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Biomedical subjects

J J Sanger

Publications and source records attributed to J J Sanger.

29 records · Page 2Linked to original sources

Lymphedema in the replanted limb of the rat: scintigraphic evaluation.

The sequence of scintigraphic patterns in resolving lymphedema in the replanted hind limb of the rat is reported. Compared to simple observation of the limb, scintigraphy using 99mTc-antimony trisulfide colloid (99mTc SbSC) provides multiple qualitative parameters for assessing lymphedema, ie, diffuse uptake in the implanted limb, focal uptake at the site of surgical repair, accumulation in the popliteal node, and activity in the liver. Quantitative analysis in this model was not helpful. Scintigraphic criteria may be utilized to study the effect of alteration in the animal model described. It is hoped that this model can be used to clarify the clinical factors influencing the resolution of lymphedema.

Animals↗

81mKr gas and 99mTc-MAA V/Q ratio images for detection of V/Q mismatches.

Methods for creating ventilation/perfusion ratio images have been reported previously using radioxenon. With the availability of 81mKr gas, corresponding ventilation and perfusion views in multiple projections to evaluate for V/Q mismatch may be performed more readily. A technique for the creation of a functional V/Q ratio image to highlight V/Q mismatches to aid in the evaluation of pulmonary embolism is described. By removing nonpertinent and distracting information and by converting a 'cold spot' imaging modality to a 'hot spot' modality, these functional images aid in the synthesis of the information provided by the ventilation and perfusion images. The limitations due to technical artifacts and the advantages of using these functional images are described.

Humans↗

Radionuclide scanning--new applications in urology.

The current status of nuclear renal scanning and function evaluation is summarized. The indications for renal imaging are discussed. Techniques for measurement of split and total renal function are reviewed. Special attention is given to the role of renography (conventional and diuretic) in the evaluation of the obstructed kidney.

Adult↗

Detection of lacrimal gland infiltration on routine bone scintigraphy.

We report a bone scan finding of bilaterally and symmetrically increased uptake at the lateral orbital rims in a patient with disseminated Hodgkin's disease. Computerized axial tomography (CT) demonstrated lacrimal gland enlargement, presumably due to infiltration by Hodgkin's disease. Both the radionuclide bone scan and CT findings, as well as the other physical and radiographic manifestations of Hodgkin's disease, resolved after chemotherapy. Infiltration by Hodgkin's lymphoma is a rare cause of lacrimal gland enlargement. We believe that this pattern of uptake on a routine bone scan should alert the physician to possible lacrimal gland disease, which could then be more definitively evaluated by CT examination.

Adult↗

Pseudomembranous colitis: a possible role for Gallium scanning.

A case of antibiotic-associated pseudomembranous colitis is presented in which the Gallium scan was the first diagnostic modality to alert the clinicians to the existence of an inflammatory bowel process. The mechanism of localization of the radiopharmaceutical in inflammatory bowel disease is discussed. Although colonoscopy is far more specific and should be the first-line diagnostic tool used in assessing the presence of pseudomembranous colitis, Gallium scanning may have a role in the follow-up of treatment and in cases of relapse.

Clindamycin↗