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Biomedical subjects

J J Seebode

Publications and source records attributed to J J Seebode.

At least 19 recordsLinked to original sources
PubMed1997

Stressful life events and risk of symptomatic kidney stones.

BACKGROUND: It has been reported that a substantial proportion of cases of hypercalciuria and nephrolithiasis are idiopathic. Several studies suggested that stressful life events increase lithogenic urinary constituents (calcium, oxalate and uric acid). OBJECTIVE: To test the hypothesis that there is an association between stressful life events and symptomatic kidney stone. METHODS: A case-control study of 200 symptomatic kidney stone cases and 200 matched controls was designed to test the hypothesis. In this study, the stressors include those life events that the subjects perceived as highly stressful and inflicted upon them an intense emotional impact with apprehension and distress for at least one week in duration. RESULTS: Ten of eleven (91%) categories and 41 of 60 (68%) subcategories of stressful events occurred more frequently among cases than controls. Eighteen stressful events had odds ratios of 1.5 or greater. Of the seven significant (P < 0.05) variables that were entered into a multivariate logistic regression model, the following three remained statistically significant between cases and controls: annual family income (lower for cases); stressful morgage problems; and emotional life events. CONCLUSION: The overall prevalence rate of stressful life events was significantly (P < 0.00001) higher among cases than controls. The data support the hypothesis that there is an association between stressful life event(s) and symptomatic kidney stones.

Adolescent↗
PubMed1993

Obstructed solitary pelvic kidney and urinary ascites.

We report on a patient with a congenital pelvic kidney who presented with anuria and urinary ascites. Extensive pelvic endometriosis involving the ureteropelvic junction was the cause of severe obstruction. We discuss successful management of this condition and review the literature.

Adult↗
PubMed1991

Synergistic effects of follicle-stimulating hormone and testosterone on the maintenance of spermiogenesis in hypophysectomized rats: relationship with the androgen-binding protein status.

The present study examined the relationship between the functional status of Sertoli cells and the maintenance and restoration of spermatogenesis in immature hypophysectomized (HPX) rats given various doses of exogenous testosterone with or without daily injections of FSH for 90 days. Subcutaneous implantation of a 2- to 10-cm testosterone capsule (TC) increased serum testosterone levels of HPX rats 2-10 times above the normal control levels, but did not significantly increase the testicular testosterone level. Daily injections of FSH significantly increased the accumulation of testosterone in testes of TC-implanted HPX rats. Maintenance of early spermiogenesis was observed in all TC-implanted animals. Although elongated spermatids were present, step 18-19 spermatids at the luminal edge of stages VII-VIII epithelium were only observed in rats bearing 10-cm TC implants. Daily injection of FSH resulted in the completion of spermiogenesis in all TC-implanted animals, and the number of step 18-19 spermatids was dependent on the length of TC implants used. These results demonstrate the importance of the synergism of FSH and testosterone in the final steps of spermiogenesis. The androgen-binding protein (ABP) content per testis of the HPX rats was stimulated by TC implants. However, a significant increase in epididymal ABP was only noted in rats bearing 10-cm TC implants. Injection of FSH resulted in a significant increase in the testicular ABP content in rats bearing 2- or 5-cm TC, but not in those with 10-cm TC implants. In addition, the epididymal ABP content was significantly stimulated by FSH in all TC-implanted animals. The ABP status in the testis and its transport toward the epididymis are closely related to the extent of maintenance of spermiogenesis. It is speculated that the production of ABP by Sertoli cells and the biochemical properties of ABP molecules may have some role in the control of the final steps of spermiogenesis.

Androgen-Binding Protein↗
PubMed1988

Experiences with an artificial sphincter to establish anal continence in dogs.

An implantable device for establishing urinary continence has been developed and has received FDA approval (AS 800, American Medical Systems, Inc.). The authors have applied this device to the control of anal continence in dogs. Fifteen mongrel dogs underwent either anal sphincter disruption (7) or abdominal-perineal resection (8). Such animals have bowel movements almost hourly. In each case, the device was implanted at the time of surgery. In dogs with working cuffs and disabled or absent sphincters, continence was maintained in seven out of 15 animals for periods of 4-8 hours. After cuff activation, intraluminal cuff pressures of 50-70 cm of water achieved continence for a period of 8 hours. In animals sacrificed from 1 to 12 months after implantation, the device was found to be well tolerated by the body with minimal fibrosis of the mucosa or muscularis of the bowel. Complications observed in the same four out of 15 animals during the study period were infection, device extrusion, and device malfunction. Infection resolved with local wound care and antibiotics (3/4) and the device was successfully replaced in two out of four instances of extrusion. With cuffs of proper size and pressure, this appliance may be effective in the control of human anal incontinence via the establishment of continent perineal colostomies following an abdominal-perineal resection.

Animals↗
PubMed1987

Plasmacytoma of the testis.

We report a case of plasmacytoma of the testis without evidence of bone or immunoglobulin abnormalities. The presentation, evaluation and management of this extremely unusual tumor are reviewed.

Humans↗
PubMed1984

Replacement of partially resected canine urethra by polytetrafluoroethylene.

