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Biomedical subjects

J J Misiewicz

Publications and source records attributed to J J Misiewicz.

At least 145 records · Page 8Linked to original sources
PubMed1974

Laxative-induced diarrhoea: a continuing clinical problem.

Seven women spent an average of 127 days in hospital and were extensively investigated, including a laparotomy, before their complaints of abdominal pain, diarrhoea, and weight loss were shown to be due to excessive taking of laxatives. All denied taking laxatives and in none were the characteristic features of the effects of cathartics on the colon seen on sigmoidoscopy or radiological examination.Hypokalaemia and other electrolyte abnormalities were common and were thought to be due to a combination of severe diarrhoea and vomiting. The rectal mucosa was seen to be abnormal on biopsy only in the three patients who had taken senna preparations. The diagnosis was not easy and was finally established either by analysis of the urine and stools or by searching the patient's ward locker.

Abdomen↗
PubMed1973

Action of oral metoclopramide on the gastrooesophageal junction in man.

The effect of oral metoclopramide, 10 mg, was studied with intraluminal manometry in 20 patients suffering from symptoms of gastrooesophageal reflux. The drug increased cardiac sphincter pressure and the amplitude of oesophageal peristaltic waves, but gastric motility was stimulated in only half of the patients. The clinical value of these pharmacological effects should be confirmed in therapeutic trials.

Administration, Oral↗
PubMed1972

Effect of eating on motility of the pelvic colon in constipation or diarrhoea.

Pelvic colonic pressures were recorded before, during, as well as after a meal in patients with non-specific diarrhoea (12) or constipation (14), who were selected according to strict clinical criteria of bowel habit. In the basal state diarrhoeal patients as a group had significantly less colonic activity than constipated patients, but the overlap was considerable. During the meal colonic activity was strikingly increased in diarrhoea, but returned to basal levels immediately after the meal; no such response was observed in constipation. It is suggested that this brief segmental response of the pelvic diarrhoeal colon may be inadequate to prevent entry of faeces into the rectum and the desire to defaecate, following a meal.

Adult↗