Speech perception of Japanese language in patients using cochlear implants.
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Adolescent↗
Biomedical subjects
J Ito
Publications and source records attributed to J Ito.
Temporal bone pathology of a patient with cochlear implant.
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Aged↗
Sulochrin inhibits eosinophil degranulation.
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Anti-Allergic Agents↗
Large vestibular aqueduct syndrome with high CT density and high MR signal intensity.
We report a case of large vestibular aqueduct syndrome with a markedly dilated endolymphatic sac bilaterally. The density and signal intensity of the extraosseous portion of the sac were higher than those of cerebrospinal fluid on CT and MR studies. The findings may represent protein-rich and hyperosmolar fluid within the endolymphatic sac.
Adult↗
Neuroradiological assessment of visuoperceptual disturbance in children with spina bifida and hydrocephalus.
The intellectual status of twelve children with spina bifida and hydrocephalus was evaluated. Seven children were considered to have verbal and non-verbal skill discrepancies. It was considered that the Verbal IQ-Performance IQ score by WISC-R could be used as an index of their visuoperceptual disturbance. The disturbance was closely related to the morphological characteristics of the lateral ventricles on cerebral MRI. The ratio of the areas of the posterior horns to the anterior horns (P:A) showed a negative correlation with visuoperceptual ability. The visual pathway, visual cortex, and the ventral system were thus considered to be the sites of the affected lesions. From P:A changes with time, it was evident that adequate shunting would prevent the perceptual disturbance.
Adolescent↗
Kindling induces neuropsin mRNA in the mouse brain.
Neuropsin mRNA expression was analyzed and mapped in the mouse brains after kindling epileptogenesis by using in situ hybridization histochemistry. Dynamic increases of the neuropsin mRNA were observed in the layer II of prelimbic, somatosensory, auditory, perirhinal, entorhinal, and piriform cortices in an activity-dependent manner, though no neuropsin gene was expressed in these areas in control mice. In addition to the confirmation of our previous studies showing increases of mRNA in the hippocampus and amygdaloid complex, there were also remarkable increases of the neuropsin mRNA in the limbic areas, such as the accessory olfactory nucleus, the medial and lateral septal nucleus, the nucleus of diagonal band, the substantia innominata and the zona incerta. The dynamic activity-dependent changes of the gene expression and the site-specificity of neuropsin localization are suggesting that this molecule is implicated in cortical- and limbic-specific neuronal reorganization.
Animals↗
Cystic Hypersecretory Duct Carcinoma of the Breast:A Case Reprot Describing the Cytologic Features.
We report the clinical, cytological and pathological features of so-called cystic hypersecretory duct carcinoma occurring in a 60-year-old Japanese woman. The tumor mainfested a multicystic mass ultrasonographically, and aspiration biopsy cytology revealed atypical ductal epithelial cells with vacuolar cytoplasm. A modified radical mastectomy was performed. Histologically, the lesion was charcterized by many dilated ducts containing eosinophilic secretions, which resembled thyroid colloid. The ducts were lined by an intraductal micropapillary carcinoma with hobnail-shaped cells, and were positive for lactalbumin immunohistochemically. Additionally, a so-called cystic hypersecretory hyperplasia was seen in the surrounding breast parenchyma. Although a direct transition from the hyperplasia to the carcinoma was not proved, a close relationship between the two lesions was suggested.
Journal Article↗
Effects of fructose ingestion on sorbitol and fructose 3-phosphate contents of erythrocytes from healthy men.
To investigate the effect of fructose ingestion on sorbitol and fructose 3-phosphate (F3P) in erythrocytes, we administered 50 g fructose with and without treatment with an aldose reductase inhibitor, epalrestat, to seven healthy, normal-glucose-tolerant, male volunteers aged 20-43 years. The same subjects were given 50 g glucose on another day. The sorbitol and F3P contents in their erythrocytes increased significantly, reaching peak levels at 60 min and 180 min, respectively, following fructose in gestion. On the other hand, glucose ingestion did not cause any statistically significant change in sorbitol content in their erythrocytes, although it significantly elevated their F3P content. Treatment with epalrestat had no significant effect on incremental changes in erythrocyte sorbitol and F3P content following fructose ingestion. This suggests that oral fructose may be converted directly to sorbitol and F3P in erythrocytes instead of being converted via glucose. Thus, the dietary intake of fructose may affect the concentrations of sorbitol and F3P in erythrocytes in normal men.
Adult↗
Development of fat within a meningioma.
