Hyperbaric oxygen therapy (HBOT) at 1, 2, and 2.75 atmospheres absolute (ATA) was used to treat rattlesnake (Crotalus atrox) venom-induced tissue damage and edema in thigh muscles of mice. Tissue damage was evaluated by double-blind histopathologic examination: tissue edema was determined by measuring tissue water content. A total of 10 intermittent exposures to oxygen over a period of 4 days at 2 and 2.75 ATA did not influence the resolution of venom-induced tissue edema, whereas tissue damage was significantly ameliorated as compared to air-treated envenomated controls. HBOT also promoted healing in the venom-injected mice as evidenced by the presence of regenerating muscle cells. It is concluded that HBOT may limit rattlesnake venom-induced myonecrosis and promote healing in a dose-response relationship without reducing venom-induced edema.

Animals↗

PubMedDate not supplied

Use of multiple views in the echocardiographic assessment of pulmonary artery systolic pressure.

The purpose of this study was to determine which echocardiographic views most reliably demonstrate the maximum velocity of a tricuspid regurgitant jet in the evaluation of pulmonary artery systolic pressure. Consecutive patients seen in three echocardiographic laboratories during a 3-month period were enrolled. A complete Doppler examination was performed on each patient, including a continuous-wave Doppler evaluation of tricuspid regurgitation in each of seven views. All seven views were used to determine the maximum velocity of tricuspid regurgitation. Of the 1163 studies, 866 (75%) had some tricuspid regurgitation by color-flow Doppler and 614 (53%) had a measurable velocity of tricuspid regurgitation in at least one view. No single echocardiographic view consistently yielded the maximum velocity of tricuspid regurgitation. The apical four-chamber view alone was inadequate. All seven views must be used to be certain that the maximum velocity of tricuspid regurgitation has been obtained.

Aged↗

PubMedDate not supplied

Pap prevalence and cervical cancer prevention among Alaska Native women.

The goals of the Alaska Native Women's Health Project (WHP) were to determine the following: (1) Pap prevalence based on chart review before and during an intervention period; (2) the level of understanding of cancer and cancer screening services with emphasis on cervical cancer; (3) use and satisfaction with current health maintenance services; and (4) improvement in knowledge and cancer screening rates following intervention. A random sample of 481 Alaska Native (Eskimo, Aleut, Indian) women living in Anchorage were interviewed face to face about their understanding of cancer risk factors (tobacco use, sexually transmitted diseases (STDs), reproductive issues), cancer screening examinations (Pap test, breast self-examination (BSE), breast exam by a provider, mammography), and their attitudes about health care and health care services. Sixty-two percent of control women were documented to have had at least one Pap test within the 3-year period prior to the beginning of the study; however, only 9% were documented to have had annual Pap screening. The intervention included distribution of educational materials, counseling on any woman's health issue, special evening clinics, and reminders (mail/phone call) of scheduled Pap appointments.

Adult↗

PubMedDate not supplied

Imaging epicardial oxygen.

Measurements of oxygen concentration and metabolic status in the heart are important to understanding the mechanisms that control cardiac respiration and its response to changing workload and substrate delivery. This paper presents images, recorded from a perfused rat heart, that reveal regional changes in concentrations of epicardial oxygen and of mitochondrial NADH in response to local ischemia, heterogeneous perfusion, and barbiturate inhibition. A fluorescence/ phosphorescence imaging system was developed to acquire digital images of oxygen concentration and NADH fluorescence from the epicardium of perfused hearts. The oxygen imaging technique is based upon quenching of Pd(II) meso-tetra(p-sulfonatophenyl)porphin phosphorescence by dissolved oxygen. Images of oxygen and NADH fluorescence provided complimentary information about oxygen supply and demand in the heart. The utility of two-dimensional measurements of the mitochondrial bioenergetic status is illustrated by the comparison of gradients for NADH and oxygen across the boundary separating locally ischemic tissue from normoxic epicardium. Images of oxygen concentration provide a powerful means for studying the dynamics of regional oxygen supply/ demand relationships in cardiac muscle.

Animals↗

PubMedDate not supplied

Glucocorticoids and hypertension in man.

Abnormalities of cortisol production or metabolism are involved in the genesis of hypertension in Cushing's syndrome, apparent mineralocorticoid excess and liquorice abuse and possibly in chronic renal failure and essential hypertension. We have studied the physiological mechanisms by which cortisol raises blood pressure in short term studies of cortisol administration in normal men. Cortisol induced hypertension cannot be explained by increases in vasopressor or decreases in vasodepressor hormone concentrations, or by any increase in sympathetic nervous activity. The hypertension is accompanied by substantial sodium retention but a significant component of the blood pressure rise is sodium independent. The hypertension is characterized by an increase in cardiac output but a rise in output is not essential for the rise in blood pressure. Our working hypothesis is that cortisol induced hypertension is a consequence of increases in renal vascular resistance.

Adult↗

PubMedDate not supplied

Cancer incidence in Alaska Natives thirty-year report 1969-1998.

The Alaska Native Tumor Registry includes data from 1969 to the present. This report provides incidence rates over the thirty year period, 1969 through 1998, and compares trends over time for Alaska Natives (AN) with those of US Whites and Blacks. To examine current rates, average annual age-adjusted incidence rates for AN for 1984-98 are compared with US Whites. Data from the registry document numerous differences in rates of occurrence of specific cancers compared to US Whites and Blacks. Studies of these differences may provide clues to the causes and risk factors for the cancers. Most importantly, these data show that although cancer was considered a rare disease in the Alaska Native population as recently as the mid-twentieth century, the incidence rate for all cancers combined among Alaska Natives is now as high as that of US Whites, and even higher in women. On the other hand, despite relative differences in rates, the most frequently diagnosed cancers among Alaska Natives are the same as US Whites. Cancers of the lung, colon/rectum, breast, and prostate are most frequently diagnosed among Alaska Natives and in the U.S. These four cancers comprise over 50% of all diagnosed invasive cancers. Cancer of the lung is almost entirely preventable by eradication of tobacco use. Screening and early detection have been proven to reduce mortality for cancers of the colon/rectum and breast. Primary and secondary prevention of these cancers could markedly improve morbidity and mortality.

Black or African American↗