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Biomedical subjects

J Ireland

Publications and source records attributed to J Ireland.

At least 55 records · Page 3Linked to original sources

The micropathology of the typical carpal tunnel syndrome.

The synovial membrane in the carpal tunnel of twenty-nine patients suffering from the typical clinical picture of carpal tunnel syndrome was examined microscopically over an eighteen month period with a follow-up of six months to two years. Unusual causes such as tendon sheath tumours and post-Colles fractures were excluded. Three micropathological pictures emerged. Oedema was found in twenty-four patients, chronic perivascular inflammation in three and fibrinous synovitis in two. No difference was detected in the clinical presentation in the three pathological appearances. The authors believe that oedema is the typical picture and the other two appearances could indicate irritation of the synovial membrane as a result of finger activity.

Carpal Tunnel Syndrome↗

Plantar fasciitis.

Thirty patients presenting with the heel pain syndrome, commonly referred to as "plantar fasciitis", were studied prospectively over a two year period. The pain was associated with a calcaneal spur in 21 patients (70%). In a control series of 25 patients without heel symptoms, calcaneal spurs were present in only 4 out of 50 heels (8%). This difference is highly significant (p 0.001). Seven patients (22%) in the plantar fasciitis group complained of ipsilateral sciatica.

Adolescent↗

The treatment of delayed union and non-union of the carpal scaphoid by screw fixation.

A simple technique for screw fixation of the carpal scaphoid in cases of delayed union and non-union is described. The results obtained in 32 patients treated by this method are reported. The average follow-up was three years ranging from 10 months to 12 years. Union was obtained in 28 patients. The causes of failure to unite are discussed and the advantages of the reported method over other techniques such as bone grafting are stressed.

Accidents↗

Lack of shared lymphocyte-stimulating determinants between H-2I and HLA-D/DR using mouse primed lymphocyte typing cells.

A number of anti-H-2 alloantisera containing antibody reactive with I region gene products (Ia) of the major histocompatibility complex cross-react with determinants expressed by human peripheral blood B lymphocytes. Such data have led to the conclusion that Ia and DR antigens share cross-reacting determinants. We have attempted to generate mouse primed T lymphocyte populations specific for defined I region gene product determinants which concomitantly recognize DR determinants on human peripheral blood leukocytes in primed lymphocyte typing (PLT) analysis. Mouse PLT cells were generated in primary MLC using strain combinations identical to those in which positive mouse/human cross-reacting antisera have been obtained. The resulting PLT cells exhibited strong, yet specific, secondary MLC responses against mouse cells expressing the Ia determinants used as the primary stimulus. In contrast, when examined on panels of human peripheral blood leukocytes, no reactivity was detected. This lack of cross-reactivity suggests that mouse T cells primed toward Ia determinants do not regularly recognize cross-reacting determinants of DR or D-associated antigens expressed on human PBLs. Consequently, mPLT cells are not a useful reagent in defining HLA-D region polymorphism.

Animals↗

Control and induction of ovulation in cattle.

The control and induction of ovulation in cattle are discussed with particular reference to use of progesterone-impregnated coils in heifers and beef cows. Progesterone treatment for 14 days was required to obtain precise onset of oestrus. With 7, 9 or 12 days of progesterone treatment a luteolytic agent in the form of a prostaglandin (PG) or oestradiol benzoate had to be used. Fertility was normal after treatment durations of 7, 9 or 12 days, but fertility after 14-day treatment requires further testing. The progesterone coil was not effective in maintaining luteal-phase levels of progesterone throughout a 12-day treatment and increasing the concentration of progesterone in the coil from 4 to 20% was not effective in elevating the progesterone concentrations in blood. When progesterone concentrations dropped below approximately 1.5 ng/ml the basal level of LH began to rise before removal of the coil. A 2-fold rise in the basal level of LH was observed following the removal of the progesterone coil. This early rise in LH was absent in cows which did not ovulate after they were given a 12-day progesterone treatment and GnRH 24-36 h after removal of coils to induce the main LH peak. Absence of this early rise suggests that frequency and amplitude of episodic LH release were inadequate in the post-partum anovulatory period. Ovariectomy in the early post-partum period was not followed by an abrupt LH release.

Animals↗

Arthroscopy and arthrography of the knee: a critical review.

A series of 135 knee arthroscopies has been reviewed to determine the accuracy of detection of meniscal lesions. Arthroscopy and double-contrast arthrography achieved similar accuracy (84 per cent and 86 per cent) in the diagnostically more difficult knees of the series. The combined accuracy of both examinations was 98 per cent. Arthroscopic difficulty in seeing the posterior third of the medial meniscus, and consequently tears in this region, is emphasised and discussed. Arthroscopy and arthrography are complementary in the diagnosis of difficult meniscal problems.

Adolescent↗

Macintosh tenodesis for anterolateral instability of the knee.

Fifty patients who underwent a MacIntosh repair for anterolateral instability of the knee have been reviewed after a mean follow-up of two and a quarter years. The repair abolished a positive anterolateral jerk test in 42 out of 50 knees and at the time of review 37 patients (74 per cent) were involved in some form of active sport, having regained functional and clinical stability. The MacIntosh repair is described in detail and the importance of excluding meniscal lesions as the main cause of instability is emphasised.

Adolescent↗

Clients' treatment expectations at a community mental health center.

Clients' expectations about mental health care, particularly differences in these expectations as a function of social class, and the relationship of discrepancies between expectations and perceptions to treatment outcome, is examined in this study with 317 Caucasian clients. In contrast to the majority of studies, no differences in treatment expectations relating to clients' social class, sex, or marital status were found. Nor were discrepancies related to course or outcome of therapy. Discussion focuses around explanation and interpretation of these findings. Particularly relevant is the need to determine the extent to which nonusers in the community share the attitudes and expectations of clients.

Adolescent↗

Triplane osteotomy for severely slipped upper femoral epiphysis.

Intertrochanteric osteotomy gives compensatory correction for the severely slipped upper femoral epiphysis without endangering its blood supply. The results of thirty-five such osteotomies carried out over an eighteen-year period are reviewed. The indication for operation was a chronic slip of a third or more of the growth plate in the lateral radiograph. The mean age at operation was fourteen years and the mean follow-up period seven and a half years. The results showed that even a moderate correction of deformity as shown by the radiograph could produce a hip with a functionally satisfactory range of movement. Chondrolysis was the most serious complication and occurred in four hips. The radiological results are discussed in relation to details of operative technique and also to long-term prognosis.

Adolescent↗

Developing a rural mental health service from a base in an academic clinical psychology program.

The development of a Community Mental Health Service for a multiethnic rural area by an academic psychology department clinical program was carried out for the purpose of providing relevant training for grauate students through realistic service functions. The population served was largely lower socioeconomic, and the available resources very limited. The Community Psychology course was used to assist the planning and negotiating for the clinic. Services provided during the first year are summarized. The graduate students' not-too-happy view of the program is presented. The problems and issues raised by this experience, for both training and service, are discussed.

Community Mental Health Services↗