We report a tentorial meningioma containing fat. Multiple areas of fatty density or intensity in the tumour were seen on CT and MRI, which corresponded histologically to lipomatous components. CT 10 years previously had demonstrated a smaller tumour without evidence of fatty components. We found only five cases in the literature in which fatty density was demonstrated within a meningioma on CT and a lipomatous component histologically proved. Xanthomatous change, with lipid in tumour cells, causes decrease in density on CT, but not to the levels of fat. As both lipomatous components and xanthomatous change show similar intensity on MRI, CT can be helpful in differentiating these two conditions. To our knowledge, our case is the only one in which the advent of fatty tissue was confirmed during follow-up.
Adipose Tissue↗
Promotion of microfilament polymerization by depolymerized glia filament preparation through interaction of vimentin with actin.
We investigated the in vitro interaction between microfilaments and glia filaments in the presence of alpha-sialosylcholesterol (SC). The depolymerized glia filament preparation (GF) that had been extracted from a crude cytoskeletal fraction of cultured rat astrocytes promoted markedly the polymerization of the depolymerized microfilament preparation (MF) in the presence of SC. The ability of GF to promote the MF polymerization was highest in the concentration range 7.5-15 microM SC. The polymerization of MF at the concentration of 10 micrograms protein/200 microliters was enhanced to the highest level by 4 micrograms protein/200 microliters of GF in the presence of 15 microM SC. The MF polymerization was promoted more efficiently by GF than by MF: for example, the polymerization of actin in MF (7.5 micrograms/200 microliters) was enhanced by the addition of 5 micrograms GF protein/200 microliters to a twice greater extent than by the addition of 5 micrograms MF protein/200 microliters in the presence of 15 microM SC. GF enhanced the MF polymerization by over three-fold at 4-37 degrees C, and the GF activity became greater with an increase in incubation temperature. Vimentin promoted the G-actin polymerization in the presence of 11.3 microM alpha-SC. The finding suggested that the interaction between vimentin and actin was one of the factors to cause GF to promote the MF polymerization.
Actin Cytoskeleton↗
The prognosis and the treatment of patients with a C3/4 spinal cord injury.
Twenty patients with a C3/4 spinal cord injury have been treated in our hospital since 1974. There were 15 new patients. The average follow up period was 68 months, ranging from 7 to 162 months. The 15 new cases were classified as Frankel A in nine cases, B in one, and C in five. Frankel A or B were usually accompanied by either an unstable spinal fracture or by spinal canal stenosis at the C3/4 level. Twelve patients received surgery. At the most recent follow up, eight of the 15 patients (53.3%) had improved according to Frankel's classification. Five, all Frankel A on remission, have died between 2 and 156 months after injury. Seven patients required tracheotomy on account of severe respiratory disturbance.
Adult↗
Assessment of visuoperceptual disturbance in children with spastic diplegia using measurements of the lateral ventricles on cerebral MRI.
The authors estimated perceptual disturbance in children with spastic diplegia from the difference between the visual and performance IQ scores (VIQ-PIQ) on the Wechsler Intelligence Scale for Children-Revised (WISC-R), having found a strong negative correlation between this score and the PQ obtained on the Frostig Developmental Test of Visual Perception (DTVP). The ratio of the areas of the posterior horns to the anterior horns (P/A) correlated negatively with visuoperceptual disturbance. This ratio can therefore be used to assess perceptual disturbance at an early age in children with spastic diplegia.
Adolescent↗
Morphological analysis of the human lower extremity based on the relative muscle weight.
Morphological study of the muscles of the lower extremity is necessary for the analysis of the muscular function and its relation with locomotion. In this study, the muscle weight of the lower extremities from 11 adult Japanese cadavers (6 males and 5 females, aged from 50 to 91 years old) were measured. The morphological characteristic of the human lower extremity is discussed based on the relative muscular weight. The largest muscles were the gluteus maximus (the extensor at the hip joint), the vasti muscles (the extensor at the knee joint) and the soleus (the plantarflexor at the ankle joint). These results reveal that the muscles acting on one joint are developed in the human lower extremity and that these muscles have important roles in human locomotion.
Aged↗
Effects of aging on P3 components of somatosensory event-related potentials elicited by different stimulus conditions. Conventional averages and single-trial analysis.
Effects of aging on P3 components of somatosensory event-related potentials (ERPs) under different stimulus conditions were studied in healthy subjects using conventional averages and single-trial waveform analysis. The P3 component elicited by target stimuli (target P3) and that elicited by rare nontarget stimuli (nontarget P3) showed significant latency prolongation with age at the rate of 1.6 and 2.0 ms/year, respectively. The nontarget P3 showed a greater trial-to-trial fluctuation of single-trial latency than the target P3, probably because 'passive attention' was more liable to fluctuate. The variabilities of single-trial target P3 latency and of single-trial nontarget P3 latency were not correlated with age. Thus, the P3 latency prolongation with age might not be attributable to fluctuation in latency resulting from impairment of attention with aging.
