Biomedical subjects

J J Barboriak

Publications and source records attributed to J J Barboriak.

At least 109 records · Page 6Linked to original sources

PubMed1976

Changes in occupation after aortocoronary vein-bypass operation.

The effect of aortocoronary vein-bypass operation on changes in occupational status was investigated in a cohort of 893 men. The median period of time between the operation and follow-up evaluation of postoperative occupational status was 14 months. The patients were divided into two age groups, with 55 years as the dividing point. The results showed that 11% of the younger men and 26% of the older group who were employed before the operation retired following the operation. In addition, 30% of the patients changed their occupational status following the operation. When occupational changes also resulted in changes in physical demands, 49% of the patients took new jobs that were less demanding physically, while 40% took jobs that were more demanding. Close to 9% of the patients were retired prior to the operation; about one fifth of them came out of retirement following the operation.

Adult↗

PubMed1976

Metabolic changes in exercise-induced and methacholine-induced bronchoconstriction.

Metabolic and physiological responses to graded exercise and methacholine challenge were investigated in asthmatics with or without exercise-induced bronchoconstriction. The results showed that after methacholine challenge, free fatty acid levels increased only in patients with exercise-induced asthma, while they increased in both groups of asthmatics after treadmill exercise. No significant changes were noted in plasma lactic acid levels, ventilation, or oxygen consumption among the groups studied. These data suggest that asthmatics with exercise-induced bronchoconstriction may differ from other asthmatics in some of their metabolic responses.

Adolescent↗

PubMed1976

Immunologic cross-reactions among thermophilic actinomycetes associated with hypersensitivity pneumonitis.

Antibodies produced in rabbits against Micropolyspora faeni, Thermoactinomyces vulgaris, T. sacchari, Thermoactinomyces candidus, and Saccharomonospora viridis were tested against antigens derived from many strains of thermophilic actinomycetes for precipitating antibodies by immunodiffusion test. It was found that immune sera reacted strongly against antigens from strains belonging to the same species and weakly against antigens from different species of thermophilic actinomycetes. However, sera from farmer's lung patients showed cross-reactivity against antigens from different species. This may be because the patient is sensitized to multiple species of thermophilic actinomycetes present in the environment and developed antibodies against most of them.

Animals↗

PubMed1976

Pathological changes in surgically removed aortocoronary vein grafts.

Pathological changes in aortocoronary vein grafts were investigated in 17 patients who had a second revascularization procedure 1 to 53 1/2 months after their initial operation. Subendothelial proliferation was present in all grafts and had resulted in total occlusion of 7. With increasing duration of implantation the proliferative lesions tended to show hyalinization and to affect the media. Advanced atherosclerosis had developed in 2 grafts.

Adult↗

PubMed1976

Heart disease indicators in patients with aortocoronary bypass operation.

The incidence of cardiovascular disease risk factors and other indicators of cardiac impairment were studied in 478 patients prior to their aortocoronary vein bypass operation and 194 patients who had angiographic examination but did not undergo the operation because the clinical and coronary angiographic findings were not considered serious enough to warrant the bypass procedure. The patients referred for surgery had higher plasma cholesterol and triglyceride levels (259 and 219 vs 233 and 180 mg/100 ml), tended to be older (53 vs 49 years) and had more extensive occlusive disease (occlusion score 200 vs 70) than the group without the operation. There was little difference in the proportion of smokers (81 vs 83%) or prevalence of hypertension (33 vs 30%). In comparison with 9,964 participants of a local health screening program, both patient groups had markedly higher prevalence of smoking, hypertension, chest pain and previous myocardial infarcts.

Cholesterol↗

PubMed1976

Interstital lung disease due to contamination of forced air systems.

Eight patients had hypersensitivity pneumonitis due to contaminated home or office forced-air heating or air-conditioning systems. We studied their clinical and laboratory features, and the results indicated that this disease may occur as an acute or insidious form differing in type and intensity of respiratory and systemic symptoms. Thermophilic actinomycetes contaminatinf the forced air systems were identified as the sensitizing agents in most cases. Precipitating antibodies to the organisms could be shown in the serums of the patients and the antigen identified by immunofluorescent studies in the three lung biopsies examined by this method. Inhalation challenge studies with the cultured organism or other materials obtained from the forced air systems reproduced the clinical syndrome in the four patients tested. Avoidance of the contaminated system, and the use of corticosteroids in more severe cases,seems to be appropriate therapy for patients with this disease.

Actinomycetales↗

PubMed1976

Scanning electron microscope study of human veins and aorta-coronary artery vein grafts.

