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Biomedical subjects

J Huntington

Publications and source records attributed to J Huntington.

36 records · Page 2Linked to original sources
PubMed1989

New alkyl N,N-dialkyl-substituted amino acetates as transdermal penetration enhancers.

New alcohol derivatives of N,N-disubstituted amino acids with a low toxicity have been synthesized and evaluated for their transdermal penetration enhancing effects on the transport of indomethacin from petrolatum ointments across shed skin of black rat snake (Elaphe obsoleta). The derivatives show excellent penetration enhancement of indomethacin, as high as 3.8 times that of Azone, with decyl N,N-dimethylamino acetate as the lead compound in the series. The release of indomethacin from an ointment containing 1% indomethacin, 5% dodecyl N,N-dimethylamino acetate, and 94% petrolatum was 3.15 micrograms/min1/2/cm2. Saturation studies performed by incorporating varying concentrations of indomethacin, from 0.1 to 10%, into the ointments and determination of the fluxes of indomethacin demonstrated that the saturated concentration of indomethacin in petrolatum base was approximately 1%. Penetration fluxes of indomethacin (1%) through snake skin increased linearly as the concentration of dodecyl N,N-dimethylamino acetate increased from 2.5 to 15%. Experiments involving the pretreatment of the snake skins with dodecyl N,N-dimethylamino acetate indicated that pretreatment of the skin increased the skin permeability significantly. Electron micrograph studies on the snake skin treated with dodecyl N,N-dimethylamino acetate show clearly that the enhancer interacted with both the lipid-rich layer (mesos phase) and the keratin-rich layers (both alpha and beta phases).

Alkanes↗
PubMed1988

Unsaturated cyclic ureas as new nontoxic biodegradable transdermal penetration enhancers I: Synthesis.

A new concept was implemented to reduce the toxicity of some new biodegradable transdermal penetration enhancers. These enhancers consist of 1-alkyl-4-imidazolin-2-one and a long-chain alkyl ester group at the N-3 position. The synthesis involves N-alkylation of the parent compound with soft alkylating agents which were prepared in high yields by an improved method. A phase transfer catalysis technique using KOH as the base, tetrabutylammonium bromide as the catalyst, and toluene as the solvent was found to be most effective in the N-alkylation step.

Adjuvants, Pharmaceutic↗
PubMed1986

The proper contributions of social workers in health practice.

Current and potential future contributions of social workers to health practice are considered at the three levels of direct service to patients, influence on the processes and procedures of the health setting and influence on its future planning and service development. The capacity of U.S.A. and U.K. social work to contribute at these levels is compared in the light of their contrasting relationships to the health system. U.S.A. social work in health care is practised as employees of the health setting or as private practitioners and contains the majority of U.S.A. social workers. It remains a specialism that sustains a major body of published work, commitment to knowledge-building, standard setting and performance review, and a psycho-social orientation shared by a growing number of medical and nursing professionals. Its approach to the health system is that of the pursuit of professional credibility in the secondary setting by adopting the professional-technical practice model of the clinician. U.K. social work since the early 1970s has been committed to generic education and practice and to the development of its own primary setting in social services departments which now employ almost all U.K. social workers. Area team social work in these departments, typified by statutory work with the most deprived sections of the population, has become the dominant culture of British social work, with implications for the occupational identity and career prospects of those social workers who are outposted or attached to health settings but no longer employed by them. British social work and its management now approach the health system from a position of organizational independence which should strengthen their capacity to influence the health system. The cultural differences between social work and medicine, however, are experienced more keenly than ever as many social workers adopt a socio-political practice model that is at odds with the professional-technical model of the clinician. Provision of social work services to the health system has become a questionable priority and raises the issue of whether much of what is now termed "health care' could more appropriately be termed "social care' and provided in a primary social work setting to which medicine and nursing would make their "proper contributions'.

Counseling↗
PubMed1986

Effects of incubation temperature and bicarbonate on maturation of pig oocytes in vitro.

Pig oocytes cultured at 39 degrees C had a higher percentage of polar body formation than did those cultured at 37 degrees C. A culture medium based on Medium 199 with Earle's salts and supplemented with 15% serum from a young castrated boar was just as good as the same formulation containing additional pyruvate, lactate and insulin, and superior to a modified Krebs-Ringer bicarbonate medium. When the bicarbonate buffer system (Earle's salts) of Medium 199 was replaced with a phosphate buffer system (Hank's salts), the rate of polar body formation was decreased. When the Hank's based medium was supplemented with a bicarbonate buffer system, polar body formation was restored to the level in Earle's based medium. This suggests that CO2/bicarbonate may be important for the normal maturation of pig oocytes.

Animals↗
PubMed1981

Multiple biological activities of homogeneous human alpha interferon.

To identify the active molecule in human alpha interferon preparations, we performed several studies, using both partially purified interferon and homogeneous interferon. Our results indicated that there is little difference between the partially purified and the homogeneous interferon preparations in terms of antiviral activity, inhibition of deoxyribonucleic acid synthesis in human neoplastic cells, and enhancement of human natural killer cell activity.

Cells, Cultured↗
PubMed1981

Nurse, where are you?

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American Nurses' Association↗
PubMed1978

"Who cares?" A comment on the Australian general practitioner.

The recent Australian publication "Who cares?" offers the family medicine student and the family physician: Affirmation of the preminence of the GP as the professional of first resort for a wide range of Australian families. A typology of families in terms of the way they relate to health care and its providers. A picture of the experience of health care offered to some Australian families, and its relevance to their condition. A typology of GPs in terms of their willingness to extend their role to include the family's total 'welfare'. Criticism of the GP in failing to refer patients to existing community services. Implications for medical education in terms of development of the GP's communication skills in relation to both patients and other health and welfare professionals.

Australia↗
PubMed1976

Social work and general practice: a review article.

Closer collaboration with social workers may be a means of enabling the general practitioner to deal with the psychosocial problems expressed in his practice. Emerging interest on the part of general practitioners in exploring the potential contribution of the social worker to patient care is accompanied by some anxiety and ambivalence. Reports of collaborative projects have come mainly from the United Kingdom, and although these offer some guidelines, it is imperative that any policy proposals for the development of closer general practitioner-social worker collaboration in Australia be grounded in an Australian data base.

Attitude of Health Personnel↗
PubMedDate not supplied

Testing the pilots.

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Air Ambulances↗