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Biomedical subjects

J J Bernier

Publications and source records attributed to J J Bernier.

At least 73 records · Page 4Linked to original sources
PubMed1981

Intestinal clearance of alpha 1-antitrypsin. A sensitive method for the detection of protein-losing enteropathy.

Gastrointestinal loss of plasma is usually measured with radiolabeled macromolecules. These methods are expensive and cumbersome. The use of alpha 1-antitrypsin as an endogenous marker and the determination of alpha 1-antitrypsin fecal clearance enable the diagnosis of protein-losing enteropathy. alpha 1-Antitrypsin is measured in feces and blood by radial immunodiffusion, and the results are expressed as clearance. There is a significant correlation between alpha 1-antitrypsin fecal clearance and 51Cr-plasma protein clearance (r = 0.96, p less than 0.001). The sensibility of alpha 1-antitrypsin test compared to [51Cr] is 93.3%, the specificity is 90%. The positive predictive value is 97.7%, the negative predictive value 75%. We found no alpha 1-antitrypsin in gastric juice of pH below 3. In vitro studies confirmed the destruction of alpha 1-antitrypsin in gastric juice of pH below 3. There is a slight decrease of alpha 1-antitrypsin concentration when stools are incubated at 37 degrees C. In duodenal juice there is a small lessening of alpha 1-antitrypsin concentration after an incubation at 37 degrees C for 1 h. In conclusion, the fecal clearance of alpha 1-antitrypsin seems to be an inexpensive and quite reliable test of protein-losing enteropathy.

Humans↗
PubMed1981

A cooperative study on the detection of colorectal cancer and polyps in France.

Systematic investigations testing for the presence of polyps and cancers of the large bowel were conducted in a population of 1,369 inpatients and outpatients, aged 45-70 years, in eight university departments of gastroenterology or abdominal surgery (Toulouse, Dijon, Paris, Marseille, and Strasbourg). Double-contrast barium enema and proctosigmoidoscopy examinations were carried out in all cases, whereas total coloscopy was performed only in the case of detected tumors. A questionnaire including 233 parameters (age, sex, family, and personal history and symptoms) was completed for each patient. A total of 414 lesions were detected in 252 patients, including 245 adenomatous or villous polyps, 8 transformed polyps, and 30 carcinomas; 3 of 4 lesions were located in the rectum or sigmoid. Cancer or adenomatous or villous polyps were found in 13% of the patients. The prevalence of these lesions in the population studied was increased in patients with rectorrhagia (19%) or with a personal history of surgery for colorectal cancer or polyp (23%). In the patients without rectorrhagia or a history of intestinal tumor, the incidence was 9.7%. It was significantly increased in males and patients more than 50 year old. The efficacy of proctosigmoidoscopy and double-contrast barium enema was compared in 909 patients. Sensitivity and specificity were, respectively, 35% and 99% for endoscopy, 96% and 94% for radiology.

Aged↗
PubMed1980

[Intestinal clearance of alpha 1 anti-trypsin: a simple technique for diagnosis of protein losing enteropathy (author's transl)].

Until recently, to diagnose exsudative enteropathy required the use of radio-isotopes and a stay of several days in hospital. Alpha-1-antitrypsin can now be used as endogenous plasma marker and assayed in the serum and faeces by a simple immunochemical method, thus measuring its intestinal clearance. Fifteen healthy subjects and 13 patients with organic digestive diseases were investigated by this method. The mean clearance values were inferior to 10 ml/24 h in the control group and significantly higher in the patients' group. Digestive protein loss can therefore be diagnosed by the new method, which offers the additional advantages of being reliable, easy, relatively inexpensive and applicable to out-patients.

Clinical Enzyme Tests↗
PubMed1980

Effect of a combination of gastrin, secretin, cholecystokinin, glucagon, and gastric inhibitory polypeptide on jejunal absorption in man.

In 11 conscious volunteers, the jejunal absorption was measured during basal state and during the simultaneous intravenous infusion of small doses of gastrin, secretin, cholecystokinin, glucagon and gastric inhibitory polypeptide. The blood levels of gastrin, secretin, glucagon, and GIP were measured by RIA and were close to those achieved after a meal. The basal net absorption of water and electrolytes was reversed to a net secretion during the hormonal infusion. These results suggest that the jejunal secretion observed after a meal in man may be mediated by hormones released by the meal.

Adolescent↗
PubMed1980

[Effect of colonic distension on exocrine pancreatic secretion of the conscious rat].

In the conscious rat the increasing distension of the colon (from 2 to 6 ml) induced a slight decrease of exocrine pancreatic secretion which was more important for protein output than for volume. Nevertheless this inhibitory effect was never significant even with the important distension of 6 ml which induced a visible uneasiness in the animal.

Animals↗
PubMed1979

[II. Etiological classification of the small bowel diseases (author's transl)].

A new classification of the small bowel diseases is proposed according to - the physiopathology; - the anatomo-pathology; - the etiology. In this second part, the ethiological classification is developed. One may distinguish the post-surgical lesions, congenital defects, the side-effects of drugs and the vascular lesions. Allergy and infection are especially studied. The main problems which may be solved in a next future are: the mechanism of chronic infections, the biochemical pathology and especially the normal and pathological immunology.

Blind Loop Syndrome↗
PubMed1979

[Physiopathological and anatomical classification of small bowel diseases (author's transl)].

The first small bowel diseases have been known for three centuries, but essential breakthroughs have occured in the last twenty years. A new classification may be proposed according to, the physiopathology, the anatomo-pathology, the etiology. From the physiopathological point of view one may separate enterocytic, pre-enterocytic or post-enterocytic malabsorptions. Small bowel injuries described by the pathologist include small bowel resections, villous atrophy, lesion of the lamina propria, or transmural lesions, the vascular pathology and the ulceration of the small bowel. A new syndrome is proposed: the rupture of the cellular continuity or intercellular syndrome.

Atrophy↗