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J Ikeda

Publications and source records attributed to J Ikeda.

176 records · Page 10Linked to original sources
PubMedDate not supplied

Immunohistochemical analysis of platelet-derived growth factor-B expression in myocardial tissues in hypertrophic cardiomyopathy.

Intimal and/or medial hyperplasia of intramyocardial small vessels is thought to be one of the causes of myocardial ischemia in hypertrophic cardiomyopathy (HCM). However, the pathogenesis of such vascular lesions in HCM is not yet known. To evaluate the pathogenic role of platelet-derived growth factor (PDGF-B) and basic fibroblast growth factor (b-FGF), which have a potential to induce cellular and molecular changes observed in the vessels in HCM, we examined the expression of these molecules and PDGF receptors in cardiac tissues from six patients with HCM and seven controls using immunohistochemistry. The percentage of PDGF-B positive cells in the myocyte population in HCM was significantly higher than that in controls (52.6 +/- 16.2 (mean +/- SD) vs. 21.6 +/- 9.6, p < 0.01). PDGF-B was also observed in vascular regions in HCM (61.1 +/- 25.5% of arterioles) but not in controls. There were no significant differences in the expression of b-FGF and PDGF receptors in the myocyte and non-myocyte populations and the vascular regions between the HCM and control groups. Our study revealed that the expression of PDGF-B protein was up-regulated in HCM, suggesting the contribution of this molecule to the development of intramyocardial vasculopathy.

Adolescent↗
PubMedDate not supplied

A new surgical procedure for aged burn victims: applications of dermolipectomy for burn wounds and donor sites.

A new surgical method for use on both burn wounds and donor sites of elderly patients with burns is presented. This procedure is based on dermolipectomy. During the period from January 1985 to December 1988, 20 operations were performed on 18 patients. This procedure was applied to 39 donor sites and to four burn wound sites. The most common donor site was the lateral trunk. There was only one postoperative death. Actual survival rates and predicted survival rates were compared, and in those patients with burns over 21% to 40% of total body surface area actual survival rates were better than the predicted rates.

Aged↗