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J Havelka

Publications and source records attributed to J Havelka.

At least 37 records · Page 2Linked to original sources
PubMed1991

Application of non-commercial methods for estimation of immunoreactive serum calcitonin in clinical practice (comparison of two methods).

The authors compared the results of two radioimmunological methods for the estimation of immunoreactive calcitonin in human serum. Parallel with the commercial RIA kit the estimation was made by the authors' own modification of this process with their own specific antiserum and radioligand prepared in the laboratory. The results in a large group of patients with medullary carcinoma of the thyroid gland (MCT) in different stages of the disease revealed that although the values obtained by the two methods differ, there is a statistically significant correlation between the values and the clinical evaluation is also comparable.

Calcitonin↗
PubMed1990

[Comparison of 2 methods for determination of antibodies to thyroglobulin in clinical practice].

The authors compared the results of two methods for the estimation of antibodies against thyroglobulin: the principle of the Thymune-T test (Wellcome) is a haemagglutination method; parallel examinations were made by the author's modification of the radiochemical coprecipitation test (RCT). The laboratory results were evaluated in a large clinical group of patients with different types of thyroid disease. It was confirmed that the haemagglutination method gives more frequently positive results than the radiochemical test, in particular in the range of low titres. The chi square test provided, however, evidence that between methods a significant correlation exists. Although the results of the two tests are not necessarily identical in individual patients, it may be stated that RCT is an adequate method of choice, as it is simpler, more rapid and cheaper, and that it can be done in large series with objective automated evaluation of data.

Adult↗
PubMed1985

Incidence of colorectal cancer in proctocolitis: a retrospective study of 959 cases over 40 years.

The incidence of colorectal cancer was studied by the actuarial method in 959 patients with idiopathic proctocolitis seen from 1942 to 1981. Forty five per cent had rectal, 23% left-sided, and 32% total involvement of the colon. Six cancers were found: one in the rectal, one in the left-sided, and four in the total form of the disease. The risk of cancer per patient year in total colitis was zero per 2151 patient years in the first decade, 1/462 in the second decade, 1/315 in the third decade, and 1/75 in the fourth decade. The cumulative risk of developing cancer was zero at 10 years of duration of the disease, approximately 5% at 20 years, 15% at 30 years, and 20% at 35 years. This increase in risk of cancer is less than reported in some other series. Geographical differences in the incidence of cancer in proctocolitis could influence the risk and therefore also the long-term management of patients with proctocolitis in different geographical areas.

Age Factors↗
PubMed1985

Different patterns of blood sugar and serum insulin levels after different glucose preparations.

In a group of 20 in-patients oral glucose tolerance test was performed repeatedly using 100 g of glucose in weak tea and the same amount of glucose in form of commercial flavoured preparation Glukosa Test. Blood sugar (BS) and immunoreactive insulin (IRI) were estimated in venous blood at intervals 0, 30, 60, 90, 120 and 180 mins, respectively. During the test the values of BS alter Glukosa Test were lower at 120 and 180 mins interval than after the pure glucose. The values of IRI after Glukosa Test were higher from 60 to 120 mins interval. Insulinogenic index was therefore significantly higher at 30, 60 and 90 mins interval and in summarized value for the entire test. Our findings of different effects of the same amount of glucose administered in various forms on pattern of blood sugar and insulin cannot been explained from our material. The possibility of different activation of some regulatory mechanism--e.g. so called enteroinsular axis--should be considered.

Antigens↗
PubMed1982

Prizidilol (SK & F 92657), a new vasodilator with beta-blocking properties in the treatment of essential hypertension.

The antihypertensive effect of a new vasodilator with betablocking properties (SK & F 92657) was investigated in 10 patients with mild to moderate essential hypertension. After a mean treatment period of 26,5 weeks (6,5-49 weeks) blood pressure was significantly reduced, from 168 +/- 22/106 +/- 6 mmHg to 144 +/- 19/94 +/- 12 mmHg (p less than 0.05 and 0.025). The mean dose was 410 mg (100-700 mg). Heart rate decreased slightly from 77 +/- 12 to 70 +/- 8 beats/min. Plasma renin activity and plasma aldosterone showed only minor changes. Nausea, heavy dreams, facial and hand flushing and mild depression were reported as side effects. In most patients the symptoms disappeared without reduction in the dose. In one patient anaemia developed after 7 weeks and treatment with prizidilol was stopped. A slight but statistically significant decrease in haemoglobin concentration of 1.1 +/- 0.6 g/dl was observed in 5 of the 10 patients (p less than 0.02). Thus, a mean dose of prizidilol of 410 +/- 242 mg/day had a mean blood pressure lowering effect of 24/12 mmHg. In 7 of the 10 patients (70%) diastolic blood pressure could be reduced to 95 mmHg or less. However, the observed haematological side-effects should be carefully monitored in further studies and may limit the clinical use of prizidilol.

Adrenergic beta-Antagonists↗
PubMed1982

Long-term experience with captopril in severe hypertension.

1 The long-term effect of the converting-enzyme inhibitor captopril was investigated in 76 patients with various forms of severe hypertension, most cases being resistant to a standardised triple therapy (100 mg hydrochlorothiazide or 80-500 mg frusemide; 320 mg propranolol; and 200 mg hydralazine). 2 In each of the three groups examined (essential, renovascular, and renal parenchymatous hypertension) captopril led to a prompt and sustained reduction in systolic and diastolic blood pressure. Up to an observation time of 2 1/2 years patients with renovascular hypertension showed a more pronounced fall in mean diastolic blood pressures than those with essential hypertension. About 90% of all patients required a diuretic and a substantial percentage of patients needed propranolol as a third drug. 3 The most frequent side effects were skin manifestations, taste disturbances, dizziness, and non-productive cough. Serious adverse effects were rare and included one case of leucopenia and one of the nephrotic syndrome, both of them reversed after withdrawal of captopril. Further analysis showed that side effects occurred mainly in patients with impaired kidney function receiving relatively high dosages of captopril (greater than 200 mg/day). 4 Our results show that captopril is a very potent blood-pressure-lowering agent in severe hypertension, especially in cases with renovascular hypertension.

Adult↗
PubMed1981

Comparison of metabolic effects of glucagon and calcitonin and assessment of direct effect of glucagon on calcitonin level in athyroid man.

The effect of intramuscular administration of glucagon (Glg) and calcitonin (Ct) on the pattern of serum calcium (Ca), in organic phosphorus (P), blood glucose (BS), immunoreactive insulin (IRI) and growth hormone (GH) was investigate in 14 patients after total thyroid ablation during replacement therapy. In seven patients the pattern of Ct after Glg administration was assessed in the same conditions. Both hormones induced a prompt and marked decrease of Ca with out any differences between effect of Glg and Ct. The decline of P due to Glg is more rapid and marked than the due to Ct, the difference being significant from 60 to 120 min. Glg caused a rapid and marked rise of BS and IRI with a tendency toward normalization up to 180 min, GH rose significantly from 120 to 180 min. The changes of BS and IRI due to Ct were slow and less marked, but prolonged: level of BS increased and that of IRI decreased. No effect of Ct administration on GH was recorded. In general, neither the effects of Glg nor those of Ct were influenced by hypothyroidism. This fact may be of importance for use of Glg in testing GH reserve in hypothyroidism. Ct after Glg administration in athyroid patients failed to exhibit any significant changes. Thus our results support the assumption about similar and independent action of Glg and Ct on calcium and phosphate homeostasis and different effects of both hormones on glucose metabolism.

Adult↗