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Biomedical subjects

J Hauser

Publications and source records attributed to J Hauser.

101 records · Page 6Linked to original sources
PubMedDate not supplied

[The study of candidate genes in psychiatric disease. II. Affective disorders].

The results of research concerning the importance of genetic factors in etiopathogenesis of affective diseases are presented. In molecular genetics research there are two most frequently applied strategies: searching of the whole genome in order to find new genes and molecular analysis of candidate genes. Candidate gene analysis consist in choosing a gene which could theoretically have a connection with the disease. The polymorphism of a chosen gene is estimated and then its connection with the disease is defined. The presented reference review concerns the results of candidate genes research, which refer to biochemical hypothesis of affective diseases. In many medical centers it was found that in affective disorders the polymorphism of gene's receptor D4, GABA and serotonin transporter could be of etiological importance.

Humans↗
PubMedDate not supplied

[Genetic factors in the etiology of anorexia nervosa].

Anorexia nervosa (AN) is a disease of complex ethiopatogenesis. Population genetics studies suggest a significant role of genetic factors in the morbidity risk. Family and twin studies allow for the estimation of the heritability--the influence of genetic factors on the specific phenotype--of the anorexia nervosa in 50-80%. Due to the low prevalence of the disease, the adoption studies have not been performed. The rapid development of the molecular biology methods gives possibility for the searching of the specific genes increasing the risk of anorexia nervosa. Linkage studies are based on scanning the whole genome for loci associated with susceptibility to a certain disease. In the preliminary studies, no linkage was found between anorexia nervosa and the markers on the chromosomes 1-5, 13 and X. In the association studies, relationship between vulnerability to AN and polymorphism in 5-HT2a receptor and uncoupling proteins gene were reported. These results need further confirmation.

Anorexia Nervosa↗
PubMedDate not supplied

[Usefulness of Widlöcher scale in assessment of psychomotor activity disorders in endogenous depression].

A group of 50 patients with a diagnosis of affective disease was examined. Dependence between the intensification of depression psychomotor activity measured according to Widlöcher scale was established. Neurophysiological factors (such as thinking productivity, letter drafting, tapping test, simple reaction time) correlated with the intensification of psychomotor activation disorders.

Adult↗
PubMedDate not supplied

[Depressive disorders with psychomotor activity in patients with alcohol dependence syndrome].

In a group of 85 men with alcohol dependence syndrome occurrence of depressive symptoms was examined and the intensification of psychomotor activation disorders was assessed. 60% of patients showed symptoms of depression during alcohol intoxication. Relationship between the intensification of depressive symptoms and psychomotor activity disorders was testified.

Adult↗
PubMedDate not supplied

[Analysis of psychological data and social functioning in alcoholics].

74 male alcoholics participated in a three years prospective study. We have analysed data that patients obtained after the detoxification and 1, 2 and 3 years after discharge. Patients were divided into groups according to drinking behaviour. The psychological assessment included the MPI-Eysenck Personality Questionnaire, Q-sort self-esteem scale, Benton test and the WAIS. Social functioning was classified with reference to the Scale of Social Functioning. Our results indicate that the majority of patients presented disturbances in self-esteem and an increased level of neuroticism. These psychological parameters were not connected with a drinking or sober outcome. Our data suggest that the cognitive impairment in alcoholics is relatively constant and does not improve despite sustained abstinence. In the whole group social functioning was disturbed after a period of drinking and was significantly improved together with the duration of abstinence.

Adult↗
PubMedDate not supplied

[Analysis of clinical data on alcoholics: a 3-year follow-up study].

74 male alcoholics participated in a three year prospective study. Data were collected four times: at admission (for the detoxification) and 1, 2 and 3 years after discharge. Patients were divided into groups according to drinking behaviour. Abstainers and relapsers who had been followed up for three years were compared with treatment variables in an attempt to separate those factors which would be predictors of outcome type. Our results indicate that for alcoholics, having an additional diagnosis of antisocial personality or drug dependence was associated with poor outcome. We failed to find a relationship between the history of alcohol dependence (manner of drinking, age of onset etc.) and clinical course. Our results suggest that symptoms of depression and anxiety, observed during a period of detoxification were gradually lowered according to the time of abstinence. Abstinence-status at a 3 year follow-up was associated with regular out-patients treatment especially during the first year after discharge.

Adult↗
PubMedDate not supplied

[The typological analysis of males with alcohol dependence disorder].

The aim of our study was the typological analysis of male alcoholics that was conducted on the basis of the K-means cluster analysis. 296 hospitalized men were examined after a duration of drinking. The results of the statistical analysis let us isolate two and then three types of alcoholics. When dividing the examined into two clusters it appeared that those who belonged to the 1st type had shorter history of addiction, became dependent later and in their case coexistence of psychiatric disorders, somatic diseases and the genetic loading for alcoholism were found less frequently than those from the 2nd type. Thus, early age of dependence onset was connected with the family alcoholism and worse clinical course-i.e.-co-occurrence of psychiatric disorders and somatic diseases. When dividing the patients into three clusters the following variables that differentiate the examined from three types of alcoholics were found: (a)-1st type: late age of dependence onset, rare load of family alcoholism, psychiatric disorders, somatic diseases; (b)-2nd and 3rd type: early age of dependence onset, the load of family-alcoholism, co-occurrence of psychiatric disorders and somatic diseases; (c)-3rd type: patients from the 3rd type were dependent longer than those from the 2nd type. Longer duration of the disease was connected with more frequent occurrence of psychiatric disorders and somatic diseases.

Adult↗
PubMedDate not supplied

[Typological analysis in male alcoholics: one-year-long follow-up study].

The aim of our study was to estimate the correlation between typological division of male alcoholics and intensity of psychopathological symptoms in one year follow-up study. The studies at the Department of Psychiatry in Poznań included 82 men hospitalized after the period of drinking and examined one year after the treatment. The typological division of male alcoholics was the subject of another study and the patients included in this examination belonged to that investigative group. Two typological groups were isolated. The first group included the patients who-were characterized by late age of the disease onset, light load of alcoholic problems in a family, slight intensity of addiction profoundness, rare occurrence of psychiatric disorders and somatic diseases. The second group was characterized by an early age of the disease onset, profound addition, load of alcoholic problems in a family, frequent occurrence of somatic diseases and psychiatric disorders. The psychometric estimation was conducted on the basis of the results of the HDA, STAI XI, X2 scales. It was found out that the attachment to a typological group was not connected with maintaining of abstinence in one-glow follow-up study. In one year follow-up study the patients who belonged to the second typological group were characterized by higher intensity of depressive symptoms.

Adult↗