Biomedical subjects

J Holm

Publications and source records attributed to J Holm.

At least 289 records · Page 16Linked to original sources

PubMed1975

Technical considerations in arterial embolectomy.

The frequency of arterial embolism is high and seems to be increasing. The introduction of the Fogarty catheter for embolectomy has afforded a considerable simplification of the operative technique. Nevertheless the mortality and amputation rates are still substantially high. Early diagnosis and further improved technique for removal of the embolus may enhance limb salvage and reduce mortality rates. The present paper is a review of 10 years' experience concerning technical problems with embolectomy. The arteriotomy technique, the handling of the catheter, per- and postoperative management, and specific technical problems related to the embolic lodgement at different sites are discussed with the object of giving some hints on how to perform the embolectomy in a safe way and with best chances of a suscessful outcome.

Aorta↗

PubMed1975

The relationship between glycogen content of leg muscles and working capacity in patients with intermittent claudication.

The relationship between the glycogen content of the vastus lateralis muscle and the working duration was determined in 6 patients with intermittent claudication. The working duration was determined on a bicycle ergometer at a load of 450 kpm/min. Muscle glycogen was determined in percutaneous needle biopsy specimens. The resting glycogen content in the vastus muscle increased significantly after depletion of the stores by physical exercise followed by glucose feeding for 2 days. This increase was associated with an increased working duration. This improvement of the working duration connected with high muscle glycogen content was a temporary phenomenon. When the duration was measured shortly after exercise, i.e. after depletion of the glycogen stores it was reduced to the preexperimental level. The improved working duration associated with increased glycogen content of leg muscles did not seem to be related to the improved walking capacity in claudication patients after physical conditioning.

Aged↗

PubMed1975

Oxidation of palmitate by human skeletal muscles in vitro. Method and normal values.

The conditions of determination of the in vitro incorporation rate of palmitate-carbon into CO2 in human skeletal muscles were studied. Muscle biopsies were taken from 25 patients with nonmuscular diseases and incubated in a metabolic shaker with KRP as medium and palmitate as substrate. Substrate saturation was achieved beyond a palmitate concentration of 2.5 mmol/1, and the incorporation rate was linear with time for 2 hr. The activity of 3-hydroxy-acyl-CoA-dehydrogenase (ACDH), an enzyme involved in the beta-oxidation, was also determined. Both the incorporation rate of palmitate-carbon into CO2 and the activity of ACDH were higher in the leg muscles than in the abdominal muscles. Significant positive correlations were found between the incorporation rate of palmitate-carbon into CO2 and the ACDH activity, and between the incorporation rate and the phospholipid concentration in muscles. These correlations indicate that this in vitro system is valid for evaluation of the metabolism of fatty acids in skeletal muscle tissue.

Abdomen↗

PubMed1974