Scanning electron microscope study of two vein grafts which were removed after 50 months of implantation as aorta-coronary artery vein grafts showed considerable subendothelial thickening, which consisted of relatively cell-poor fibrous layer. In one of the grafts the endothelial surface was intact; the second graft showed focal loss of endothelial cells. Sections of two fresh human veins, studied prior to their insertion as aorta-coronary artery vein grafts, have shown that they retained an intact endothelial layer. A third fresh vein, however, showed focal damage with missing endothelial cells and adherent fibrin.

Autopsy↗

PubMed1976

Preoperative risk factors and aorta-coronary bypass graft patency.

The relationship between graft patency and the presence of presurgical prognostic factors was studied in 636 patients who have undergone aorta-coronary bypass operation. We have found a positive correlation between vein graft patency and both coronary artery constriction score (p less than 0.01) and diastolic blood pressure (p less than 0.05). In patients studied up to one year after surgery, high graft patency was associated with both higher diastolic pressures (p less than 0.03) and higher cholesterol levels (p less than 0.001). However, high cholesterol levels also were associated with coronary arterial obstruction. In patients studied more than a year after operation, high constriction scores before the operation were associated with improved graft patency (p less than 0.03). Our findings indicate that short-term prognosis of the grafts is related mainly to hemodynamic variables.

Age Factors↗

PubMed1976

Animal model of sensitization by inhalation.

Groups of rats exposed to daily inhalation challenge with aerosolized pigeon serum developed precipitating antibody within 2 weeks and definitive granulomatous inflammatory changes in the lung after 7 weeks of exposure. The dissociation of the two responses to an inhalation challenge indicate that the rat model may serve for screening of the various inhalant antigens for their sensitizing potential, and for investigation of the contributory role of some of the factors involved in the pathogenesis of hypersensitivity pneumonitis.

Animals↗

PubMed1975

The Wisconsin Allergy Society fee and practice survey. A study for professional standard review organizations.

Physicians practicing allegy in the State of Wisconsin were surveyed regarding their fees charged and norms of practice relating to the diagnosis and management of patients with allergic diseases. Over 50% of the physicians surveyed responded and the results were compiled and analyzed. The data obtained provide an over-view of the practice of a medical subspecialty and can thus be used for possible peer evaluation.

Fees, Medical↗

PubMed1975

Cell-mediated hypersensitivity in pigeon breeders.

This investigation was carried out to study possible differences in cell-mediated hypersensitivity between symptomatic and asymptomatic pigeon breeders. A variety of pigeon antigens were investigated using the indirect migration inhibition test. Cell-mediated hypersensitivity to pigeon antigens was detected in 6 of 8 symptomatic pigeon breeders, and in only 2 of 12 asymptomatic pigeon breeders. The results suggest that cellular mechanisms may be important in the pathogenesis of pigeon breeder's disease.

Animals↗

PubMed1975

The effect of hypoglycemia on hypothalamic thyrotropin-releasing hormone (HRH) in the rat.

A rapid radioimmunoassay for TRH with a high degree of specificity and sensitivity is described. The procedure is capable of measuring TRH in amounts less than 15 pg/tube. Such an assay system has enabled us to study the effect of hypoglycemia on hypothalamic TRH content. Forty-eight female, adult Holtzman rats were divided into 8 groups of 6. Regular insulin was injected intraperitoneally into each rat except for the basal group. A separate batch of similar rats was studied in the same fashion except that saline was injected instead of insulin. Each group of rats was decapitated and the trunk blood collected at 0, 15, 30, 45, 60, 90, 120 and 180 min post-injection. Appropriate tissues were rapidly taken and immediately extracted in ice-cold methanol. Hypothalamic TRH, pituitary TSH, serum TSH and serum triiodothyronine (T3) and thyroxine (T4) were serially determined. In the insulin-treated group, a rapid fall in blood sugar was observed reaching a nadir in 15 min. Hypothalamic TRH fell from a basal mean +/- SE value of 3.25 +/- 0.31 ng to 1.54 +/- 0.14 ng/hypothalamus (P less than 0.01). Pituitary TSH decreased from 10.0 +/- 0.9 mug to a low of 2.6 +/- 0,8 mug/pituitary (P less than 0.02) at 30 min postinsulin. Serum TSH increased from a basal level of 42.5 +/- 20.5 muU/mo to a peak of 102.1 +/- 10.0 muU/ml 45 min (P less than 0.05) after insulin administration. The incremental change in serum T3 occurred at 90 min when T3 levels increased from a baseline of 107.5 +/- 53.7 ng/100 ml to a peak of 711.7 +/- 20.2 ng/100 ml (P less than 0.01). No changes in T4 were observed. The control group of rats did not show significant changes in hypothalamic TRH. The results of the study indicate that hypoglycemia can induce depletion (presumably release) of hypothalamic TRH with a consequent cascade stimulation of the pituitary-thyroid axis.

Animals↗

PubMed1974