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Biomedical subjects

J Hoff

Publications and source records attributed to J Hoff.

At least 19 recordsLinked to original sources
PubMed1998

Strength and endurance of elite soccer players.

PURPOSE: The major purpose of the present study was to examine whether there exists a relationship between preseasonal physiological tests and performance results in the soccer league. Further, it investigated maximal oxygen uptake and maximal strength in proportion to body mass for soccer players. A secondary aim was to establish some normative data of Norwegian elite soccer players. METHODS: Two teams from the Norwegian elite soccer league participated in the study. RESULTS/CONCLUSION: The present study supports previous investigations indicating a positive relationship between maximal aerobic capacity, physical strength, and performance results in the elite soccer league. It is concluded that for soccer players, maximal oxygen uptake should be expressed in relation to body mass raised to the power of 0.75 and maximal strength in relation to body mass raised to the power of 0.67, when the aim is to evaluate maximal aerobic capacity when running and strength capacity among players with different body mass. Midfield players had significantly higher maximal oxygen uptake compared with defense players using the traditional expression, mL x kg(-1) x min(-1), while no significant differences were found expressing maximal oxygen uptake either absolutely (L x min[-1]) or in relation to body mass raised to the power of 0.75 (mL x kg[-0.75] x min[-1]) among players grouped by position. There was a significant correlation (r = 0.61, P < 0.01) between squat IRM and vertical jump height. Vertical jump heights for defense and forward players were significantly higher compared with midfield players. Mean results from the laboratory test were 63.7 mL x kg(-1) x min(-1) or 188.6 mL x kg[-0.75] x min(-1) for maximal oxygen uptake, 150 kg or 8.0 kg x mb(-0.67) for 90 degrees squats, 79.9 kg or 4.4 kg x mb(-0.67) for bench press. Mean values of vertical jump height were 54.9 cm.

Adult↗
PubMed1998

Comparison of right atrial and peripheral procainamide infusion levels in patients with spontaneous or induced atrial fibrillation.

As part of a new effort to develop an implantable drug infusion/pacing system to treat atrial fibrillation, this study examined the effects of rapid intracardiac procainamide infusion in humans with pacing-induced atrial fibrillation. Twenty patients with atrial fibrillation for > 5 minutes during an EP study received 500 mg of procainamide either via a peripheral venous infusion (n = 5) or directly in the right atrium (n = 15). Peak coronary sinus and femoral vein procainamide blood levels (mean +/- SEM) during 10, 5, and 3.3 minute central infusions were 17.0 +/- 4.1, 25.1 +/- 4.5, 45.6 +/- 5.1 and 11.3 +/- 3.2, 17.1 +/- 6.4, 18.7 +/- 5.0, respectively. In contrast, peak coronary sinus and femoral procainamide levels following the 5 minute intravenous infusion were 17.7 +/- 5.1 and 9.3 +/- 2.1. Changes in QT, QTc, QRS, and RI intervals were similar at each infusion rate. Systolic blood pressures (BP) decreased more with higher procainamide infusion rates but similar when comparing intravenous versus central drug administration at the same rate. The mean +/- SEM decreases in blood pressure with the 10, 5, and 3.3 min procainamide infusions were 12f5, 20f11, and 39f14, respectively. Conversion to sinus rhythm was not a primary endpoint given the often transient nature of acute atrial fibrillation in this setting. We conclude that significantly higher femoral vein and coronary sinus procainamide levels can be achieved by central rather than peripheral drug infusion. These data support that concept that rapid central infusion of anti-arrhythmic therapy can result in high intracardiac levels of antifibrillatory agents for the treatment of paroxysmal atrial fibrillation.

Adult↗
PubMed1998

Prognostic value of dipyridamole thallium-201 screening to minimize perioperative cardiac complications in diabetics undergoing kidney or kidney-pancreas transplantation.

