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Biomedical subjects

J J Furedy

Publications and source records attributed to J J Furedy.

At least 73 records · Page 4Linked to original sources

Heart-rate decelerative Pavlovian conditioning with tilt as UCS: towards behavioural control of cardiac dysfunction.

As part of a programme the ultimate goal of which is to teach behavioural control of stress-induced maladaptive cardiac accelerations through Pavlovian decelerative conditioning, this study was directed at examining the feasibility of using tilting of the body from a head-up to a head-down position as the unconditional stimulus (UCS) to elicit phasic cardiac deceleration as the unconditional response (UCR). Experiment I assessed the reflexive features of the cardiac response to 32 tilt UCS trials delivered at mean intervals of 75 sec. The results yielded a large-magnitude (over 30 BsPM) cardiac decelerative UCR with fast recruitment and complete resistance to habituation. Experiment II examined the feasibility of using the tilt UCS to demonstrate associative control over decelerative responding to a tone as the conditional stimulus (CS). Relative to a control 'backward' UCS-CS group with an interstimulus interval (ISI) of 14.5 sec, a 0.5 sec ISI CS-UCS experimental group demonstrated both orderly acquisition and extinction performance. The magnitude of the conditional deceleration of some 4 BsPM is greater than the extent of control generally achieved with biofeedback, but still constitutes a problem for theoretical accounts of classical conditioning framed in terms of stimulus substitution, and is still only of borderline clinical significance.

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Test of an orienting-reaction-recovery account of short-interval autonomic conditioning.

The electrodermal and plethysmographic components of the orienting reaction in 24 subjects were examined in a conditioning-analog arrangement (tones and lights patterned analogously to CS and UCS presentations in classical conditioning) in order to test the orienting-reaction-recovery (ORR) account according to which apparent short-interval autonomic conditioning (SIAC) can be completely accounted for by an ORR effect. The form of the test was to see whether ORR following change from a repeatedly presented forward ('CS-UCS') analog would exceed that to change from a backward ('UCS-CS') analog, as is the case in SIAC with CS-alone test trials following repeated CS-UCS versus UCS-CS pairings. The results did not support the ORR account, although they were shown to be consistent with the relevant experimental literature, when critically examined, and to provide internal evidence for the adequacy of the present test of this particular formulation of the ORR account of SIAC.

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Human Pavlovian decelerative cardiac conditioning based on a respiratory-induced cardiac deceleration as an unconditional reflex.

This study was directed at examining the feasibility of using a respiratory-induced cardiac decelerative reflex as an unconditioned response (UCR) in a Pavlovian conditioning paradigm. Experiment I assessed the reflexive features of the cardiac response under a respiratory procedure which involved 3 sec of exhalation, 4 sec of inhalation, and then 30 sec of breath-holding (BH). The results indicated that the BH onset aspect of this respiratory cycle involved a phasic, large-magnitude cardiac deceleration (27 beats/min) with short latency, fast recruitment, and no indication of habituation over trials. Experiment II examined the feasibility of using BH onset as an unconditioned stimulus (UCS) in a Pavlovian paradigm by presenting an auditory conditional stimulus (CS) 1 sec prior to the instructed BH aspect of the respiratory cycle. A separate control condition involved presenting the CS 10 sec after BH onset which constituted a 'backward' conditioning control. The results indicated that the conditioning group displayed a significant cardiac deceleration on CS-alone test trials (under normal breathing) in contrast to the absence of such an effect for the control group. In brief, the study suggested that a decelerative conditioned response (CR) could be established by using a respiratory-induced cardiac deceleration as a Pavlovian UCS. Potential clinical applications of such a decelerative CR were noted.

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