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Biomedical subjects

J Higginson

Publications and source records attributed to J Higginson.

99 records · Page 6Linked to original sources
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Importance of environmental and occupational factors in cancer.

Geographic and temporal variations in cancer incidence, changes in migrants, differences between males and females, as well as case history studies are discussed. Cancers of the workplace can be divided into those related to "point-source" industrial pollution and those where the social milieu or "life-style" of the occupation play a role (e.g., job-associated cancers). In the future, considerably more effort is necessary in studying the life-style factors in specific occupational settings. It is important not to forget that occupational cancer is essentially an excess risk over the background risks.

Behavior↗
PubMedDate not supplied

[Program of the International Center for Cancer Research: Epidemiological approach].

The development of the International Agency for Research on Cancer is discussed and its programme outlined. The programme of the Agency is largely directed to epidemiological studies which are co-ordinated with laboratory studies. The objective is to make use of geographical variations in cancer incidence as a means of identifying causative factors. The nature, and the difference between analytical and descriptive epidemiology, are discussed. The possible significance of industrial hazards in modern societies is reviewed. The epidemiological approach to the identification of the causation of cancer of the oesophagus and liver is summarized, as is also the possibility of applying epidemiological techniques to the study of host factors.

Carcinogens↗
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Discriminant analysis of biochemical parameters in liver disease.

Discriminant function analysis has been used to investigate the relative value of six biochemical parameters (plasma ferritin, C-reactive-protein, bilirubin, alkaline phosphatase, glutamic oxaloacetic acid transaminase and albumin) in the diagnosis of liver disease. This was done among four groups totalling 70 subjects including healthy controls and patients with acute viral hepatitis, liver cirrhosis and primary hepatocellular carcinoma. Albumin had most value in distinguishing between groups, followed cumulatively by ferritin, alkaline phosphatase, C-reactive protein, bilirubin and glutamic oxaloacetic acid transaminase. However, if data on albumin, alkaline phosphatase, bilirubin and glutamic oxaloacetic acid transaminase had already been routinely collected, there would be no advantage in collecting data on ferritin and C-reactive protein. Any four of the six parameters would be of about equal value in distinguishing between diagnostic groups. When the data on all six biochemical parameters was combined in an optimum way, about 66% of all individuals could be correctly assigned to one of the four groups using biochemical markers alone. While the control subjects and patients with acute viral hepatitis formed a relatively well defined, tight cluster (apart from two patients with acute viral hepatitis), patients with liver cirrhosis and primary hepatocellular carcinoma were almost indistinguishable, using these biochemical parameters. If the latter two groups were pooled, then about 86% of subjects could be correctly classified.

Alkaline Phosphatase↗