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J Henry-Suchet

Publications and source records attributed to J Henry-Suchet.

At least 37 records · Page 2Linked to original sources
PubMed1994

[A new therapeutic strategy using a ofloxacin-amoxicillin-clavulanic acid combination in the treatment of upper gynecologic infections. Apropos of 123 cases].

OBJECTIVE: To evaluate a new antibiotic strategy with a combination of ofloxacin + co-amoxiclav in the treatment of pelvic infectious diseases. DESIGN: An open-non-comparative multicentre (10) study. SUBJECTS: 123 patients (118 salpingitis and 5 endometritis) were included clinical, laparoscopic and bacteriological assessments were performed before treatment and a laparoscopic control was done in 35% of cases. Among positive bacteriological samples before treatment 48.7% C. trachomatis were isolated; 56.1% of salpingitis were considered as severe (COGIT score > 6). TREATMENT: Patients received at entry oral ofloxacin 200 mg bid in combination with parenteral co-amoxiclav 2 to 4 g following by oral route. Total duration of treatment was 21 days. RESULTS: With respectively 97.2% and 91.6% satisfactory clinical and bacteriological results, this combination should take a major place in the treatment of pelvic infectious diseases.

Adolescent↗
PubMed1993

[Clinical and colposcopic aspects of bacterial vaginosis].

Bacterial vaginosis is characterized by an uniform, malodorous, white-grey discharge. The presenting symptom is generally the unpleasant smell of the vaginal discharge, particularly following the menses or intercourse. Other functional signs, such as pruritus, dysuria and dyspareunia are rare. Inflammatory signs are frequent, and can be revealed by colposcopy with the Lugol test: this shows punctuate colpitis with small regular points corresponding histologically to an inflammatory focus in the connective tissue. The term "vaginitis" is avoided because of the absence of polymorphonuclear cells in the vaginal discharge, despite the presence of inflammation. Bacterial vaginosis has been held responsible for prematurity, small birthweight and post-partum infection. Nonetheless, Gardnerella vaginalis and Mobiluncus spp can be recovered from the vaginal flora of women with no signs of inflammation.

Animals↗
PubMed1992

[Synergic effect of Dextran 70 at 32% and an antibiotic in the prevention of peritoneal adhesions. Experimental study in rats].

In an experimental study we evaluate the anti-adherential effect of four different solutions: physiological serum, Chloramphenicol, Dextran 70 (32%) and the association of these last two solutions. Synergic effect is shown when using an antibiotic (Chloramphenicol) with a non-bactericid solution (Dextran). Comparing our results with current literature, we are confident on the efficacity of similar association concerning other solutions than Dextran 70 (32%).

Animals↗
PubMed1990

[Contraception and tubal sterility of infective origin].

A series of 89 caucasian women, who had been operated on for non-infectious tubal infertility were studied to find out what contraceptive methods they had used before they became infertile (oral contraception, intra-uterine contraceptive device and other methods). A matched series of 178 fertile women were used as a control group. The numbers who had chlamydia were studied as a function of the method of contraception in the group of infertile women. This work shows that women with tubal infertility due originally to infection had less often used oral contraception than the matched group of fertile women had. One can conclude that oral contraception acts as a prevention against this cause of infertility. The role played by intra-uterine contraceptive devices is difficult to establish. All the same, there is a significant relationship between the use of intra-uterine devices and tubal infertility of infectious origin, whether we look at multiparae or women between 25 and 34 years of age. This study also shows that chlamydia is not associated with the use of combined preparation oral contraceptives, nor with the use of the intra-uterine device in women who have tubal factor infertility. This study all the same shows that it does seem to be important to advise oral contraception in preference to the intra-uterine device in women who are still wanting to have a pregnancy, even if they are multiparae or multigravidae.

Adult↗
PubMed1989

[Statistical study of the factors influencing the prognosis in tuboplasty operations. Importance of the status of the ampullary mucosa and of chlamydial infection].

In a consecutive series of 508 tuboplasty operations, the actuarial figures for pregnancy after 2 years was 74% for proximal sutures, 27% for repeat terminal plastic operations and 42% for primary terminal plastic operations. A statistical study of the factors influencing these results was carried out with a multivariate analysis. This showed what factors determine the results. Some of these were already known (such as the extent of the tubal lesions, the state of the ampullary mucosa and the degree of adhesions); and the importance of active chlamydial infection was confirmed by the finding of positive pelvic cultures. These reduced significantly the levels of success even in anatomically favourable cases where the tubes were not completely blocked (24% if the cultures were positive and 64% if the cultures were negative, P less than 0.001) and if the ampullary mucosa was normal on salpingoscopy (21.6% successes if the cultures were positive and 64% if negative, P less than 0.001). A therapeutic strategy should be worked out for any operation in order to 1) select the best cases and 2) eradicate C. trachomatis before surgery.

Adult↗
PubMed1988

[The role of Chlamydia trachomatis in the infectious etiology of extra-uterine pregnancy].

