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Biomedical subjects

J Ionescu

Publications and source records attributed to J Ionescu.

29 records · Page 2Linked to original sources
PubMedDate not supplied

Histoenzymology of the lung. V. Histoenzymatic analysis of sixty lung tumors.

A series of sixty lung tumors operated during 1977 were histoenzymatically investigated (12 macrocellular carcionomas, 4 microcellular, 18 epidermoid, 18 cylindrocubic, 2 bronchiolo-alveolar cell carcinomas, 4 lung fibroblastic sarcomas, and 2 benign lung tumors: a haemangioma and a carcinoid tumor). There were tested 25 enzymes, hydrolases and oxidoreductases of different metabolic pathways. The histoenzymatic analysis of the neoplastic lung tissue compared with the normal adult human lung tissue pointed to a shifting of the metabolic balance, with the decrease of enzyme activities belonging to the Krebs tricarboxylic acid cycle and with the increase or maintenance of the level of enzymic activities belonging to the Embden-Meyerhoff-Parnas pathway and to the pentose shunt. The enzymes intervening in the protidic activity in all the malignant tumors of the lung. Some hydrolases were also more active lung tissue pointed out the existence of close relations between the normal epithelia and the cylindrocubic and bronchiolo-alveolar types, and of distant ones with the epidermoid and microcellular carcinomas which suffered more accentuated ecogenetic influences (stopping of differentiation/maturation, metaplasia) during the complex oncogenetic process.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMedDate not supplied

Recurring thoracal mesenchymoma.

A four-times-recurring thoracal mesenchymoma is presented. Each tumor evolved for 2-5 years before resection, the general evolution of the case being of about 30 years. Histologically, the tumors, which involved the thoracal wall presented at the same time the predominating fibroblasto-fibrocytic structure sometimes forming whirls, different mesenchymal derivatives as vessels and angiomatous formations, osseous trabeculae, chondroblastic areas, and more or less dense zones with leiomyocytes sometimes forming myomatous and myofibromatous aspects. Mitoses and nuclear atypias were very rare. The diagnosis of benign recurring mesenchymoma of the thoracal wall and pleura is discussed.

Humans↗
PubMedDate not supplied

Eosinophilic granulomas of the lung. Histopathology of three cases.

Three cases of eosinophilic granuloma of the lung were histopathologically analyzed on surgical materials (two resections and lung biopsy). The analysis insisted upon the cell components of pulmonary lesions, histiocytic and eosinocytic accumulations involving lobular air spaces, alveolar walls and interlobular areas, and forming bullae by histiocytic enzymic activity and lipid dysmetabolism; the fibrotic evolution of the lesions varied from case to case. The lesional histogenesis is discussed in the light of recent electronmicroscropic, histochemical and immunopathological data, stress being laid upon the local influence on the development of the process.

Adult↗
PubMedDate not supplied

Bronchiolar pathology. IV. a morphometric analysis of the incidence and location of lesions induced in rabbits by intratracheally injected detergent solutions.

An experimental model of bronchiolar lesions was elaborated. It consisted of three intratracheal administrations in rabbits of 2 ml of a 3 per cent detergent solution, pH 2.5-3; the adequate development of the process was induced when the second injection was given 48 h after the first and the third on days 5-6. The induced process evolved during three phases: a) hypertrophy with hyperfunction of Clara cells, cell beheading by apo- and merocrinia and denudation of basement membranes; b) lesions of subepithelial components, mainly of capillaries, with granulative response and restructuration of the peribronchiolar tissue, and c) tardy regenerative response of epithelial cells, sometimes with neoformation of bronchioli. The morphometric analysis of this experimental process asserted the validity of the model which led to damages involving at less 70 per cent of the bronchioli (under 200 epithelial nuclei on a circumferential section) and of the small bronchi (with 200-500 epithelia nuclei); the other small and large bronchi were never involved. The morphometric analysis also showed the relations of the intervals between injections to the lesional intensity and stereotyping.

Animals↗