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Biomedical subjects

J Hugon

Publications and source records attributed to J Hugon.

At least 109 records · Page 6Linked to original sources
PubMed1987

[Methodology and normal values in recording evoked motor potentials following transcranial stimulation in the human].

Electric non-invasive stimulation of the motor cortex was performed in 19 healthy subjects. Muscle responses were recorded with surface electrodes from the abductor, pollicis brevis and anterior tibial muscle. The mean central motor latencies for pathways regulating the function of the upper limbs was 4.5 msec (standard deviation 0.5 msec), the corresponding latency for the lower limbs was 9.6 msec (standard deviation 1.2 msec). The reproducibility of latencies and configuration of the potentials obtained indicates that the method described can be used as a reliable method in the diagnosis of affections of the motor system.

Electric Stimulation↗
PubMed1986

Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA.

Lathyrism, a form of motoneuron disease induced by excessive consumption of th legume Lathyrus sativus (chickling pea), presents as signs of pyramidal tract involvement. Primate feeding studies show that beta-N-oxalylamino-L-alanine (BOAA), a potent neuroexcitatory aminoacid in the chickling pea, induces corticospinal dysfunction similar to that seen in animals consuming a fortified diet of this legume. BOAA, a potent agonist of the excitatory neurotransmitter glutamate, is likely to be causally associated with lathyrism in man.

Adolescent↗
PubMed1986

Amyotrophic lateral sclerosis in Limousin (Limoges area, France).

Several epidemiological studies of amyotrophic lateral sclerosis have suggested that this neurological disease is uniformly distributed throughout the world. We report here the only study providing data on the incidence of this disease in France. It is based on a retrospective study of the Limoges region (Limousin) which contains only one university department of neurology. The study, conducted from February 1, 1977, to February 1, 1985, was not limited to in- and out-patients seen at this department, as we also contacted other non-hospital doctors who might have examined such patients. The average normal incidence was found to be 0.91 per 100,000 population. The male:female ratio was 1.16:1, and the median age of onset was 65 years. Median survival was 20.7 months.

Actuarial Analysis↗
PubMed1986

Acute pure sensory paraneoplastic neuropathy with perivascular endoneurial inflammation: ultrastructural study of capillary walls.

We studied a patient with epidermoid carcinoma of the lung (treated surgically 1 year earlier) and an acute symmetric pure sensory neuropathy that regressed almost completely within 1 month. Superficial peroneal nerve biopsy 15 days after onset showed evidence of demyelination with perivascular endoneurial inflammation. On ultrastructural examination, lymphocytes were seen passing through endothelial cells of endoneurial capillaries.

Capillaries↗
PubMed1985

Myasthenia gravis associated with adrenocortical insufficiency. Report of two cases.

Two cases of Addison's disease associated with myasthenia gravis are reported. This association has been described only rarely in the literature. In the first case, there were marked immunological abnormalities. It is most likely that the origin of the adrenocortical insufficiency in the second case is tuberculous. The pathogenetic mechanism of these associations is briefly discussed.

Addison Disease↗