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Biomedical subjects

J J Purcell

Publications and source records attributed to J J Purcell.

At least 19 recordsLinked to original sources
PubMed1993

Topical cyclosporin A in the treatment of anterior segment inflammatory disease.

Topical cyclosporin A was used in the management of 43 patients with a variety of anterior segment inflammatory disorders that had failed corticosteroid treatment. Treatment with topical cyclosporin A ranged from 1 week to 43 months, with a mean treatment period of 13 months. Thirty-five patients (81%) with disorders including high-risk keratoplasty, atopic and vernal keratoconjunctivitis, ligneous conjunctivitis, ulcerative keratitis, and Mooren's ulcer had a beneficial result, with resolution, reduction, or prevention of inflammation. Six patients (14%) with scleritis, ocular cicatricial pemphigoid, or endothelitis showed no clinical improvement. Two patients (5%) had significant ocular discomfort, and the drug had to be discontinued in them. None of the other patients developed local side effects. Twenty-seven of these patients were followed with serial cyclosporin A blood levels and serum creatinine. None of these patients developed measurable drug blood levels or renal toxicity.

Administration, Topical↗
PubMed1984

Conjunctival lesions in periarteritis nodosa. A clinical and immunopathologic study.

Periarteritis nodosa is a disease with protean manifestations, yet there are few reports of ocular involvement. We treated a patient who was seen with conjunctival and anterior uveal involvement. The clinical histopathologic and immunopathologic characteristics are described. Immunopathologic studies are a useful adjunct in confirming the nature of this disorder.

Aged↗
PubMed1984

Orbital malignant melanoma and oculodermal melanocytosis: report of two cases and review of the literature.

Oculodermal melanocytosis is a congenital melanoblastic hamartoma affecting ocular tissues and facial skin. It is seen more commonly in oriental and black patients. Malignant degeneration, once believed to be rare in this syndrome, occurs in 4.6% of all reported cases, and is more frequent in whites. The actual incidence of malignant melanoma in this syndrome is difficult to determine as many uncomplicated cases go unreported. The most common site of malignant melanoma associated with this entity is in the choroid. Four previously described orbital tumors represent the second most frequent area of presentation. A review of the literature in this disease is discussed as well as a new case of orbital malignant melanoma associated with it. A second case of presumed orbital melanoma associated with oculodermal melanocytosis is also discussed.

Adolescent↗
PubMed1983

Lattice corneal dystrophy associated with familial systemic amyloidosis (Meretoja's syndrome).

A 79-year-old white man of Irish descent presented with lattice corneal dystrophy, blepharochalasis, and peripheral seventh cranial nerve palsies. Family studies revealed that his 23-year-old daughter had early lattice cornea dystrophy. The corneal button removed by penetrating keratoplasty exhibited characteristic amyloid accumulation by light and electron microscopy. Biopsy of the patient's normal appearing conjunctiva and skin of the lower lid revealed amyloid. Biopsy of the daughter's conjunctiva was negative for amyloid, but her lid skin had characteristic amyloid deposits by light and electron microscopy. Immunoperoxidase strains were negative for AA and AP and serum prealbumin and SAA proteins were normal. Meretoja's syndrome has rarely been described outside a small geographic region in Finland. The clinical and histopathologic findings of this entity are discussed and contrasted to isolated "lattice corneal dystrophy."

Aged↗
PubMed1982

Conjunctival immunopathologic and ultrastructural alterations. Occurrence in Reiter's syndrome.

Immunoprotein deposition has been demonstrated in the synovium of patients with Reiter's syndrome. Because of this fact and the controversy regarding the nature and cause of the conjunctivitis in Reiter's syndrome, conjunctival biopsy specimens were taken from eight patients with classic Reiter's syndrome. These specimens were examined histopathologically, immunopathologically, and ultrastructurally. Our findings indicated that perivasculitis and vasculitis were present, preponderantly with elements of the cell mediated immune system. Genetically susceptible persons (namely, those with positive HLA-B27 antigen) exposed to an agent (Shigella or Chlamydia) may trigger an immune response in which vasculitis and perivasculitis plays a predominant role.

Arthritis, Reactive↗
PubMed1981

Orbital myositis after upper respiratory tract infection.

Two cases of isolated unilateral extraocular muscle myositis after antecedent upper respiratory tract infections are reported. Pain, inflammation over the involved muscle, restricted motility, and an enlarged muscle on computerized axial tomography scan are the findings. This is differentiated from conjunctival inflammatory disease and neurologic disorders. The treatment is orally administered steroids.

Adult↗
PubMed1980

Inheritance of endothelial dystrophy of the cornea.

64 families containing a proband with corneal endothelial dystrophy were examined in order to study the hereditary nature of the disease. Data concerning the frequency of occurrence, severity of the disease, ratio of affected females to males, relationship of the disease with age, and other factors were the subject of a previous report. 7 pedigrees which reflect features of endothelial dystrophy within the 64 families are presented. These features include multiple females in a family being affected, multiple consecutively affected generations, the occurrence of offspring with disease more severe than the parent, and endothelial decompensation (edema) at a relatively young age (less than 40 years of age). The importance of examining family members whenever possible rather than relying on history alone is emphasized. A statistical analysis of the inheritance pattern was performed. Endothelial dystrophy does not seem to follow a strict autosomal dominant pattern even though superficial inspection suggests autosomal dominant inheritance (both males and females affected, successive generations affected, 38% of relatives over the age of 40 years affected). Even though we were unable to determine a specific genetic mode of inheritance in these 64 families with endothelial dystrophy, we do feel that endothelial dystrophy is at least in part an inherited disease. Future investigations might prove sex-linked dominance, genetic heterogeneity, the influence of environmental factors, or a multifactorial etiology.

Adult↗
PubMed1979

Familial corneal hypesthesia.

A 4-year-old boy with severe, diffuse, asymptomatic, punctate, epithelial corneal erosions had bilateral sharply decreased corneal sensation with normal skin sensation in the distribution of the trigeminal nerves. Subsequent family studies disclosed five family members with similar corneal changes and decreased corneal sensation and no punctate erosions. None had decreased skin sensation in the distribution of the fifth cranial nerve. No environmental factors or evidence of local or systemic disease accounted for these findings.

Adolescent↗
PubMed1979

The effect of unsuspected carotid-cavernous fistula in enucleation.

An 18-year-old man with an unsuspected carotid-cavernous fistula underwent enucleation as the result of a severe localized perforating ocular trauma. Potentially lethal bleeding occurred that was difficult to control. Auscultation of the orbit should be performed in all cases before eye enucleation to avoid the possibility of overlooking a carotid cavernous fistula.

Adolescent↗