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Biomedical subjects

J Holle

Publications and source records attributed to J Holle.

At least 73 records · Page 4Linked to original sources
PubMed1981

[Microsurgical intervention in a case of Raynaud's gangrene].

In a case of typical Raynaud's gangrene a microsurgical therapeutic intervention has been tried. To interrupt the periarterial sympathetic nerve network, 1,5-2 cm of both collateral arteries of the affected right index finger were excised and replaced by two venous grafts. In addition both collateral nerves were dissected and reanastomosed for elimination of sensation and pain for some time. In the early postoperative time the patient was free of pain and started using the finger during daily life. 6 weeks after the operation a control-angiography was performed and since that moment the patient complained again of severe pain in the affected finger. The angiography had led to vascular spasm with consequent thrombosis of the patent ulnar venous graft. Because of the severe pain in the finger we were forced to amputate the finger.

Adult↗
PubMed1980

[Functional reconstruction of the striated sphincter muscle in the incontinent anus (author's transl)].

Anal sphincter reconstruction with muscle transplantation according to Thompson and transposition of the denervated gracilis muscle onto the surface of the pelvic floor muscles are described. The transplanted and transposed muscles are reinnervated by a collateral nerve from the adjacent functioning muscles. The follow-up examination of 16 cases of anal incontinence two years after anal sphincter reconstruction demonstrates in all but one case ontinence for firm feces and in most of them, continence for fluid feces. Reflectoric contractions of the new reconstructed sphincter can be demonstrated by myographic and manometric investigations. The advantages of dynamic sphincter reconstruction with muscular neurotization compared to other more static techniques are discussed.

Adolescent↗
PubMed1980

[Dynamic splinting in flexor tendon surgery].

Besides the special microsurgical operative technique, dynamic splinting is one of the basic fundamentals of KLEINERT's technique for primary repair of flexor tendons. The principle of this splinting is explained. Further applications are reported: 1. after secondary repair of flexor tendons (by tendon transfer or tendon transplantation), and 2. after tenolysis. According to our good results the application of dynamic splinting in the above mentioned cases seems to be advisable.

Fingers↗
PubMed1980

[Approach to digital replantation in childhood (author's transl)].

Replantation and revascularisation of amputated parts in children is demonstrated in relation to 6 and 8 cases respectively. The indications are discussed. Contra-indications are limited to a poor general condition as a result of multiple trauma or to severe destruction of the amputated part. The organisation of a replantation service id discussed briefly.

Adolescent↗
PubMed1979

[Reconstruction of the breast after surgery for cancer (author's transl)].

The tendency towards less radical, stage-dependent procedures in the surgical management of breast cancer has opened the way to improvement in the reconstructive measures available. Reconstruction of the female breast can be undertaken with greater or lesser success and facility according to whether the initial procedure was subcutaneous mastectomy, modified radical mastectomy or the Rotter--Halstedt radical operation. The different plastic reconstructive methods developed over the past years are discussed and illustrated by cases treated under our care.

Breast↗
PubMed1979

[Functional outcome after reimplantations in the hand and finger region].

Successful replantation of total amputated parts of the hand having been performed during a period of five years were investigated as a homogenous group. Long-term function of replanted parts was evaluated by objective criteria, as signs of use, trophique, vascularisation, mobility, sensibility and the integration of replants into general function of the hand, and on the other side by subjective criteria as usefulness in professional and private life, retrospective personal attitude to replantation and subjective complaints.

Adolescent↗
PubMed1977

[Qualitative analysis of the binding of fibrin in organic tissue (author's transl)].

The binding energy (EB) of oxygen, sulphur and nitrogen was determined in highly concentrated fibrin, collagen, liver parenchyma and muscle tissue using photoelectron spectrometry. Fibrin was mixed with the collagen, liver or muscle homogenisate, with or without substitution of clotting factor XIII or additional inhibiton of fibrinolysis and the EB was determined again. Changes in the binding energy arise from an alteration in chemical binding. The present investigation showed that fibrin builds up new linkages in liver parenchyma and in collagen using nitrogen bonds and, additionally via a sulphur bond. After addition of fibrin stabilizing factor a new chemical link appeared between fibrin and collagen again through a nitrogen bond and, additionally via a sulphur bond. The inhibition of fibrinolysis produced a new oxygen linkage in all the examined substances (fibrin-tissue).