To minimize perioperative cardiac events, we utilize a screening protocol consisting of intravenous dipyridamole thallium-201 myocardial imaging (DPT), with the selective use of coronary angiography based on the presence of reversible defect(s) on DPT test. A retrospective study was performed to determine the prognostic value of this protocol and to identify any clinical parameters predictive of an abnormal DPT test. To accomplish this, a detailed chart analysis of 176 consecutive kidney (n = 89) and kidney-pancreas (n = 87) transplant recipients who had undergone pretransplant DPT testing was performed. The results of the DPT test were interpreted as normal in 111, fixed defect in 15, and reversible defect(s) in 50 patients. Forty-two of the 50 patients with reversible defect(s) underwent coronary angiography. Twelve of the 27 patients with significant coronary artery disease (CAD, > 50% stenosis in one or more coronary arteries) underwent pretransplant revascularization and the remaining 15 were treated medically. Cardiac events (documented acute myocardial infarction or sudden cardiac death) within 6 wk of transplant were stratified by the results of this protocol. Also, various clinical parameters were compared between patients with normal and abnormal (fixed and reversible defect) DPT tests. Only one of the 111 (0.9%) transplant recipients with a normal DPT test had a perioperative cardiac event. None of the 15 (0%) patients with a fixed defect and none of the 15 (0%) patients with reversible defect(s), but a nonsignificant (< 50% narrowing) coronary angiogram, had a perioperative cardiac event. Three of the 27 (11.1%) patients with reversible defect(s) and significant disease on coronary angiography, who had undergone pre-transplant revascularization or were managed medically, had a perioperative coronary event. Of 14 recipients parameters analyzed, age > 50 yr was the only variable predictive of an abnormal DPT test. We conclude that the incidence of perioperative cardiac events in patients with a normal or fixed defect, or reversible defect(s) but a nonsignificant (< 50% narrowing) coronary angiogram is very low, indicating the high correlation of these findings on DPT and an uneventful (cardiac) post-transplant course. The incidence of perioperative cardiac complications amongst the high-risk transplant recipients with reversible defect(s) and significant CAD on coronary angiogram may be minimized by appropriate preoperative medical management or revascularization. None of the clinical variables except age > 50 yr was predictive of an abnormal DPT test.

Adult↗
PubMed1996

Coordination, the determinant of velocity specificity?

Initial strength gains were examined in the context of learning a new skill. Forty female volunteers were randomly assigned to one of four groups: a bench-press training group utilizing heavy loads in its training, a bench-press training group utilizing almost no load, an alternative training group using different exercises, or a control group that did not train. Training period was 6 wk, with three training sessions per week. Emphasis was put on keeping the coordination and muscular adaptation demands in the bench-press groups as invariant as possible. Bench-press training with a light or with a heavy weight was shown to be equally effective in improving the maximal velocity of contraction for a given absolute resistance. Mean velocity with loads of 0.37, 6.6, 16.6, and 20 kg improved by 21.1, 15.8, 16.9, and 19.5%, respectively. No significant differences in the percent improvement at the four different loads were apparent, indicating that no significant velocity-specific adaptations were present. The bench-press training group, utilizing heavy loads in its training, was the only group with improved one repetition maximum. Overall, findings point to the development of coordination as the determining factor in early velocity-specific strength gains.

Adaptation, Physiological↗
PubMed1995

[Gelatinous peritoneal disease].

Gelatinous degeneration of the peritoin is an unusual disorder which inevitably takes the surgeon by surprise during laparotomy. Three cases are reported. The diagnosis, pathogenesis, prognosis and possible therapies are discussed. The tumoral pathogenesis usually appears to be non-malignant and to originate in the ovaries or appendix. However, gelatinous degeneration of the peritoin must be viewed as a disease with attenuated malignancy. The pattern of development is slow, with repeated peritoneal recurrences. The survival time is long. Treatment is essentially surgical even when recurrences occur.

Adenocarcinoma, Mucinous↗
PubMed1994

Fluctuations in plasma levodopa and motor responses with liquid and tablet levodopa/carbidopa.

To evaluate the ability of orally administered liquid levodopa/carbidopa (LD/CD) to stabilize plasma levodopa levels and reduce motor response fluctuations in Parkinson's disease, five patients received LD/CD hourly, as standard tablets or as an aqueous solution on two separate days in a double-blind, placebo-controlled, cross-over design. Except for a slightly earlier peak plasma levodopa level, no significant advantage of the liquid formulation over tablet therapy was found. However, liquid LD/CD could be helpful in quickly resolving "off" states and by facilitating small dose adjustments that are not possible with tablets.

Administration, Oral↗
PubMed1994

Breast granuloma and C.R.S.T. syndrome.

One case of CRST syndrome with breast granuloma is presented. The presumed diagnosis were infectious or neoplastic diseases. High doses of corticosteroids led to improvement in breast nodules.

Breast Diseases↗
PubMed1994

[Value of cold-knife conization without hemostatic sutures].