Adult↗
Characterization of edema by diffusion-weighted imaging in experimental traumatic brain injury.
The objective of this study was to use diffusion-weighted magnetic resonance imaging (DWI) to help detect the type of edema that develops after experimental trauma and trauma coupled with hypotension and hypoxia (THH). Reduction in the apparent diffusion coefficients (ADCs) is thought to represent cytotoxic edema. In a preliminary series of experiments, the infusion edema model and middle cerebral artery occlusion models were used to confirm the direction of ADC change in response to purely extracellular and cytotoxic edema, respectively. The ADCs increased (p<0.05) in the case of extracellular edema and decreased (p<0.001) in cytotoxic edema. Following these initial experiments, a new impact acceleration model was used to induce traumatic brain injury. Thirty-six adult Sprague-Dawley rats were separated into four groups; sham, trauma alone, hypoxia and hypotension (HH), and THH. Following trauma, a 30-minute insult of hypoxia (PaO2 of 40 mm Hg) and hypotension (mean arterial blood pressure (MABP) of 30 mm Hg) were imposed and the animals were resuscitated. The DWI was carried out at four 1-hour intervals postinjury, and MABP, intracranial pressure (ICP), cerebral perfusion pressure (CPP), and cerebral blood flow (CBF) were monitored. The ADCs in the control and HH groups remained unchanged. The ADCs in the THH group rapidly decreased from a control level of 0.68 +/- 0.05 x 10(-3) mm2/second to 0.37 +/- 0.09 x 10(-3) mm2/second by 3 hours posttrauma (p < 0.001). In this group, the decreased CBF and CPP during secondary insult remained low despite resuscitation, with the ICP increasing to 56 +/- 7 mm Hg by 3 hours. In the trauma alone group, the rise in ICP reached a maximum value (28 +/- 3 mm Hg) at 30 minutes with a significant and sustained increase in CBF despite a gradual decrease in CPP. The ADCs in this group were not significantly reduced. The data lead the authors to suggest that the rise in ICP following severe trauma coupled with secondary insult in this model is predominately caused by cytotoxic edema and that ischemia plays a major role in the development of brain edema after head injury.
Animals↗
High-resolution CT findings in the development of the sphenooccipital synchondrosis.
PURPOSE: To evaluate the development of the sphenooccipital sychondrosis as seen on high-resolution thin-section CT scans. METHODS: We retrospectively reviewed the records of 253 patients, ages 1 to 77 years old, who had had thin-section CT examination of the skull base. RESULTS: An ossification center appeared midline in the patients who were 8 to 13 years old. Six of 12 girls showed additional symmetric ossification centers on either side of the midline; however, this pattern was not seen in boys. No sphenooccipital synchondrosis persisted in any patient past the age of 13 years. CONCLUSION: High-resolution CT scans of the skull base can show a pattern of progressive ossification of the sphenooccipital synchondrosis, which can be readily recognized and predicted.
Adolescent↗
Atrophy of bilateral extraocular muscles. CT and clinical features of seven patients.
Swelling of the extraocular muscles is a common orbital abnormality that is easily demonstrated by computed tomography (CT). However, muscle atrophy is more difficult to identify and is rarely reported in the literature. Bilateral atrophy is extremely rare. We report the CT and clinical features of seven patients showing bilateral extraocular muscle atrophy: four with mitochondrial myopathy (MM) and three with myasthenia gravis (MG). Six patients had clinical histories of muscle involvement > 20 years. An incorrect diagnosis of MG was made initially in two patients with MM because of mildly positive Tensilon testing. The ocular motor abnormalities failed to improve after thymectomy in the myasthenic patients. Orbital appearance on neuroimaging is similar in these disorders. Differentiation between these two disorders is impossible with orbital CT and magnetic resonance imaging (MR) alone.
Adult↗
Localization of trigeminal sensory innervation to the tongue and pharynx of the cat using horseradish peroxidase as tracer.
Trigeminal sensory innervation to the tongue and pharynx was investigated in the cat, using horseradish peroxidase (HRP) as a retrograde tracer. Following HRP application to the tongue, cells were labeled primarily in the posterolateral portion of the trigeminal ganglion. The pharynx was divided according to classical methodology into three regions: the epipharynx (nasopharynx), mesopharynx (oropharynx), and hypopharynx. When HRP was applied to the epipharynx and mesopharynx, HRP-labeled cells were found in the anteromedial and posterolateral portions of the trigeminal nerve, respectively. When HRP was applied to the hypopharynx, a single labeled cell was found in the trigeminal ganglion. These results indicate that trigeminal sensory nerve fibers in the cat branch to the tongue, epipharynx, and mesopharynx, but rarely to the hypopharynx.
Animals↗