Binding Sites↗
PubMed1977

[Experiences with a biological adhesive system (fibrin) in the dressing of kidney parenchymal wounds (animal experiment and 1st clinical experiences)].

We report on investigations describing the use of a biological adhesive system for tissue adhesion and local haemostasis. This system consists of highly concentrated native fibrinogen and thrombin. Clotting factor XIII is admitted for reinforcement of the fibrin network. In experimental partial kidney resection this system was used with excellent results. This experience led to successful application of this method in 15 patients who underwent partial nephrectomy for various diseases.

Animals↗
PubMed1977

[Light and electron microscopic study on the morphological changes in muscle fibers appearing after autologous muscle transplantation].

The extensor digitorum longus muscle of the rat was denervated and transplanted onto the vastus lateralis muscle of the same limb 1 or 2 weeks after denervation. The morphological changes appearing after transplantation were examined by light and electron microscopy. Only three to four superficial layers of muscle fibers remained unchanged after transplantation. The other parts of the transplanted muscle degenerated nearly entirely during the first 10 days. The myofibrils were removed by macrophages, thus within the tubes of basal lamina no contractile material could be observed. In a second period, regeneration of myofilaments took place. 6 weeks after transplantation, newly formed muscle could be observed, capable of normal function. The diameter of the fibres, however, was smaller and the connective tissue between the fibres markedly increased as compared to the normal muscle of the other side. The importance of the findings for muscle transplantation, especially the relationship between satellite cells and myoblasts, is discussed.

Animals↗
PubMed1977

[Failures and complications in vascular microsurgery].

Intraoperative and postoperative complications in the field of microvascular surgery are summarised. Some of them are discussed in detail (confusion of vessels, anastomosis under tension etc.), and precautions are outlined to avoid these complications. Failures can result from wrong indications, from incorrect technique of operation or from incorrect postoperative care.

Adult↗
PubMed1976

[Homologous articular cartilage transplantation in animal experiments. Preliminary studies on sheep (author's transl)].

Homologous articular cartilage without subchondral bone instead of the usual osteochondral grafts was transplanted in sheep. The transplants were fixed to the host by a biological tissue adhesive based on fibrinogen clotting. Light- and electronmicroscopic studies showed viable transplants up to 7 months and a stable bony union with the host through endochondral bone formation. A additional external fixation of the joint after transplantation or the use of a conventional cyanoacrylate tissue adhesive failed to achieve positive results. The relations of these preliminary findings for restorative techniques of articular cartilage defects are discussed.

Animals↗
PubMed1976

[The effect of anti-inflammatory substances on free muscle transplants in the experimental animal (author's transl)].

The effect of repeated subcutaneous injections of hydrocortisone and phenylbutazone on connective tissue formation was investigated in free rat muscle transplants. The follow-up investigation took place 4 weeks after transplantation of the long extensor muscles of the digits to the vastus lateralis group of the rectus femoris muscle. Connective tissue measurements were performed on the basis of hydroxyproline determinations. It was observed that in the untreated transplant there is twice as much connective tissue (expressed as a percentage) as in the same muscle remaining in situ. Hydrocortisone did not reduce the amount of connective tissue in the transplant. Phenylbutazone reduced the amount of connective tissue by 27%. At the same time the total weight of the transplants treated with hydrocortisone and phynylbutazone was reduced by 15% and 33% respectively. Attention is drawn to the myotoxic properties of hydrocortisone and phenylbutazone. Hence, in spite of the inhibited connective tissue formation there is no improvement in muscle fibre regeneration and their use cannot be recommended.

Animals↗
PubMed1976

On the diagnosis of minimal breast cancer in a screenee population.

As a result of screening of 8100 consecutive volunteers, 67 breast cancers have been detected. Fourteen percent of these cancers were found in women aged 35-44 years. Eighty percent of the cancers found in this age group were minimal breast cancer. This percentage decreased significantly in each subsequent decade until age 65 years, or older, when it began to rise once more. While mammography was responsible for detecting the majority of in situ or minimal cancers, 13 were found on physical examination, six of which were found only by physical examination.

Adult↗