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Biomedical subjects

J Hickman

Publications and source records attributed to J Hickman.

At least 55 records · Page 3Linked to original sources
PubMed1977

Role of the carbohydrate moiety in determining the survival of interferon in the circulation.

The role of the carbohydrate moiety in influencing the survival time of human lymphoblastoid interferon in the rat circulation was monitored at varying time intervals after intravenous injection. The serum survival time of native interferon was drastically reduced by prior enzymatic cleavage of the terminal sialic acid residues to yield the galactose-terminal product, asialo-interferon. This phenomenon was completely reversed by further extensive digestion with a mixture of glycosidases which effectively removed over 85% of the total carbohydrate residues. These results suggest that the intact carbohydrate structure is neither essential for normal circulation time in vivo nor for biologic activity in vitro.

Animals↗
PubMed1977

The arterial supply of the navicular bone and its variations in navicular disease.

Macroscopic, microscopic and radiological examinations of the navicular bones of 83 horses and ponies showed that the navicular bone in the adult horse has 2 principal routes of blood supply. One supply is present at birth, the other develops within the first 2 to 3 years of life, in response to increasing activity. The size of the nutrient foramina, as seen on radiographs, is related to the type, frequency and regularity of work done by the horse. These foramina are normally conical in shape, alteration to a circular, or mushroom-shape being evidence of occlusive vascular disease in the navicular bone. These changes are visible on a standard antero-posterior radiograph of the navicular bone. A common cause of lameness in the horse is ischaemia of the navicular bone, due to progressive arterial occlusion. Occlusion of at least 2 primary arteries, and some involvement of the compensating collateral blood supply must be present before lameness results.

Animals↗
PubMed1976

The treatment of some fractures of the forelimb in the horse.

Sir Frederick Hobday's service as a Veterinary Officer in the Army Veterinary Corps during the Great War 1914-1918 is recorded. This is followed by a description of the fractures of the distal forelimb which can be treated satisfactorily by surgery, and includes fractures of the carpal, the small metacarpal, the proximal sesamoid bones, the first phalanx and the extensor process of the third phalanx.

Animals↗
PubMed1975

The treatment of horses with chronic back pain by resecting the summits of the impinging dorsal spinous processes.

This paper describes the surgical treatment of 14 horses exhibiting chronic back pain attributed to impaction and overriding of the dorsal spines in the thoracolumbar region. The technique involved the resection of the summits of one or more dorsal spines following midline division of the supraspinous ligament. All the horses returned to full work after a convalescent period of at least four months, and 12 of them showed considerable improvement in their form and performance. A post-surgical complication encountered in one case was the development of new bone on the edge of a resected spine. This lesion, which pressed on the dorsal spine immediately caudal to it, was removed subsequently at a second operation and no further sequelae occurred.

Animals↗