[Congenital myxedema with goiter caused by hormonogenesis disturbance].
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Biomedical subjects
Publications and source records attributed to J Hazard.
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The lecture given by P. Brocq on "The Hotel-Dieu from August 19th to 27th 1944" and P. Canlorbe's doctoral dissertaion on "The Medical Services in the French Resistance" have not received the attention they deserve. I was present at the Hotel-Dieu during that period and I wish to pay a just tribute to the personnel of the Paris hospitals. Historical events such as the beginning of the insurrection in the Police Headquarters on Saturday August 19th and the reaction of the German troups still in Paris are presented in this paper, along with some medical data, the rapid organization of a complete surgical unit similar to those deployed in wartime, including fearless volunteers who picked up casualties and dispatched them to the appropriate treatment centres composed of eight surgical teams. A message of hope was dropped over the Police Headquarters at around 6 p.m. on Thursday August 24th, more than five hours before Captain Dronne's detachment reached the Hotel-de-Ville and Place Notre-Dame. On Friday August 25th, the tactical group led by Colonel P. Billotte was triumphally acclaimed when it reached the wide space in front of the church. The number of casualties indicates how fierce was the confrontation: 822 wounded (398 Frenchs and 424 Germans) were admitted to the Hotel-Dieu, of which 283 died (78 French and 205 Germans). In the other Paris hospitals of the Assistance Publique, 3,083 patients were admitted for wounds and 567 died. The personnel of those hospitals was extremely performing during this period and also paid a heavy tribute. Three members of the Hotel-Dieu died and 10 were killed at the Bichat Hospital during the Lufwaffe air raid during the night of August 26-27th 1994. Time has come, more than fifty-three years later, to commemorate the courage of the personnel of those hospitals who effectively and generously fulfilled their mission during Paris Liberation.
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Systematic studies of blood glucose regulation have been performed in 103 cases of adult acquired hypothyroïdism. The results were the following: 11 cases of overt diabetes were discovered. The diagnostic was made when fasting blood glucose was superior to 120 mg/100 ml and glucosuria was present. 22 cases of asymptomatic (chemical) diabetes. The diagnosis was based on the abnormalities of the oral glucose tolerance test (OGTT). The criteria were those of Fajans and Conn. In 70 cases the results were normal. The comparison of these results with these obtained in a matched population of normal subjects did not show significative differences. Particularly the proportion of "flat curves" during the OGTT were not higher in cases of hypothyroïdism. Plasma insulin levels were determined in 20 cases of hypothyroïdism during OGTT. The results were the same as in non-hypothyroïd subjects. The abnormalities of glucose regulation observed in hypothyroïdism were not related to sex, age, overweight or cause of the disease. The number of diabetic patients is not significatively more important in cases of hypothyroïdism of immunological origin (especially Hashimoto's disease.
To specify the influence of blood pressure on diabetic microangiopathy, the factors related to retinopathy and nephropathy were studied among 56 consecutive type 1 (insulin-dependent) diabetic out-patients without hypertension. Diabetes mellitus had been diagnosed for at least one year (mean duration of diabetes +/- SEM = 11.4 +/- 0.9 years). Diabetic patients did not take any treatment liable to influence blood pressure. Clinical parameters, including blood pressure, tobacco and alcohol consumption, were recorded by the same investigator. Retinopathy was defined as more than 5 microaneurysms on a fluorescein angiogram, clinical and incipient nephropathy as an albumin excretion rate over than 300 mg/d and between 30 and 300 mg/d, respectively. On average, retinopathy (n = 25) was associated with longer duration of diabetes (16.5 +/- 1.2 vs 7.4 +/- 0.9 years; p less than 0.001) and higher systolic blood pressure (136.2 +/- 4.1 vs 126.3 +/- 2.8 mm Hg; p less than 0.05). Clinical (n = 9) and incipient (n = 23) nephropathies were associated with duration of diabetes (17.9 +/- 2.0 and 11.8 +/- 1.7 vs 8.7 +/- 1.6 years, respectively; p less than 0.01), and with systolic (145.0 +/- 7.9, 132.7 +/- 4.7 vs 123.5 +/- 4.2 mm Hg; p less than 0.01) and diastolic blood pressure (83.3 +/- 6.2, 77.3 +/- 3.2 vs 72.2 +/- 3.4 mm Hg; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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