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Biomedical subjects

J Hovorka

Publications and source records attributed to J Hovorka.

At least 37 records · Page 2Linked to original sources
PubMed1984

Modification of aspects of the endocrine response to tracheal intubation by lignocaine, halothane and thiopentone.

The effects of two different concentrations of halothane (0.5 or 1.5%) and two different doses of thiopentone (4.5 or 10 mg kg-1) on the plasma concentrations of cortisol, growth hormone (GH) and prolactin (PRL) were studied in response to the stress of tracheal intubation. Additionally, the effect of the intratracheal administration of 4% lignocaine spray 2 ml was investigated. The study group included 48 healthy women. During a "light" level of halothane and thiopentone anaesthesia, the plasma concentration of cortisol increased in response to tracheal intubation in the patients who did not receive intratracheal analgesia. Topical analgesia with lignocaine prevented the increase in cortisol concentration and this would seem to indicate that the increase was caused by the stress of laryngoscopy and intubation. At a deeper level of halothane anaesthesia, and in association with the larger dose of thiopentone the increase in cortisol concentration was suppressed. GH did not change from the preanaesthetic value in any group and there were no differences between the control group and the study groups. PRL increased significantly in all groups. Increasing the dose of thiopentone caused a further increase in PRL concentration which indicated a direct stimulatory action of thiopentone on PRL release.

Administration, Topical↗
PubMed1984

Effect of intratracheal lignocaine, halothane and thiopentone on changes in plasma beta-endorphin immunoreactivity in response to tracheal intubation.

Alterations in the concentration of plasma beta-endorphin immunoreactivity (beta-EPir), in response to the stress of tracheal intubation, were measured in 48 women during halothane anaesthesia. The increase in plasma beta-EPir in response to tracheal intubation could be prevented by topical analgesia (4% lignocaine 2 ml) to the trachea, a deeper level of halothane anaesthesia (1.5%) and an increased dose of thiopentone (10 mg kg-1). It was concluded that a low plasma beta-EPir value is a sign of stress-free anaesthesia and that measurements of plasma beta-EPir may be useful in determining the degree of stress present during various anaesthetic procedures.

Administration, Topical↗
PubMed1983

Recovery after general anaesthesia for laparoscopy.

Recovery after two methods of light general anaesthesia for gynaecological laparoscopy was studied. For this purpose, 30 patients were divided into two equal groups (A and B). The patients in group A were anaesthetized with thiopentone, fentanyl and suxamethonium infusion, while the patients in group B received inhalation anaesthesia with enflurane and suxamethonium infusion. Both groups were normoventilated with nitrous-oxide and oxygen mixture. A battery of recovery tests was applied in the recovery room. The patients who received inhalation anaesthesia with enflurane scored better in the recovery tests, and reached preoperative values after 3 h in the recovery room. Inhalation anaesthesia with enflurane was accepted well by the patients and provided good working conditions for the surgeons. It is suitable for outpatient gynaecological laparoscopy because it ensures rapid recovery.

Anesthesia, General↗
PubMed1982

Carbon dioxide homeostasis and recovery after general anaesthesia.

The influence of different levels of carbon dioxide during general anaesthesia on postoperative recovery was studied. Sixty female patients were divided into two age groups. Thirty patients were over 60 years old and 30 patients were under 46 years old. Artificial ventilation with added carbon dioxide during general anaesthesia with thiopentone, nitrous oxide-oxygen, alcuronium and fentanyl was used. According to the arterial CO2 tension, patients were allocated to subgroups: hypercarbic, PaCO2 7.3 kPa, normocarbic, PaCO2 5.3 kPa and two different levels of hypocarbia: older patients PaCO2 3.7 kPa and younger patients PaCO2 2.9 kPa. As criteria for recovery, a battery of recovery tests and postoperative questionnaires were used. Regardless of age, patients subjected to hypercarbic ventilation scored better in the recovery tests than patients subjected to normo- or hypocarbia. Normocarbic ventilation also gave better results than hypocarbic ventilation. The level of hypocarbia used in the older patients and that used in the younger patients, though different, resulted in nearly the same deterioration of scoring in the recovery tests. This deterioration was seen in some patients up to 48 h postoperatively. No subjective differences were elicited from the questionnaires after various types of ventilation.

Adult↗
PubMed1975

[Effect of fenbendazole (Panacur) in sheep naturally invaded by gastrointestinal and lung nemtaodes].

The paper presents the results of the clinical tests of fenbendazole (Panacur, produced by Hoechst, F. R. G.), a new antihelminthic preparation. The tests were performed in sheep naturally invaded by gastrointestinal and lung nematodes. Helminthological dissection performed 7 days after the application of 5 mg of fenbendazole per 1 kg of sheep weight proved 100% effectiveness on lungworms (Dictyocaulus filaria) and on the following gastrointestinal helminths: Ostertagia ostertagi, Haemonchus contortus, Bunostomum trigonocephalum, Strongyloides papilosus, Chabertia ovina, Oesophagostomum venulosum, Trichostrongylus spp., and Nematodirus filicollis. The effect on the Trichocephalus ovis species was low and statistically insignificant (37.8%). The tolerance to the chemical was good even in sheep in a very bad condition.

Animals↗