Search PubMed⌕ Search

Biomedical subjects

J J Cream

Publications and source records attributed to J J Cream.

At least 55 records · Page 3Linked to original sources
PubMed1980

The effect of methotrexate and hydroxyurea on neutrophil chemotaxis.

Methotrexate depresses motility of neutrophils in chamber membranes, but does not interfere with random motility in tubes. Hydroxyurea has no such effect. The therapeutic response to methotrexate in psoriasis may be due in part to a reduction in migration of neutrophils into the epidermis.

Cell Movement↗
PubMed1979

Cutaneous arteritis with superior vena cava obstruction.

Superior vena cava (SVC) obstruction may occur in several disorders (Urschel & Paulson, 1966) and may be associated with arteritis in Behçet's disease (Chajek & Farinaru, 1975). We report a man who had arteritis and SVC obstruction without any of the known causes.

Adult↗
PubMed1979

Complement abnormalities in diffuse plane xanthomatosis with paraproteinaemia.

Paraproteinaemia may be associated with xanthomatous skin deposits and these can arise in the absence of elevated lipid levels. Two cases of benign monoclonal gammopathy with diffuse plane xanthomatosis are reported. Case 1 exhibited hypolipidaemia and a functional deficiency of C1 esterase inhibitor. Case 2 showed a normal lipoprotein profile, abnormal platelet aggregation, and a cutaneous vasculitis with evidence of complement consumption via the classical pathway. The significance of these abnormalities is discussed.

Aged↗
PubMed1979

Genetic basis of acquired C4 deficiency.

A study of the family of a patient who had an SLE-like syndrome and an extremely low serum C4 revealed an inheritance of C4 types and HLA region markers which indicated that the patient had 60--70% of "normal" C4 level prior to the onset of disease. Thus the extremely low C4 level during her disease may result from a combination of genetically determined low normal C4 and increased consumption/hyposynthesis secondary to her SLE.

Adult↗
PubMed1976

Clinical and immunological aspects of cutaneous vasculitis.

Thirty-five patients with cutaneous vasculitis were studied. Sixteen had raised serum levels of cryoglobulins. In all but one the cryoglobulin was an immune complex. Eleven patients had anticomplementary sera and five had a low serum IgM. Clinically, the cryoglobulinaemic patients were not readily distinguishable from the non-cryoglobulinaemic in that cold sensitivity occurred in only six of sixteen patients with cryoglobulins. Peripheral neuropathy and lesions in the upper respiratory tract were confined to those with cryoglobulinaemia. An immunopathological classification for the purpuric vasculitides is suggested.

Adult↗
PubMed1972

Cryoglobulins.

Explore the source record for details and available documents.

Antibodies, Anti-Idiotypic↗