Biomedical subjects
Publications and source records attributed to J J O'Brien.
Unusual helically-curved bacteria isolated from porcine and bovine abortions measured 1.8 microns long and 0.4 microns wide, failed to produce poly beta-hydroxybutyric acid granules and had DNA base compositions within the span 29--34 moles per cent. From this evidence, it was concluded that these organisms are members of the genus Campylobacter.
Antibodies to Leptospira serotypes were detected in sera from 15 (6.9 per cent) of 218 aborted fetuses, but were not detected in the sera from 196 non-aborted fetuses. Fourteen (6.4 per cent) sera from the aborted fetuses had antibodies to strains belonging to the Hebdomadis serogroup and 1 (0.5 per cent) had antibodies to a strain belonging to the Icterohaemorrhagiae serogroup. These antibodies were predominantly immunoglobulin M whereas in the dams, antibodies belonged to both immunoglobulin M and G classes.
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We report a series of 88 patients in whom 119 obstructing inferior nasal turbinates were resected for airway obstruction, and who have been followed for 3 months to 3 years. The airways were consistently improved and, to date, there have been no undesirable sequelae.
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The concentration of immunoglobulin classes G, M and A (IgG, IgM and IgA) in the sera of 233 aborted and 201 non-aborted foetuses was measured. IgM was first detected in a foetus at day 90 of gestation while IgG and IgA were first detected on day 111 of gestation. Immunoglobulins were detected in 81.5% of aborted foetuses and 32.8% of non-aborted foetuses. Total immunoglobulin concentrations of 20 mg/100 ml or greater were found in 35.2% of aborted foetuses but only in 4.5% of non-aborted foetuses. It is suggested that factors resulting in antigenic stimulation of the foetus may play an important part in bovine abortion.
Examination of catalase-positive Campylobacter-like organisms from cattle and pig abortions, indicated the existence of two distinct biochemical groups. The group 1 strains, predominantly of intestinal origin, were identified as C fetus subspecies intestinalis whereas the group 2 strains appeared similar but not identical to C fetus subspecies venerealis. This second group of organisms was recovered from fetal and placental tissue of animals which aborted, however, the majority of strains were isolated only at 30 degrees C in media not generally employed for Campylobacter isolation. All of the strains from group 2 became aerotolerant on subculture.
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An outbreak of mastitis involving approximately 70 out of 140 cows over a two-month period is described. Common mastitis pathogens were not incriminated. Leptospires belonging to the Hebdomadis serogroup were isolated from the milk of three out of five cows and the blood of two of those cows.
During the months October-May inclusive 90-8% of horses slaughtered at an abattoir near Dublin and 66-9% of those at an abattoir near Belfast were infected with Gasterophilus intestinalis; 28-6% of horses at the former abattoir harboured G nasalis while none of the horses examined at the latter abattoir was found to be infected with this species.
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A comparison was made of the sensitivity of two methods in current use for the detection of antibiotic residues in slaughter animals. Calves previously given therapeutic injections of an antibiotic were used and a variety of samples were tested.
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Groups of calves were injected with penicillin, ampicillin or oxytetracycline and a variety of samples were taken from the calves when slaughtered and tested for the presence of antibiotic residues by microbiological assay. Diaphragm and urine samples were found to be suitable for measuring detectable levels of antibiotics in calves given therapeutic injections.
When framycetin sulphate was fed at prophylactic levels to pigs, resistance to this antibiotic was induced within days in the enteric E coli. The E coli of the gut did not become fully susceptible again until six to seven weeks after the anitbiotic was withdrawn from the diet.