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Biomedical subjects

J J Jones

Publications and source records attributed to J J Jones.

At least 73 records · Page 4Linked to original sources

Diabetes and its vascular complications in Malaysia.

One hundred and thirty-two newly diagnosed Asian diabetic patients (39 Malay, 30 Chinese and 63 Indians) have been studied in Kuala Lumpur. The highest proportion of diabetic patients were Indian and the lowest were Chinese. Vascular complications were equally common in Asian diabetic patients as in Europeans; coronary heart disease was relatively more common in Indians and cerebral vascular disease in Chinese. Twenty percent of all Asian diabetic patients requiring admission to hospital also had coronary heart disease, 9% had cerebral vascular disease and 8% had gangrene or ulceration of the feet. In Kuala Lumpur, diabetes is a very important risk factor for coronary heart disease: 17% of all patients admitted to the General Hospital with coronary heart disease were already diabetic.

Adult↗

The effect of protein energy malnutrition on plasma renin and oedema in the pig.

Five litter-mate male pigs, aged 7 days and fed a standard Pig Industry Board diet containing 190 g/kg dry mass of digestible protein, were compared with 10 male pigs from two litters fed a protein-deficient diet (50 g/kg) for a period of 70 days. The 10 experimental animals developed oedema between the 42nd and 70th days of the study and 4 of them became lethargic. Although the 10 experimental animals showed the typical biochemical changes characteristic of protein energy malnutrition (PEM), including changes in muscle electrolytes, liver fat and plasma albumin, the 4 lethargic animals showed a significant increase in effective plasma renin activity (EPRA) only by the 70th day of the study. Since oedema preceded any increase in EPRA in some pigs and developed in others without any change in EPRA, it is suggested that the increased renin activity is not responsible for the initial fluid retention and oedema.

Animals↗

Measuring emotional stress in Africa: the difficulties involved and some results.

Two surveys of emotional stress were undertaken and the difficulties experienced in each survey are discussed. In the first survey, 3 sets of personality inventories, selected to identify the type A personality that is associated with the early onset of coronary heart disease, were completed by 95 men, aged from 40 to 50 years, who came from 4 groups: White Rhodesians, urban Blacks of high and low social status, and Blacks from a rural area. The same trend was shown by all 3 inventories, which indicates that type A behaviour is least common among Whites, becomes progressively more marked in Blacks of upper social class, then in Blacks of lower social status, and is greatest in Blacks living in a rural environment. The psychogalvanic response to emotional stress (fear) was used to assess autonomic lability in the first 3 groups.

Adult↗

Plasma renin activity, water excretion and the decay of injected hormones and hormonal effects in rats with protein energy malnutrition.

Plasma renin activity was found to be correlated positively with muscle water content and the presence of oedema in rats with protein energy malnutrition, whereas the muscle potassium content showed a negative correlation with muscle water content. Malnourished rats also showed an inability to dispose of a water load. Nevertheless, the ability of malnourished rats to excrete injected hormones and to clear the plasma of bromosulphthalein proved to be normal. It is therefore concluded that, although the inability to balance consumption and excretion of water may in part be the result of increased effective plasma renin activity, the increased plasma concentration results from increased secretion rather than from decreased inactivation.

Aldosterone↗

Plasma renin activity in oedematous and marasmic children with protein energy malnutrition.

Plasma renin activity was measured by bio-assay in 52 children with kwashiorkor, in 28 with marasmus and in 21 healthy children. Plasma renin activity was significantly increased in children with kwashiorkor and marasmus, compared with healthy children, and in children who died, compared with survivors. No strict causal relationship could be found between plasma renin activity and the degree of oedema in kwashiorkor. Increased renin activity probably results from a terminal change in cardiovascular function.

Blood Proteins↗

Cortisol and growth hormone in kwashiorkor and marasmus.

Cortisol and growth hormone concentrations in the plasma were determined in 26 children with kwashiorkor, 13 with marasmus, and 21 controls. Cortisol levels were high in babies with kwashiorkor and marasmus, but higher in the former, in relation to a constant body mass. The concentration of plasma cortisol correlated positively with the body mass deficit in kwashiorkor (r = 0,66) and in children with low mass for age (r = 0,75). Growth hormone levels were elevated in both kwashiorkor and marasmus. The proposed role of these hormones in metabolic adaptation to malnutrition is discussed.

Body Weight↗

A study of the perceptions of dental deans toward formal administrative training.

In order to understand better the attitudes of dental deans toward formal administrative training, a questionnaire was devised which asked for both personal and opinion data. Questionnaires were mailed to 209 persons with the title of "dean" at the 58 institutional members of the American Association of Dental Schools. Replies were received from 167 respondents (80%), and the replies were subdivided into the categories of dean, associate dean, and assistant dean, according to each respondent's stated position. Personal data on the questionnaire included the respondent's age, sex, and education, as well as information on his current position. Additional data on the questionnaire were concerned with the respondent's opinion on the value of formal administrative training for someone in his position, and what specific areas of training would be most valuable. In addition, the respondents were asked to rank formal training against other methods of gaining experience and to make appropriate comments. The majority of respondents felt that formal administrative training would be of value and that such factors as decision-making and leadership behavior training would be very valuable. The respondents felt that formal administrative and teaching experience would be even more helpful.

Adult↗