Biomedical subjects
J Holzworth
Publications and source records attributed to J Holzworth.
Thymoma in 11 cats.
Eleven thymomas, 10 benign and 1 malignant, were diagnosed in cats at the Angell Memorial Animal Hospital. Six cats were dyspneic, owing either to the pressure of the tumor or the associated effusion. The effusion in 1 instance contained chyle, and in another, malignant epithelial cells associated with satellite lesions. Three cats had polymyositis, as evidenced clinically by muscle weakness and confirmed by microscopic examination. Two of these also had myocarditis and difficulty in swallowing. In 1 cat, the primary disorder was an atypical, progressive, moist dermatitis that was unresponsive to treatment and that became so severely generalized that the cat had to be destroyed. The thymoma was discovered only at necropsy.U
Hyperthyroidism in the cat: ten cases.
In ten neutered crossbred cats 10 to 14 years old and of both sexes, hyperthyroidism was evidenced by hyperactivity, weight loss despite increased appetite, frequent defecation with bulky stools, thirst, polyuria, moderately elevated temperature, increased heart rate and size, sometimes with murmurs and arrhythmias, and palpable enlargement of one or both thyroid lobes. The diagnosis of hyperthyroidism was confirmed on the basis of high serum concentrations of thyroxine (T4) and triiodothyronine (T3). In seven cats (6 treated by total thyroidectomy, 1 studied at necropsy), both thyroid lobes were variably enlarged, mottled, cystic, or nodular; in three cats, only one lobe required removal. Adenomatous goiter was diagnosed microscopically in all. In two, there also were foci of adenocarcinoma and in two others, foci suggestive of adenocarcinoma. Three of the nine cats having surgery were treated preoperatively to stabilize cardiac function. Most cats recovered from surgery rapidly and without complications but although every effort was made to spare at least one parathyroid gland in cats having bilateral thyroidectomies, two cats had transient signs of hypoparathyroidism, requiring careful monitoring of serum electrolytes and treatment with calcium and vitamin D2. All having bilateral thyroidectomies were subsequently maintained on treatment with l-thyroxine or, in one case, liothyronine (triiodothyronine).
Treatment of leukemia in the cat.
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Naturally occurring feline leukemia: clinical, pathologic, and differential diagnostic features.
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Naturally occurring upper respiratory infection in cats.
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Naturally occurring feline infectious peritonitis: signs and clinical diagnosis.
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Immunology of feline virus diseases.
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