Search PubMed⌕ Search

Biomedical subjects

J Holland

Publications and source records attributed to J Holland.

At least 163 records · Page 9Linked to original sources
PubMed1977

Suicide by fire: a contemporary method of political protest.

Suicide by fire (self-incineration)for the purpose of political protest has appeared in several countries during the previous decade. In this paper, the history of this form of suicide has been explored. The authors examined all cases of suicide by fire reported in the London Times and New York Times between 1790 and 1972. Seventy-one per cent of these reported suicides occurred during the most recent decade, 1963 to 1972, with all cases of political self-incineration occurring during this period. The socio-cultural context in which this form of protest may occur, and the psychological factors in individuals who choose this method of suicide are both discussed. It is suggested that the occurrence of self-incineration as a means of political protest may be yielding to more aggressive acts of terrorism as popular methods of forcing political change.

England↗
PubMed1976

The effect of dibromodulcitol on resting and dividing lymphoid cells.

The effect of dibromodulcitol (DBD) on the incorporation of labelled precursors into DNA and RNA fractions of PHA-stimulated human lymphocytes and of P388F lymphoma cells at various stages of their growth was studied. Both cell systems showed sensitivity to the drug within the concentration rage of 1-10 mug/ml. When DBD was added before phytohaemagglutinin (PHA), h.han RNA. In contrast, by adding DBD after PHA, RNA labelling was much more inhibited than DNA. In the latter case, the decrease in DNA labelling occurred only 24 h after drug treatment whereas RNA labelling was decreased 1 h after treatment. Levels of DBD which normally produced 30% inhibition in plating efficiency of P388F lymphoma cells affected uridine-5-T incorporation to a different extent at different stages of growth of the culture. Enhanced RNA labelling occurred in early exponential stage while at later stages of growth, RNA synthesis was depressed.

Adult↗
PubMed1976

Pharmacological evidence for stimulation of growth hormone secretion by a central noradrenergic system in dogs.

The role of brain catecholamines in the regulation of growth hormone secretion was investigated in pentobarbital-anesthetized dogs by using drugs which modify the function of adrenergic neurons and receptors. Intravenous administration of L-dopa produced a prompt, statistically significant increase in plasma growth hormone concentration. This response was not significantly reduced by blockade of peripheral dopa decarboxylase activity with carbidopa. Clonidine, an alpha-agonist which penetrates the brain, increased plasma growth hormone secretion. Norepinephrine, epinephrine, dopamine and isoproterenol, catecholamines which do not penetrate the blood-brain barrier, failed to affect plasma growth hormone concentration when administered intravenously. Apomorphine did not produce a statistically significant increase in plasma growth hormone concentration when administered directly into the the third ventricle, and pimozide failed to abolish the increase in plasma growth hormone produced by L-dopa. The increase in plasma growth hormone concentration produced by intravenous L-dopa and clonidine was prevented by administration of phentolamine or phenoxybenzamine directly into the third ventricle. The response to L-dopa was also abolished by intraventricular procaine. In dogs in which central beta-adrenergic blockade was produced by intraventricular L-propranolol, the growth hormone response to L-dopa was greater than it was in control dogs treated with intraventricular D-propranolol. The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the 'blood-brain barrier', and that the norepinephrine acts via alpha-adrenergic receptors.

Adrenergic alpha-Antagonists↗
PubMed1976

Effect of 60Co gamma-irradiation on the reaction of mixed disulphides of mercaptoethylguanidine with enzymes of rat-liver cytoplasm.

A theoretical assumption of Eldjarn and Pihl suggests that mixed disulphides formed by radioprotective aminothiols and protein SH-groups can be broken down by enzymes in the organism, and the native structure of the macromolecules restored. Irradiation should enhance this effect. In our experiments, mixed disulphides of mercaptoethylguanidine (MEG) and albumin/haemoglobin were split by the soluble enzyme fraction of rat-liver homogenate (cytosol). The liberation of the radioprotector MEG is brought about by small molecules; dialysed cytosol has no effect, nor has the suspension of particles of mitochondria. On irradiation with doses in the 0-1--5-0 Mrad range, the mixed disulphide bridge is stabilized and made more resistant to splitting. Increased resistance up to 700 per cent with albumin-MEG and 160 per cent with haemoglobin (Hb)-MEG mixed disulphide was observed compared with the unirradiated control.

Animals↗
PubMed1976

Workshop: manpower planning to meet needs.

Ms. Holland describes the building of a data base which can be updated and used to plan for manpower needs. She includes an analysis of the present work force, of the organizational structure and of the demand situation as well as productivity trends. Her skills inventory can be applied to a large variety of institutions.

Career Mobility↗