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Biomedical subjects

J Hirschberg

Publications and source records attributed to J Hirschberg.

At least 73 records · Page 4Linked to original sources
PubMed1980

Acoustic analysis of pathological cries, stridors and coughing sounds in infancy.

In the examination of respiratory pathological sound phenomena in infancy (pathological crying, stridor and coughing sounds), besides the subjective-auditive observations and traditional examination methods (X-ray, endoscopy), acoustic analysis, as a new branch of bioacoustics, may be of much help. The various pathological infant vocalizations originating from the air passageways are merely symptoms, but they may furnish important diagnostic clues. Approximately 200 recordings of pathological sound signals derived from 180 infants suffering from 40 different diseases or anomalies were analyzed by means of sound spectrography, the fundamental frequency meter, and rarely, the minimal-time-interval spectra technique. The acoustical evaluation of the sound phenomena are not only of scientific and documentative value; they are also of great help in diagnostics and prophylaxis, in the suitable choice of diagnostic tools and in education and further training, i.e. in the everyday work of the pediatric otolaryngologist.

Acoustics↗
PubMed1977

Effects of the mitotic cell-cycle mutation cdc4 on yeast meiosis.

The mitotic cell-cycle mutation cdc4 has been reported to block the initiation of nuclear DNA replication and the separation of spindle plaques after their replication. Meiosis in cdc4/cdc4 diploids is normal at the permissive temperature (25 degrees) and is arrested at the first division (one-nucleus stage) at the restrictive temperature (34 degrees or 36 degrees). Arrested cells at 34 degrees show a high degree of commitment to recombination (at least 50% of the controls) but no haploidization, while cells arrested at 36 degrees are not committed to recombination. Meiotic cells arrested at 34 degrees show a delayed and reduced synthesis of DNA (at most 40% of the control), at least half of which is probably mitochondrial. It is suggested that recombination commitment does not depend on the completion of nuclear premeiotic DNA replication in sporulation medium.--Transfer of cdc4/cdc4 cells to the restrictive temperature at the onset of sporulation produces a uniform phenotype of arrest at a 1-nucleus morphology. On the other hand, shifts of the meiotic cells to the restrictive temperature at later times produce two additional phenotypes of arrest, thus suggesting that the function of cdc4 is required at several points in meiosis (at least at three different times).

DNA Replication↗