Biomedical subjects

J Horvat

Publications and source records attributed to J Horvat.

39 records · Page 3Linked to original sources

PubMedDate not supplied

Synthesis and bioactivity studies of 1-adamantanamine derivatives of peptides.

Small enkephalin-related peptides containing a 1-adamantanamine moiety coupled through an amide linkage at the C-terminus were synthesized. Several of the compounds showed high mu opioid activity and mu receptor selectivity. The new adamantanamine derivatives were also examined for antiviral activity against HIV-1 in a cell culture system. Some of them inhibited syncytia formation even when the antigen assay gave evidence for viral replication.

Adamantane↗

PubMedDate not supplied

[Quality control of frozen plasma in 8 blood transfusion centers in the Croatian Republic].

Fresh frozen plasma (FFP) is one of the most frequently used blood components. Its use is continuously increasing, although 50 to 80% of units are not used according to the approved indications. The quality control of FFP was performed in 6 blood transfusion centers. The volume of FFP unit was between 178 and 234 ml. F VIII: C above 0.70 i. u./ml was observed in 40.9 of units. Plasma in 0.9% of units was not sterile and the concentration of total proteins and hemoglobin were within the acceptable range.

Blood Transfusion↗

PubMedDate not supplied

[Quality control of erythrocyte concentrates in 6 transfusion centers in Croatia].

Quality control of red cell concentrates (RCC) was performed in six Blood Transfusion Centres in Croatia. Between 1.5 and 3.7% of the produced or/and used RCC were examined. Large differences in volume and haematocrit were found between red cell concentrates. 63.2% of concentrates had a volume larger than 225 ml. The mean haematocrit was 65.5%, and a haematocrit above 65% was observed in 51.6% of RCC. From 3.5% of RCC bacteria were isolated (gram positive coccus, Staphylococcus albus, Staphylococcus epidermidis and Streptococcus haemolyticus). The quality of RCC was not found to be satisfactory. In order to improve their quality procedures for their production, standards and legal requirements have to be established.

Blood Transfusion↗