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Biomedical subjects

J Hemet

Publications and source records attributed to J Hemet.

144 records · Page 8Linked to original sources
PubMedDate not supplied

[Information obtained by liver biopsy in 100 tuberculous patients].

The results of liver biopsy in 100 patients with tuberculosis are reported. In 8 patients, biopsy only occurred secondarily, during liver disease which appeared during antituberculous treatment. In five cases, the association of rifamycin and isoniazid was probably responsible and the mild histological signs noted suggested a favourable course after stopping one of the drugs or simply reducing the dose. The 3 other patients had virus hepatitis and biopsy was of prognostic interest by revealing the onset of post-hepatic cirrhosis. In 92 cases, liver biopsy was carried out before treatment. In 34 cases the liver was normal, in 38 patients there were hisotlogical changes which did not suggest tuberculosis but, probably, alcoholism. These were : steatosis, in 21 cases, cirrhosis in 8 cases, a mixture of steatosis and cirrhosis in 4 cases, and acute alcoholic hepatitis in 5 cases. Finally, in 20 cases, biopsy revealed an appearance of granulomatous hepatitis. Although this lesion is significant in the development of the disease, it is not characteristic of tuberculosis unless there is caseous necrosis, as in 2 cases, and unless culture of the biopsy material is positive, as in one case out of 9, i.e. the diagnostic interest of liver biopsy is not very great compared with prognostic interest. By determining the anatomical condition of the liver, often not obvious when simple liver function tests are carried out, it permits one to forsee to some extent the tolerance of the liver to antituberculous treatment, especially in alcoholics.

Alcoholism↗
PubMedDate not supplied

[Flow cytometry of polypoid neoplasms of the colon resected by endoscopy].

Sixty-one neoplastic polypoid lesions of the large bowel and rectum, obtained by endoscopic resection, were submitted to cytofluorometric measurements. This study was performed on archival formalin fixed and paraffin embedded material using the method of Hedley. Coefficient of variation, DNA Index, DNA aneuploidy, proliferative activity were statistically correlated to histological grading (according to U.I.C.C.) and to the presence of trophic changes (epithelial displacement, hemorrhage, mucus discharge. Compared with morphological findings, cytofluorometric results revealed that DNA aneuploidy appeared only when intraepithelial carcinomatous changes were present, and was found in 50 percent of microinvasive carcinoma. The proliferative activity was significantly increased in intraepithelial carcinomas, with a significant enlargement of the coefficient of variation. This change may reflect initial disorders in DNA content of neoplastic cells. On the other hand, there was no significant difference between lesions with and without trophic alterations. These findings confirm that this increase is an independent phenomenon during tumor progression.

Adenocarcinoma↗
PubMedDate not supplied

[Hepatitis due to pirprofen; 3 cases, 1 fatality].

We report three cases of jaundice in women taking 800 mg pirprofen.day-1 during 6 weeks to 4 months and a half. Two of them presented cutaneous side effects: one case was rapidly better with corticosteroids. Fatal case possibility incite to transaminase surveillance.

Aged↗
PubMedDate not supplied

[Anorectal stenosis caused by suppositories of dextropropoxyphene and paracetamol (Diantalvic)].

Occasionally, administration of medical substances per annum may result in serious local lesions. The authors report the case of a 58 year-old woman presenting ulcerative and stenosing lesions of the anal canal which led to abdominoperineal resection. History revealed the administration of two suppositories daily, each containing an association of dextropropoxyphene and paracetamol, during seven years because of a cervical pain. Fourteen similar cases have been found in the literature, underlining the difficulties in clinical and pathological diagnosis. The exact mechanism of these lesions remains unknown.

Acetaminophen↗
PubMedDate not supplied

[The endometrium under the effects of hormone replacement therapy in menopause with percutaneous estradiol and low-dose micronized progesterone].

AIM: The aim of our study is to evaluate the effects of a new combined association of percutaneous estradiol with oral micronized progesterone during 25 days/month and to confirm that a low dose of progesterone (100 mg/day) can adequately counteract endometrial proliferation induced by estradiol. METHODS: 78 endometrial tissue samples were obtained in a multicenter study on the effects of hormonal replacement therapy of the menopause. Endometrial biopsies were performed on average at the 6.6 month of the hormonal substitution (range: 5-13 months) after 12 days minimum exposure to progesterone. The morphological evaluation was performed blindly. RESULTS: All endometria are only slightly developed, without hyperplasia. Four groups were individualized: subatrophic endometrium (3), quiescent endometrium (48), slightly active endometrium (18), and endometrium with marginal secretion (6). Rare mitosis images have only been found in slightly active endometria. Their number is always very much below the normal proliferative phase with only 3 cases between less than 3 and 6 mitoses per 1000 glandular epithelial cells. CONCLUSION: A low micronized progesterone dose (100 mg/day) over a long period (25 days per month) allows to efficiently control the estrogen-induced endometrial proliferation. This adequate endometrial response is responsible for a high incidence of amenorrhea, often asked by patients, and for rare spottings.

Administration, Cutaneous↗