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Biomedical subjects

J Havelka

Publications and source records attributed to J Havelka.

At least 73 records · Page 4Linked to original sources
PubMed1976

The influence of thyroid function on the diabetogenic action of triamcinolone in man. Glucose, insulin and growth hormone patterns after on oral glucose load.

In subjects with varying thyroid function (12 hypothyroid, 11 euthyroid and 12 hyperthyroid) an oral glucose tolerance test was performed without sensitization (OGTT) and after sensitizing with triamcinolone (TGTT). The blood glucose, serum immunoreactive insulin (IRI) and growth hormone (HGH) levels were assessed. In hypothyroid subjects a marked deterioration of the glucose tolerance was found during the TGTT as compared with OGTT, a reduction of the glucose disappearance index (GDI) and almost unchanged IRI values. The decrease of insulinogenic index (II) was not significant. In euthyroid subjects the decrease of glucose tolerance after triamcinolone was only mild, GDI values remained unaltered, IRI values and II increased. In hyperthyroid persons the decrease of glucose tolerance during TGTT was even less pronounced than in the euthyroid group, although the IRI value increased only on fasting. No significant differences of HGH pattern were observed in any group. In our patients the diabetogenic effect of triamcinolone was inversely related to the saturation with thyroid hormones and an increased response of insulin to glucose load was observed only in euthyroidism. In hyperthyroidism the participation of non-insular factors in the mechanism of maintaining the glucose tolerance after triamcinolone should be assumed.

Adult↗
PubMed1976

Diabetogenic effect of triamcinolone in man with impaired thyroid function: serum free fatty acids, inorganic phosphorus, calcium and total protein pattern after an oral glucose load.

In a group of 35 subjects (12 hypothyroid, 11 euthyroid and 12 hyperthyroid) the changes of FFA, inorganic phosphorus, calcium and total proteins were investigated during glucose tolerance test with (TGTT) or without (OGTT) triamcinolone pretreatment. In hypothyroidism the decrease of FFA during TGTT was blunted, whereas the pattern of phosphatemia was unaltered and total proteins were increased. In euthyroidism triamcinolone exerts the opposite effect on the behaviour of FFA (decline was smaller and shorter) and phosphatemia (decline was pronounced and persists for longer period). In hyperthyroidism the fasting level of FFA decreased in TGTT but during the test no significant differences in FFA and phosphatemia patterns were observed. The calcemia was not influenced by triamcinolone in any subgroup. Our results suggest the importance of thyroid function as modifying factor in some metabolic effects of triamcinolone in man. Changes in hypothyroidism are in good agreement with changes of blood glucose and insulinemia, as described previously. Opposite effect of triamcinolone on FFA and phosphatemia pattern in euthyroidism may suggest the changes of sensitivity of some peripheral tissues to insulin action. The decline of fasting level of FFA after triamcinolone in hyperthyroidism is surprising and might be of importance in maintaining unaltered glucose tolerance after triamcinolone in this subgroup.

Blood Proteins↗
PubMed1976

[Portosystemic anastomosis during pregnancy].

There is discussed the surgical treatment of massive otherwise uncontrolable haemorrhage from oesophageal varices during advanced pregnancy. The authors have performed in the above situation a splenorenal shunt in a women suffering from the prehepatic portal hypertension during her sixth month of pregnancy. The pregnancy was maintained but an unviable child was born. The authors were able to find only 5 quotations from the references available to them dealing with 5 similar cases in women who delivered healthy babies thanks to a surgical intervention (5 times a portal systemic shunt, once a direct operation). The most important prevention of those exceptional surgical indications is the careful evaluation of all circumstances for a pregnancy in women with portal hypertension.

Adult↗
PubMed1975

Serum thyroxine estimation: clinical evaluation of a modified semiautomated method and its ability for differential diagnosis of thyroid diseases.

A modified semiautomated microchemical method for determining serum thyroxine has been described. It consists of the isolation of T4 on a column of cation exchange resin Dowex 50 W X 2 and of a fully automated determination of iodine in the ammoniacal eluate from the column after an acidic mineralization. The diagnostic value of the method has been evaluated on a small group of patients examined for suspected thyroid gland dysfunction, in comparison with a parallel determination of T4 by a CPBA method (Tetrasorb test kit). From the results it follows that the microchemical method gives the results something inferior in comparison with the CPBA technique. The differences of means between the basic diagnostic groups of patients (euthyroids, hypothyroids, and hyperthyroids) in both methods were statistically significant. The extent to which these tests can discriminate was investigated at a 5% discrimination threshold. The discriminatory ability of both methods between hyperthyroidism and euthyroidism is nearly the same. The CPBA method discriminates euthyroids from the hypothyroids better, the results of both tests, however, do not differ too much. It seems to be confirmed that irrespective of the method used, the determination of serum T4 itself can detect neither hyperthyroidism nor hypothyroidism reliably. The possible causes are discussed in this paper.

Autoanalysis↗