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Biomedical subjects

J J Gillespie

Publications and source records attributed to J J Gillespie.

22 records · Page 2Linked to original sources

Betting on the future: the virtues of contingent contracts.

It happens all the time. Two parties with common interests fail to reach an agreement--about a sale, a merger, a technology transfer--because they have different expectations about the future. They are both so confident in their prediction, or so suspicious of the other side's motives, that they refuse to compromise. Such impasses are hard to break through. Fortunately, they can often be avoided altogether by using a straightforward but frequently overlooked type of agreement called a contingent contract. The terms of a contingent contract are not finalized until the uncertain event in question--the contingency--takes place. In some areas of business, such as compensation, contingent contracts are common: a CEO's pay is tied to the company's stock price, for instance. But in many business negotiations, contingent contracts are either ignored or rejected out of hand. That's mistake, according to the authors. In an increasingly uncertain world, flexible contingent contracts can actually be more rational and less risky than rigid, traditional ones. In particular, contingent contracts offer six benefits: they enable a difference of opinion to become the basis of an agreement, not an obstacle to it; they cancel out the biases of negotiators; they level the playing field by reducing the impact of asymmetric information; they provide a means of uncovering deceitful dealings; they reduce risk by sharing it among parties; and they motivate parties to fulfill their promises. While contingent contracts are not appropriate in all instances, they are much more broadly applicable than managers may think.

Contract Services↗

Fine needle aspiration diagnosis of a nasopharyngeal teratoma.

A newborn presented with airway obstruction due to a large nasopharyngeal mass extending into the oropharynx. A diagnosis of teratoma was made by transoral fine needle aspiration (FNA) biopsy and confirmed by subsequent histologic studies. The cytologic features of nasopharyngeal teratoma are presented, and the diagnostic utility of FNA biopsy in evaluating such lesions is discussed.

Biopsy, Needle↗

Ultrastructural diagnosis of large cell 'undifferentiated' neoplasia.

Large cell undifferentiated neoplasia' provides a generic designation for a heterogeneous group of neoplasms which by histological study, are devoid of discriminate architecture and appear under the light microscope as patternless sheets of large cytoplasmic cells. The interpretation of such a tumour will routinely present significant problems in differential diagnosis. By conventional light microscopy the neoplasm may subjectively be judged to represent a certain form of carcinoma or large cell lymphoma, but often identification is relegated to a label of "consistent with', or "undifferentiated malignant neoplasm'. Such interpretations are not acceptable and preclude rational management decisions. This paper has analysed tumour cell ultrastructure derived from a spectrum of clinicopathological situations involving the diagnostic problem of the large cell undifferentiated neoplasm. The fine structural morphologies of these enigmatic tumours are often sufficiently specific to allow resolution of the differential diagnosis and assignment of cell type. Diagnostic electron microscopy, in coordination with histopathology and clinical information, will often play a significant role in solving complex problems involving the differential diagnosis of large cell undifferentiated neoplasms.

Adolescent↗