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Biomedical subjects

J Heim

Publications and source records attributed to J Heim.

107 records · Page 6Linked to original sources
PubMedDate not supplied

[Serum thyroid hormones and TSH response to TRH during treatment of Graves' disease by carbimazole (author's transl)].

Serum concentrations of Thyroxine (T4), triiodothyronine (T3) free thyroxine index (F.T.I.) and TSH response to TRH were evaluated in 55 Graves' diseases treated by Carbimazole. There is a good correlation between serum thyroid hormones and clinical state: 83,7% for T4; 79,5% for T3; on the other hand there is a discrepancy between T3 and T4 in many cases and between delta TSH and T4 (47%) or T3 (46%). The decrease of T4 occurs before that of T3: 46,6% normal at the 4th month and 72,5% at the 9th month for T4 against 41% and 50% for T3. At the end of the treatment 96,4% of patients are clinically normal but 20% of them remain with T3 and T4 values above normal.

Carbimazole↗
PubMedDate not supplied

[Continuous recording of plasma glucose level after glucose tolerance and 3 different breakfast. Search for a normal post-prandial plasma glucose (author's transl)].

We have studied glucose tolerance test (GTT) and glucose after 3 different breakfast (50, 100, 150 g CHO), in order to define a postprandial glucose level for the detection and control of diabetes mellitus. If the breakfast is sufficient enough (100 or 150 g CHO) the response after breakfast is similar to GTT. The post meal glucose is < 1,5 g/L mean + 2 SD) at 35 mn and < 0,97 g/L at 108 mn. Glucose level over these limits set to search a diabetes. Nevertheless this study is restricted by two points: the subjects are young and the load must be sufficient enough (over 100 g CHO).

Adult↗
PubMedDate not supplied

[Ketoacidosis with false hyponatremia and important hyperchylomicronemia (author's transl)].

The ketoacidosis coma is described with plasma lipids at 270 g/l and hyperchylomicronemia. That is completed by a xanthomatosis rash and false hyponatremia (91 mEq/L). This fact is important because the prognosis is better than hyponatremia of ketoacidosis, after treatment evolution is good. Nevertheless because of the non-cooperation of the patient, sucrose level and HBA are high, and triglycerides are still elevated, but of type IV henceforth.

Adolescent↗
PubMedDate not supplied

[Effects of chronic administration of lithium on thyroxine (T4), triiodothyronine (T3), reverse T3 (rT3) free thyroxine ratio (FTR) and thyreostimuline (TSH) in thyrotoxicosis (author's transl)].

Fourteen hyperthyroid subjects were studied between 3 and 141 days. The reduction of thyrotoxicosis is rarely obtained (2 cases), mainly because on the one hand, correct plasma lithium level (0.7-1.2 mEq/L) is rarely obtained (3 cases only), on the other hand because a high dose of lithium is required, perhaps owing to high clearance of lithium in thyrotoxicosis. The indications of lithium use in thyrotoxicosis are reviewed.

Adult↗
PubMedDate not supplied

[Thyroiditis : diagnostic and therapeutic features (excluding Graves disease and myxedema) : 13 case-reports (author's transl)].

The incidence of De Quervain's thyroiditis is probably underestimated, since a radioiodine uptake study is not performed in all cases. An isolated cold nodule can reveal Hashimoto's thyroiditis. In other cases, the diagnosis is suggested by otalgia and positive tests for antimicrosomial antibodies. Surgery is often necessary because of the possible association with cancer ; the procedure should be extensive since spontaneously the outcome is often thyroid insufficiency.

Adult↗
PubMedDate not supplied

[HLA DRW3 and Graves' disease (author's transl)].

HLA A, B, C antigens were studied in 86 caucasians with Graves' disease, using the lymphocytotoxicity microtechnique. Results were compared to those obtained in 336 healthy controls. HLA DR antigens were studied by the technique of microlymphocytotoxicity after long incubation and results compared to those of 100 healthy controls. There is an increased incidence of DRW3: 51.6% as compared to 20% in controls with a high degree of statistical significance pc less than 0,0003. There is also an increased incidence of B8: 44,19% in Graves' disease against 22,47% in controls pc less than 0,001. These results agree with the conclusions of two recent studies where the incidence of DW3 analyzed by a lymphocytic mixed culture was greater than incidence of the B8 antigen.

Female↗