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J Hildebrand

Publications and source records attributed to J Hildebrand.

152 records · Page 9Linked to original sources
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Coronary circulation and myocardial oxygen consumption after extracorporeal circulation and after cardioplegic arrest.

The influence of haemodilution or of blood perfusion on the coronary circulation, myocardial oxygen consumption and on haemodynamic parameters was examined in two comparable groups of patients with slight congenital acyanotic cardiac malformation without indications of myocardial damage. In a third group of patients similar data were collected before and after artificial cardiac arrest by cardioplegic solutions. No findings concerning this question could be found in the literature. Coronary circulation was measured by the argon-gas-technique of Bretschneider et al. A fall in haemoglobin of 4.8% caused by haemodilution resulted in the first group in an increase in the cardiac index of about 8% and an increase in the coronary circulation of about 100% over the initial value with a simultaneous decrease in the coronary resistance due to coronary dilatation and reduction in blood viscosity. The myocardial O2 consumption was raised in spite of an increase in the coronary-venous O2 saturation and a clear reduction in the AVD O2. In contrast, the patients in the blood perfusion group showed no change in the coronary circulation and coronary resistance although a decrease of the myocardial O2 consumption was observed. The cardiac index fell to about 16% in these patients. After cardioplegic cardiac arrest there was no significant reduction in myocardial blood flow except for a decrease of myocardial oxygen consumption of about 20% The results are discussed and cantra-indications of haemodilution perfusion and cardioplegic cardiac arrest mentioned.

Cardiac Output↗
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[Neurotoxicity of formyl leurosine. An experimental and clinical study (author's transl)].

Leg paralysis and wallerian degeneration of sciatic nerve fibres have been produced in rats by intraneural injection of 0.5, 1 or 5 microgram of vincristine (VCR) or formyl leurosine (FLR) dissolved in 5 microliter of saline. Nerve lesions were dose-related, and were similar for equal concentrations of the two drugs. Six patients received one to three 5-day courses of FLR. The total dose of FLR administered ranged from 15 to 131 mg (mean 83 mg). Clinical signs of peripheral neuropathy were absent in four patients, and limited to orthostatic hypotension in one case and transient depression of reflexes in another. Motor conduction velocities measured in four peripheral nerves, and muscle evoked potentials remained unchanged throughout the treatment in all patients.

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PubMedDate not supplied

[Neurotoxicity of formyl leurosine. An experimental and clinical study (author's transl)].

Leg paralysis and wallerian degeneration of sciatic nerve fibres have been produced in rats by intraneural injection of 0.5, 1 or 5 micrograms of vincristine (VCR) or formyl leurosine (FLR) dissolved in 5 microliters of saline. Nerve lesions were dose-related, and were similar for equal concentrations of the two drugs. Six patients received one to three 5-day courses of FLR. The total dose of FLR administered ranged from 15 to 131 mg (mean 83 mg). Clinical signs of peripheral neuropathy were absent in four patients, and limited to orthostatic hypotension in one case and transient depression of reflexes in another. Motor conduction velocities measured in four peripheral nerves, and muscle evoked potentials remained unchanged throughout the treatment in all patients.

Aged↗
PubMedDate not supplied

[Tremors].

Tremor (Tr) is an involuntary rhythmic movement disorder. Its causes are multifold. The physiopathogenesis is complex and only partially understood. The classification, based on clinical grounds distinguishes: 1) Physiological Tr at 8-12 Hz, postural, involving the limbs; 2) Essential Tr at 8 Hz, often familial, postural, involving the limbs; 3) Parkinsonian Tr at 4-6 Hz, present at rest, rarely isolated, often asymmetrical, involving the limbs, sometimes the jaw; 4) Cerebellar Tr at 3-4 Hz, maximal at the end of limb movements. Therapy is based on this classification. The main points for the diagnosis are age of onset, associated signs, toxic factors and heredity.

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