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Biomedical subjects

J Helm

Publications and source records attributed to J Helm.

36 records · Page 2Linked to original sources
PubMed1993

Cloning and restriction fragment length polymorphism analysis of a cDNA for swine PIT-1, a gene controlling growth hormone expression.

A partial swine cDNA which encodes the functional domain of PIT-1 was isolated by the polymerase chain reaction (PCR). The swine PIT-1 cDNA clone is 95% identical at the protein level to the rat Pit-1 gene. Thus, Pit-1's known function in control of rat growth hormone and prolactin expression is likely to be conserved in swine. This swine cDNA clone was used to investigate genetic variability at PIT-1 in several American and Chinese breeds. Polymorphic BamHI fragments were found in pure-bred Meishan animals (n = 13), but only monomorphic fragments in five American breeds (n = 36).

Amino Acid Sequence↗
PubMed1988

Nonfunctioning islet cell carcinoma of the pancreas. Complete response to continuous 5-fluorouracil infusion.

An unresectable, intraabdominal recurrence of a nonfunctioning islet cell carcinoma of the pancreas developed in a 56-year-old man 9 years after he achieved complete remission from extensive radiotherapy. Chronic renal failure secondary to radiation nephritis precluded the use of streptozotocin. 5-fluorouracil (5-FU) (300 mg/m2 per day) was given as a continuous, systemic infusion through a chronic indwelling central venous catheter for 1 year's duration. Treatment resulted in the prompt disappearance of all signs and symptoms of cancer, and computed tomography (CT) of the abdomen documented complete response. The patient continues in complete clinical remission 16 months after 5-FU was stopped. Continuous 5-FU infusion may be a potentially efficacious and less toxic alternative to streptozotocin in the treatment of islet cell carcinoma. Further clinical evaluation will be necessary to define its overall role in the management of these patients.

Adenoma, Islet Cell↗
PubMed1984

[Areas of use of patient-centered actions].

Various forms of patient-centered actions (acceptive listening, paraphrasing, verbalisation of emotional experience), their effects and their possible modes of action are described. The importance of the verbal encoding of prereflexive experience for counselling is dealt with at some length because it generally receives too little attention. The interview and counselling, which are special forms of patient-centered activity, are used as examples to show that patient-centered techniques should be varied to suit the purpose of concrete interactions and therapy sessions.

Affect↗
PubMed1981

[Evolving trends in verbal psychotherapy].

The present, still unsatisfactory level of theoretical reflexion in the field of verbal psychotherapy as well as the efforts made for an optimisation of the disturbance- and patient-specific method has led to three positions, which can be considered as developmental trends in verbal psychotherapy: traditional conceptions, endeavours for the extension of the basic behaviour, and integrative concepts. These different viewpoints have been problemised. It is to be hoped that the further development of verbal psychotherapy, owing to a deepened understanding of its modes of action and a further clearing up of the question of indications, will proceed more theoretically founded than it has until now.

Person-Centered Psychotherapy↗
PubMed1976

Intestinal propulsion in the dog. Its relation to food intake and the migratory myoelectric complex.

We studied electrical events and flow in the canine small intestine in vivo. The transit of a small radioactive bolus injected into the jejunum was monitored by counting from a Biebl loop. After feeding, the rate of propulsion of the bolus varied within a narrow range. When food and water were withheld for more than 12 hr, transit of the bolus hecame highly variable. The variability increased at about the same time as the onset of the migratory myoelectric complex associated with fasting. Electrical recordings from the intestinal muscle demonstrated that the bolus was propelled into the loop in advance of the band of intense spike potentials which travels along the small intestine in the fasted state. The bolus was cleared from the loop when the spike potentials reached this segment. Variability of transit after prolonged fasting can be explained by (1) variability in the rate of migration of the phase of intense spike potentials, and (2) the timing of the injection of the bolus in relation to the component phases of the electrical complex. Flow is highly dependent upon the electrical activity and the resulting contraction patterns of the small intestine, which are themselves dependent upon feeding.

Animals↗
PubMed1968

[Not Available].

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Bibliographies as Topic↗