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Biomedical subjects

J Iqbal

Publications and source records attributed to J Iqbal.

At least 127 records · Page 7Linked to original sources
PubMed1986

Mobile phase optimisation in the separation of antiepileptic drugs by high-performance liquid chromatography.

A simple method is described for adjusting the mobile phase composition to obtain optimum separation of commonly prescribed antiepileptic drugs by high-performance liquid chromatography. The drugs are separated, in less than 6 min, on a column of Hypersil ODS 5 microns (100 mm X 5 mm i.d.) with a high mobile phase flow rate. The final mobile phase composition is a mixture of methanol, acetonitrile, tetrahydrofuran and water, adjusted to give the best separation with our laboratory conditions. The method is described and evidence of precision and accuracy presented. The improved separation resolves the major metabolites of carbamazepine which have been ignored in most methods for antiepileptic drugs. The advantages of mobile phase optimisation to improve the separation of antiepileptic drugs are discussed.

Anticonvulsants↗
PubMed1984

Ipsilateral hemiplegia and the Wallenberg syndrome.

We documented the anatomic basis for hemiplegia occurring on the same side of the body as the lateral medullary infarction. Extension of the zone of ischemia into the rostral spinal cord involves corticospinal fibers after they cross from the opposite side.

Aged↗
PubMed1980

A family segregating for E1j and E1k at cholinesterase locus 1.

A family segregating for the A, J, and K alleles at cholinesterase locus 1 is described. Several further examples of the AJ and AK phenotypes occur in this family, and one member of the family, by genetic analysis, is phenotype JK. In relation to possible succinylcholine apnoea, phenotypes AJ, AK, and JK should all be considered vulnerable.

Adolescent↗
PubMed1978

Adrenocortical suppression in workers manufacturing synthetic glucocorticoids.

A man who had worked for 16 years in the manufacture of a potent corticosteroid was found to be suffering from chronic adrenocortical insufficiency attributed to chronic absorption of the glucocorticoid. Eleven other symptom-free workers were therefore screened. Two of these workers, like the first patient, gave grossly abnormal responses to the Synacthen (tetracosactrin) test; one had been employed for only seven months. All 12 men had facial plethora, suggesting absorption of the drug in spite of their having adhered to the safety precautions. All workers manufacturing potent steroids should therfore be screened regularly by measurement of their plasma cortisol concentrations and should be moved regularly to processing other drugs.

Absorption↗
PubMed1977

Preliminary screening of amino acids excretion in the urine of newly born babies.

The paper attempts to characterize the qualitative as well as quantitative estimations of aminoacids in the urines of new born babies using two dimensional paper chromatography. The objective of this investigation was to know the extent of amino acid defects in these samples and to correlate such defects with the physical abnormalities in infants. Based on the overall results, it is inferred that phenylalanine excreted in the urine gave a positive response with PKU test and some particular amino acids are identified and estimated in the urine of new born babies to confirm the diagnosis of phenylketonuric patients.

Amino Acids↗