

Aged↗

Dual radionuclide subtraction imaging of the spleen.

Dual radionuclide subtraction imaging of the spleen using 67Ga citrate and 99mTc is useful in further delineating lesions that are identified on either a routine radiogallium survey or on a conventional sulfur colloid liver-spleen image. Better anatomic localization of left subphrenic abscesses may be obtained. Differentiation of tumors and abscesses from less serious lesions such as cysts, infarcts, and hematomas is possible. We have found this technique to be generally applicable to any organ that can be selectively imaged using a technetium radiopharmaceutical, including the liver, bones, and kidneys. In addition, we are currently evaluating thallium-pertechnetate subtraction imaging in the evaluation of parathyroid adenomata.

Aged↗

Incidental finding of intense thyroid radiogallium activity during febrile illness.

Two elderly adults presented with fever of undetermined origin. Radiogallium imaging showed intense concentration in the thyroid, without abnormal localization elsewhere. In the first case, a repeat radiogallium study performed three weeks later was within normal limits. The patient had 0% uptake of radioiodide, and no demonstrable iodine within the thyroid. This probably represented thyroiditis. In the second case, an elevated T4 (RIA) and borderline elevated T3 resin uptake suggested the "dumping phase" of thyroiditis. The two cases indicate that "benign" diseases of the thyroid can be associated with diffuse radiogallium concentration in the gland.

Aged↗

Delayed splenic rupture: a suggestion for "predictive monitoring".

Two cases of delayed splenic rupture are presented. In one, splenic damage was demonstrated on Day 29 following trauma, and rupture of the organ occurred 2 days later. In the second patient, splenic trauma was documented 1 day after an accident, and rupture occurred on Day 26. Each case was marked by the fact that only one spleen scan had been performed (in the first case because of discovery only long after the trauma, and in the second case because of the patient's failure to return). That is, while damage to the spleen was evident, there was no follow-up to document healing. Based on this, it is suggested that spleen imaging be carried out soon after trauma. If a trauma-related defect is shown, then a repeat study may be mandatory to document healing. Lack of such healing, or failure to progress at a normal rate, may be an altering sign to impending splenic rupture. Hence, "predictive monitoring" by early and then repeat imaging at a later date, is proposed.

Adolescent↗