Twelve Gore-Tex grafts were used to replace a section of the urethra in 10 dogs. The grafts functioned well for three months, but at six months there was calcification and fistula formation. A fibrous tube developed around the grafts rather than a regenerated urethra. There was no epithelial regrowth on the internal surface.

Animals↗
PubMed1982

Life time occupation, smoking, caffeine, saccharine, hair dyes and bladder carcinogenesis.

A case-control study of bladder cancer in two northern counties of New Jersey was conducted to investigate a tumour that has been considered to be strongly associated with industrial and environmental exposures. The study population included 75 bladder cancer cases and 142 controls. Cases and controls were matched for race, sex, age, place of birth and place of residence. Statistically significant associations with bladder cancer and risk ratios of greater than 2.0 were found for cigarette smoking and for working in dye, petroleum (fuel) or plastics industries. No statistically significant association was found for: cigar and pipe smoking; caffeine, saccharine and alcohol consumption; and life time occupational history of working in other than dye, petroleum and plastics industries. No statistically significant differences between cases and controls were found in family history of cancer. Risk ratios of at least 2.5 (but without statistical significance possibly because of sample size) were found for workers in rodenticide and printing industries, for cable workers and for cancer in the spouses of bladder cancer cases. Simultaneous multiple primary cancer sites were found in 9.3% of the bladder cancer patients; this is higher than the 0.2-8% reported in the medical literature. The life time occupational history of the bladder cancer cases points to industrial determinants: some are known (petroleum and dye industries) but the association with the plastics industry is new. If our findings are confirmed, investigations will be needed to determine whether any specific chemical or combination of chemicals used in the plastics industry is responsible for bladder cancer induction.

Alcohol Drinking↗
PubMed1981

Study of renal blood supply and its implication in renal pelvic surgery.

Studies of the blood supply and healing potential of the renal pelvis were correlated. Angiographic studies of anatomic dissection of the blood supply, performed following an injection technique, proved that branches from the renal, lumbar, capsular, and ureteral arteries result in an abundant capillary supply. Comparison of healing after longitudinal and trnsverse incisions showed no significant difference.

Angiography↗
PubMed1980

Selective spermatic arteriography for localization of an impalpable undescended testis.

Thirty patients with undescended testes, including 15 children, were studied by selective spermatic angiography. Six patients had both arteriography and venography, and 24 had bilateral arteriography for assessment of testicular size. In 7 patients, arteriography revealed an impalpable testis following unsuccessful surgical exploration. In 17, subsequent surgery confirmed the angiographic findings; testicular agenesis was diagnosed in 7, and catheterization failed in 2. There were no complications. Preoperative testicular arteriography localizes the testis, facilitates surgery, and may aid in tumor detection. Angiographic identification of testicular agenesis precludes exploration. Arteriography is more accurate, simpler, and less complicated than venography.

Adolescent↗
PubMed1979

Familial occurrence of testicular neoplasms (in cousins).

Testicular malignancies in closely related family members rarely occur. Only 18 cases have been reported in the literature. Our cases concern two families with testicular tumors occurring in cousins. This is the first such incidence reported. The need for a thorough checkup of other family members is reiterated.

Adolescent↗
PubMed1979

Plasma androgens and estrogens in paraplegic men.

The plasma testosterone, estrone (E1), and estradiol (E2) levels were measured in paraplegic men and age-matched controls. Sephadex LH-20 columns and the celite technique were used to extract the sex steroids and a radioimmunoassay was used to measure them. Leydig cell stimulation was achieved with human chorionic gonadotropin administration.

Adult↗
PubMed1978

Iglesias articulated endoscopy teaching attachment.

A new articulated teaching attachment with a single joint is described. The attachment allows a 360-degree rotation in 3 planes (sagittal, horizontal and frontal) by the 3 rotary unions at the single joint with only 2 tubes. Simultaneous observation by 2 persons and the operator is achieved by combining 2 of these optical units. The attachment may be sterilized by soaking. It can be dismantled for cleaning and for replacement of any damaged parts. Finally, it facilitates taking still photographs, movies and television endoscopy without interference to the operator.

Endoscopes↗
PubMed1978

Anti-arcing loop and resectoscope.

A new modified cutting loop assembly and a modification of the resectoscope to prevent arcing between the bare wire loop and the distal end of the telescope are described.

Electrosurgery↗
PubMed1977

Hydraulic hemostasis in transurethral resection of the prostate using the Iglesias continuous suction resectoscope.

An intravesicoprostatic hydrostatic pressure less than 10 mm. Hg maintains normal anatomy and physiology of the muscular and vascular prostatic structures. An increase in hydrostatic intravesicoprostatic pressure to more than 10mm. Hg produces a distortion in the musculature of the prostate, especially at the true capsule, opening the cut vessels and making possible the absorption of the irrigant free of electrolytes (transurethral resection syndrome). A low hydrostatic intravesicoprostatic pressure permits the compression of cut vessels by the inflow hydraulic pressure of 90 cm. water, achieving hydraulic hemostasis during transurethral resection of the prostate. Less electrocoagulation is necessary, resulting in more rapid patient recovery.

Hemostasis, Surgical↗