Retractile scarring often occurs after conisation of the cervix uteri, concealing the new squamocolumnar junction. It has been suggested that healing quality is improved if haemostatic sutures are not used. We report here on 118 cold-knife conisations carried out without haemostatic sutures. On histological examination there were 3% microinvasive carcinomas, 87% high-grade and 10% low-grade dysplasias. The endocervical margin was positive or doubtful in 6% of cases (n = 7). Six of these patients underwent secondary procedures which produced specimens free of transformation. A new colposcopic examination was performed six months after the cone biopsy: the squamocolumnar junction was visible in 90% confirming the usefulness of the technique.

Biopsy↗
PubMed1993

[Anterolateral hysteropexy via abdominal approach. Results and indications. Apropos of a series of 92 patients].

Of the possible surgical techniques for the treatment of genito-urinary prolapses, abdominal suspension is reserved for young patients in whom retention of sexual function is desirable. Fixation to the sacral promontory is the reference method but has some contraindications. Anterolateral suspension of the uterine isthmus to the anterior superior iliac spines by a strip of non-absorbable mesh, as described by Kapandji, is then a good alternative. We report our results with this technique over an 8-year period in 92 patients. Mean follow-up was 5 years. There was no intraoperative mortality nor major complications. Anatomical results were satisfactory in 87% of cases at 5 years, with however 4 reoperations for total recurrent prolapse, of which one was posterior. Functional results showed two cases of deep dyspareunia and 12% post-operative stress urinary incontinence, of gradual onset. In conclusion, anterolateral hysteropexy associated with removal of the pouch of Douglas is a reliable procedure with no particular danger. It can be a good alternative to fixation to the sacram promontory when the latter is contraindicated or dangerous.

Adult↗
PubMed1992

Hypercalcemia and breast cancer related to parathormone-like secretion by liver metastases.

A premenopausal woman developed hypercalcemia 30 months after treatment for infiltrating breast cancer. After bone metastases had been excluded, primary hyperparathyroidism was suspected. A parathyroid adenoma was removed and histologically confirmed. Hypercalcemia, associated with low plasma phosphate and severely depressed plasma parathormone (PTH) levels, persisted. Further investigations showed liver metastases from the primary breast cancer and also secretion of a PTH-like substance. Antitumoral treatment was effective on the liver metastases and also normalized calcemia and the PTH-like substance, demonstrating the existence of a paraneoplastic syndrome related to the secretion of a PTH-like substance by disseminated liver metastases of primary breast cancer.

Breast Neoplasms↗
PubMed1992

[Malignant hypercalcemia after treatment of breast cancer].

A premenopausal woman developed hypercalcemia 30 months after treatment for infiltrating breast cancer. After bone metastases had been excluded, primary hyper parathyroidism was suspected. A parathyroid adenoma was removed and histologically confirmed. Hypercalcemia persisted, associated with low plasma phosphate and severely depressed plasma parathormone (PTH) levels. Further investigations showed liver metastases from the primary breast cancer and also secretion of a PTH-like substance. Anti-tumoral treatment was effective on the liver metastases and also normalized calcemia and the PTH-like substance, demonstrating the existence of a paraneoplastic syndrome related to the secretion of a PTH-like substance by disseminated liver metastases of primary breast cancer.

Breast Neoplasms↗
PubMed1990

Prognostic value of intravenous dipyridamole thallium imaging in patients with diabetes mellitus considered for renal transplantation.

Patients with diabetes and end-stage renal failure are known to have a high risk for cardiac morbidity and mortality associated with renal transplantation. The most efficient method to determine preoperative cardiac risk has not been established. To determine the effectiveness of intravenous dipyridamole thallium imaging in predicting cardiac events, 40 diabetic renal transplant candidates were studied preoperatively in a prospective trial. The study group consisted of 40 patients whose average age was 42 years (range 27 to 64); 34 (85%) were hypertensive and 21 (53%) were cigarette smokers. Cardiac history included chest pain in 6 patients and prior myocardial infarction in 3 patients. Dipyridamole thallium imaging showed reversible defects in 9 patients, fixed defects in 8 patients and normal scans in 23 patients. Dipyridamole thallium imaging was performed using 0.56 mg/kg of dipyridamole infused intravenously over 4 minutes. Cardiac events occurred only in patients with reversible thallium defects, of which there were 6. Of these 6 patients, 3 had cardiac events before transplantation and 3 had them in the early postoperative phase (within 6 weeks of surgery). Of 21 patients who underwent renal transplantation, 3 had cardiac events within 6 weeks of transplantation. The average duration of follow-up was 11 months (range 1 to 21). Thus, dipyridamole thallium imaging is an effective method of identifying renal transplant candidates likely to develop cardiac complications. Routine coronary angiography may not be necessary to screen all renal transplant candidates for coronary artery disease before surgery.

Adult↗