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Biomedical subjects

J Hetherington

Publications and source records attributed to J Hetherington.

At least 55 records · Page 3Linked to original sources
PubMed1980

Biostatistical analysis of the collaborative glaucoma study. I. Summary report of the risk factors for glaucomatous visual-field defects.

A prospective collaborative study was conducted in five centers during a 13-year period to identify factors that influence the development of visual-field defects (GVFDs) of open angle glaucoma. In 5,000 subjects, GVFDs developed in only 1.7% of eyes. Statistical analysis of 26 factors at first examination identified five that were significantly related to the development of GVFDs--outflow facility, age, applanation pressure, cup-disc ratio, and pressure change after water drinking. Their absolute initial value, and not its change with time, was the important predictor. Multivariate analysis showed their collective predictive power to be undesirably poor, indicating that other factors must play an important role in the development of GVFDs. Mortality-table analysis indicated that during a period of five years, 98.54% of eyes with initial pressure less than 20 mm Hg continued to be free from GVFDs as compared with 93.34% of those with pressure of 20 mm Hg or greater.

Aged↗
PubMed1979

Adverse effects experienced by patients taking timolol.

Adverse effects involving one or more organ systems occurred in 38 of 165 patients with various types of glaucoma when timolol was added to their glaucoma therapy. It was necessary to discontinue timolol because of these side effects in 15 (9%) of the patients. Double-masked studies will be necessary to clarify the relationship of these adverse effects to the use of timolol.

Aged↗
PubMed1977

Revision of filtration surgery.

Forty-one procedures were performed to revise malfunctioning filtering blebs in 37 eyes. Thirty-two procedures were undertaken on underfiltering blebs, seven on overfiltering blebs, and two on normally functioning but otherwise unsatisfactory blebs. Revision procedures were successful in 24 of 32 underfiltering blebs, four of seven overfiltering blebs, and one of two normally functioning but unsatisfactory blebs.

Adult↗
PubMed1976

Glaucomatous cupping of the optic disk by ultrasonography.

B-scan ultrasonography was used to evaluate advance glaucomatous cupping of the optic disk (0.7 cup/disk ratio or greater) in one normal subject and six patients with glaucoma. The normal eye emitted a continuous echo from the posterior pole, which conformed to its mild degree of concavity. The glaucomatous eyes emitted echos from the posterior pole, demonstrating the more extreme concavity of the optic cup. Ultrasonographic evaluation of an acrylic plate containing holes of known diameter demonstrated the limits of resolution and artifacts that resulted from this examination.

Glaucoma↗
PubMedDate not supplied

Goniotomy vs trabeculotomy.

Goniotomy is a safe effective procedure in isolated trabeculodysgenesis occurring in children under the age of two years, and is preferred by the authors in all such cases when visibility allows. It may also be effective for varying periods of time in Sturge-Weber syndrome, Aniridia, Axenfeld's syndrome, and Lowe's syndrome when these occur in infancy. Trabeculotomy is generally preferred in children with trabeculodysgenesis over the age of three years, in situations where corneal clouding prevents adequate visualization of the trabecular meshwork, and in patients with aniridia. In the latter group, although goniotomy can be effective, its success rate is low. The absence of iris covering the lens does increase the risk of lenticular injury and, therefore, trabeculotomy is usually chosen.

Adult↗