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Biomedical subjects

J J Chang

Publications and source records attributed to J J Chang.

9 recordsLinked to original sources
PubMed1992

The effects on lipid metabolism of 4-phenyl-5,5-dicarbethoxy-2-pyrrolidenone in Sprague Dawley rats.

4-Phenyl-5,5-dicarbethoxy-2-pyrrolidenone [XIV] treatment in Sprague Dawley rats caused significant reduction of serum cholesterol and triglyceride levels with reduction of VLDL and LDL cholesterol levels. The compound significantly reduced regulatory enzyme activities, e.g. ATP dependent citrate lyase, HMG CoA reductase, acyl CoA cholesterol acyl transferase, cholesterol-7-alpha-hydroxylase, sn-glycerol-3-phosphate acyl transferase and phosphatidylate phosphohydrolase. In tissue cultured cells, the compound suppressed LDL receptor activity and degradation, and elevated HDL receptor activity and HDL degradation. Rat bile cholesterol and phospholipids were elevated; however, overall bile acids were reduced. In situ loop studies suggest that the agent interfered with interhepatic reabsorption of cholesterol and cholic acids. At the therapeutic dose of compound XIV, no deleterious effects were demonstrated in mice.

Animals↗
PubMed1979

Symmetry perception and spatial-frequency channels.

It is known that the sum of a random-dot array with vertical bilateral symmetry and one with horizontal bilateral symmetry appears as a random array. Here we show that if the vertically and horizontally symmetrical arrays are spatially filtered, so that their respective spectra are 2 octaves apart, then their superposition does not appear random, but both symmetries can be simultaneously perceived. The low-band array has a stronger perceptual weight than the high-band array. These demonstrations give further evidence that frequency channels are before symmetry perception.

Depth Perception↗
PubMed1978

Feeding motor program in Limax. I. Neuromuscular correlates and control by chemosensory input.

The feeding motor program(FMP) of the terrestrial slug Limax maximus was examined in vivo and in vitro. The feeding pattern of intact animals shows an initial increase in bite frequency followed by a plateau phase. Recordings obtained from semi-intact preparations of the lips, brain, and buccal mass established the correlation of activity in buccal ganglion nerve roots with the protraction-retraction bite cycle. A preparation of the lips, cerebral ganglia, and buccal ganglia was developed, such that, repetitive chemostimulation of the lips yields reproducible bouts of FMP. Sources of proprioceptive feedback from buccal muscles were demonstrated. The feasibility of computer scoring of the FMP is documented. The results demonstrate that aspects of in vivo feeding behavior are retained and identifiable in highly dissected, in vivo preparations.

Animals↗
PubMed1978

Inversion of articulatory-to-acoustic transformation in the vocal tract by a computer-sorting technique.

We present numerical methods for studying the relationship between the shape of the vocal tract and its acoustic output. For a stationary vocal tract, the articulatory-acoustic relationship can be represented as a multidimensional function of a multidimensional argument: y=f(x), where x, y are vectors describing the vocal-tract shape and the resulting acoustic output, respectively. Assuming that y may be computed for any x, we develop a procedure for inverting f(x). Inversion by computer sorting consists of computing y for many values of x and sorting the resulting (y,x) pairs into a convenient order according to y; x for a given y is then obtained by looking up y in the sorted data. Application of this method for determining parameters of an articulatory model corresponding to a given set of formant frequencies is presented. A method is also described for finding articulatory regions (fibers) which map into a single point in the acoustic space. The local nature of f(x) is determined by linearization in a small neighborhood. Larger regions are explored by extending the linear neighborhoods in small steps. This method was applied for the study of compensatory articulation. Sounds produced by various articulations along a fiber were synthesized and were compared by informal listening tests. These tests show that, in many cases of interest, a given sound could be produced by many different vocal-tract shapes.

Acoustics↗