The study was carried out in two different hospital centres on a series of 55 women who had ectopic pregnancies compared with 2 control groups. The study concerned taking samples from cells in the pelvis to culture for Chlamydia trachomatis and to estimate the levels of anti-Chlamydia antibodies. The cultures were positive in 30% of the cases and the serology was positive in 52% of the cases. This difference is significant when compared with the control groups (p less than 0.001). There was no significant statistical difference as far as positive cultures were concerned between the groups of women who had or had not had previous tubal infertility or a history of salpingitis. It seems that Chlamydia trachomatis can itself therefore be a direct cause for the development of an ectopic pregnancy.

Abortion, Spontaneous↗
PubMed1987

Microbiologic study of chronic inflammation associated with tubal factor infertility: role of Chlamydia trachomatis.

One hundred sixty-one women undergoing laparoscopy for infertility of obstructive origin (fallopian tube stenosis or obstruction and periadnexal adhesions) had thorough bacteriologic studies, including Chlamydia trachomatis cultures, of their lower and upper genital tracts. Peritoneal or tubal fluid cytologic features and biopsies of fallopian tubes or adhesions were also studied after each laparoscopy. The serum of each woman was titrated for evidence of C. trachomatis infection. The sera of a control group of 51 women with ovarian infertility but normal fallopian tubes according to laparoscopy and hysterosalpingogram were titrated in an identical manner. The current study confirms previous studies that showed a strong correlation between infertility due to fallopian tube factors and positive C. trachomatis cultures or serologic studies. The current study suggests that C. trachomatis infection does not correlate with a past history of salpingitis or pelvic pain, but that current C. trachomatis infection, as assessed by positive culture, does correlate with gross and histologic evidence of chronic inflammation.

Adult↗
PubMed1987

[Treatment of acute salpingitis with a combination of augmentin and synthetic tetracycline or augmentin alone].

UNLABELLED: 41 cases of acute salpingitis were treated: either with the combination Augmentin + Tetracycline (A + T) including 21 severe cases treated intravenously for 4 days, then per os and 10 moderate cases treated per os from the beginning-or by Augmentin alone (A) per os for 10 other moderate cases. An accurate bacteriological diagnosis was made before treatment and, in case of failure, most often by celioscopy. A Chlamydia serology was performed. Patients were seen again after 8 days (41 cases), one month (39 cases) and several months (32 cases). RESULTS: A Chlamydia infection was found responsible, by culture or serology, in one out of 2 cases; only one germ was found in 14 cases, 2 germs in 21 cases and none in 7 cases. The association A + T was effective in all moderate cases at 8 and 30 days; in severe forms, there was a failure at 8 days and 4 others at 30 days or 17%. Augmentin alone per os caused 5 failures out of 10 cases at 8 days. No new failure was observed after several months in cases cured at 30 days. The association A + T may be recommended as very effective in moderate forms of acute salpingitis.

Acute Disease↗
PubMed1986

Evaluation of doxycycline in the treatment of chlamydial salpingitis.

Acute salpingitis caused by Chlamydia trachomatis and other associated pathogens was diagnosed in 55 patients by means of laparoscopy and serological tests. All patients were treated with intravenous injections of doxycycline (200 mg/day) for four days followed by the same dosage orally for 20 days. Other antibiotics were given concomitantly for the associated infections. Treatment efficacy was evaluated on day 7 and day 30. Clinical symptoms had disappeared in 45 (82%) of the patients, and improvement was seen in another four (11%). Failure to improve in six cases was attributed to concurrent infection with microorganisms other than C trachomatis. After 30 days of treatment, two infections attributed to C trachomatis had not been cured with the doxycycline treatment; one of the patients was believed to have been reinfected and the other did not follow the prescribed treatment. The finding of clinical failure due to associated infection, sometimes discovered after two or three weeks of treatment, necessitates treatment of chlamydial salpingitis with multiple antibiotics, subsequent follow-up procedures (laparoscopic and serological), and appropriate changes in antibiotic therapy after C trachomatis has been eradicated but other pathogens remain.

Adult↗
PubMed1986

[The value of an antiprogesterone steroid in the treatment of extra-uterine pregnancy. Preliminary results].

The aim of this work is to study the effects of an antiprogesterone drug (RU 486) on extrauterine pregnancy and to draw from it possible inferences for therapy. The study was carried out on 28 patients presenting an extrauterine pregnancy, the levels of plasma chorionic gonadotrophins of whom were higher than or equal to 250 mIU/ml. Different modes of administration were employed and a coelioscopic salpingotomy was carried out for a pathological study.

Abortifacient Agents↗
PubMed1985

[Tuboscopy].

Tuboscopy permits the observation of the tubal mucosa and the discernment of two types of lesions: synechiae and mucosal "plates". The coincidence of the interpretation of hysterography and the results of tuboscopy does not exceed 1 case in 2. Experience shows that intrauterine pregnancies which develop beyond the first trimester only survive when tuboscopy shows us a normal mucosa, whatever may be the salpingographic picture. It is better to abandon the idea of a plasty when the tubal mucosa is in a bad condition.

Endoscopy↗