Variants of the Bomirski family of hamster melanomas whose proliferative rates differ inversely with the genetically determined degree of melanogenesis were probed for two proteins critical in melanogenesis: tyrosinase and catalase-B (gp 75). The parental black tumor Ma contained both proteins in abundance. The amelanotic variant Ab, inducible in culture with L-tyrosine or L-dopa to form melanosomes and to melanize, had minimal tyrosinase, despite high levels of (tyr)mRNA, and no gp 75. Variant MI, hypomelanotic despite abundant tyrosinase, and synthesizing predominantingly pheo-(red) melanin, expressed barely detectable gp 75. These findings suggest a regulatory control of melanogenesis distal to (tyr)mRNA and strengthen the hypothesis that in vivo tyrosinase without catalase-B favors pheo- over eumelanogenesis.

Animals↗

PubMedDate not supplied

The long-term effects of spinal fusion on the sacroiliac joints and ilium.

Ninety-six patients who had lumbar disk excision and primary posterior fusion were studied 10 or more years after their operations. Thirty-seven per cent complained of persistent graft donor site pain. A comparison of fused patients with and without donor site pain and 36 patients who underwent simple disk excision, revealed no differences in the flexion-extension mobility of the sacroiliac joints, or degenerative changes in the sacroiliac joints. Ectopic bone formation at graft donor sites, and cluneal nerve neuromata did not influence the result. Patients with graft donor site pain had significantly greater complaints of persistent low back pain, postoperative leg pain, and lost more time from work. If the graft was taken from the same side as that of preoperative leg pain, persistent complaints were more common. It is concluded that the sacroiliac joints are not adversely affected by lumbar spine fusion, and that persistent donor site pain is more likely part of a total pain complex referred from the lumbar spine. The sacroiliac joints appear to be relatively noncontributory to problems following lumbar disk surgery.

Bone Transplantation↗

PubMedDate not supplied

[Support in dying: orientation of expectations and needs of dying patients].

Experience and behavior of dying people are on a lot of variables. Age, cultural background, human relations, personality and environment are some of these determinants. For an appropriate care for the dying it is necessary to perceive and realize the expectations and requirements of the dying person. The human relationships get an important role. Barton (1977) developed a complete conception. Accompanying a dying person in a nursing home for the old demands an answer on many organizational questions.

Adaptation, Psychological↗

PubMedDate not supplied

AIDS focus. Advertising HIV.

Explore the source record for details and available documents.

Advertising↗

PubMedDate not supplied

HIV/AIDS education: philately will get you everywhere.

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Acquired Immunodeficiency Syndrome↗

PubMedDate not supplied

Sex and sensibilities.

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Ethics, Nursing↗

PubMedDate not supplied

Chiropractic radiologists: a survey of demographics, abilities, educational attitudes and practice trends.

OBJECTIVE: To assess the education, abilities, practices and opinions of chiropractic radiologists. DESIGN: Eight-page survey with two mailings. PARTICIPANTS: One hundred seventy-five diplomates of the American Chiropractic Board of Radiology listed with the American Chiropractic College of Radiology office. RESULTS: Of the surveys mailed, 111 of the 175 were returned from the individuals listed with the American Chiropractic College of Radiology office. After excluding the deceased and those with a self-reported retired status, the response rate was calculated as 66%. Of those who responded, 81% were male; the mean age was 46.4 +/- 11.2 yr (mean +/- standard deviation). Most respondents were residents of California, followed by Canada and Illinois. Thirty-six percent taught at chiropractic colleges. They felt most confident in interpreting plain film studies of the musculoskeletal system. Many have undergone advanced training in specialized imaging. They felt topics related to patient positioning, plain film physics, arthritides, trauma, avascular necrosis and tumors are most important to a chiropractic curriculum. Most respondents felt the use of plain film radiology was most appropriate when the clinical presentation of the patient suggests the strong possibility of underlying disease. CONCLUSIONS: Radiology is an important topic to the education of students and the practice of chiropractic. The results of this survey will assist future decision-making regarding student education and clinical use of radiology.

Adult↗